Matilde Bongianni, PhD; Christina Orrù, PhD; Bradley R. Groveman, PhD; et al.
free access
has audio
JAMA Neurol. 2017;74(2):155-162. doi:10.1001/jamaneurol.2016.4614
This case-control study assesses an algorithm for diagnosis of Creutzfeldt-Jakob disease using cerebrospinal fluid and olfactory mucosa samples among patients with possible, probable, or suspected disease.
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Podcast:
Human Prion Disease Diagnosis Using RT-QuIC Testing (JAMA Neurology)
Mohammad Shahnawaz, PhD; Takahiko Tokuda, MD; Masaaki Waragai, MD; et al.
free access
JAMA Neurol. 2017;74(2):163-172. doi:10.1001/jamaneurol.2016.4547
This study uses cerebrospinal fluid samples from patients with Parkinson disease to develop an assay for diagnosis of Parkinson disease.
Christel Renoux, MD, PhD; Sarah Vahey, MSc; Sophie Dell’Aniello, MSc; et al.
free access
JAMA Neurol. 2017;74(2):173-180. doi:10.1001/jamaneurol.2016.4529
This population-based cohort study assesses the risk for intracranial hemorrhage associated with the use of selective serotonin reuptake inhibitors among new users of antidepressants and according to the strength of inhibition of serotonin reuptake.
Andres Rodriguez Ruiz, MD; Jan Vlachy, MS; Jong Woo Lee, MD, PhD; et al.
free access
JAMA Neurol. 2017;74(2):181-188. doi:10.1001/jamaneurol.2016.4990
This cohort study analyzes the association between periodic and rhythmic pattern frequency and increased risk for seizures in critically ill patients.
Willem-Jan R. Fokkink, MD; Christa Walgaard, MD; Krista Kuitwaard, MD; et al.
free access
JAMA Neurol. 2017;74(2):189-196. doi:10.1001/jamaneurol.2016.4480
This cohort study assesses the association between serum albumin levels and the clinical course and outcome of Guillain-Barré syndrome in patients treated with intravenous immunoglobulin.
Clinical Trial
Andrew J. Lees, MD; Joaquim Ferreira, MD; Olivier Rascol, MD; et al.
free access
JAMA Neurol. 2017;74(2):197-206. doi:10.1001/jamaneurol.2016.4703
This randomized clinical trial assesses the efficacy and safety of opicapone as adjunct to levodopa therapy in patients with Parkinson disease experiencing end-of-dose motor fluctuations.
Brendan P. Lucey, MD; Kwasi G. Mawuenyega, PhD; Bruce W. Patterson, PhD; et al.
free access
JAMA Neurol. 2017;74(2):207-215. doi:10.1001/jamaneurol.2016.4202
This study examines the associations between β-amyloid kinetics, age, amyloid, and the β-amyloid day/night pattern in older adults.
Clinical Trial
Anthony H. V. Schapira, MD, DSc, FRCP, FMedSci; Susan H. Fox, MBChB, MRCP(UK), PhD; Robert A. Hauser, MD, MBA; et al.
free access
JAMA Neurol. 2017;74(2):216-224. doi:10.1001/jamaneurol.2016.4467
This randomized clinical trial investigates the efficacy and safety of safinamide (an oral aminoamide derivative with dopaminergic and nondopaminergic actions) as compared with placebo in levodopa-treated patients with motor fluctuations.
Julie M. Zissimopoulos, PhD; Douglas Barthold, PhD; Roberta Diaz Brinton, PhD; et al.
free access
JAMA Neurol. 2017;74(2):225-232. doi:10.1001/jamaneurol.2016.3783
This study analyzes the association between exposure to statins and Alzheimer disease risk among Medicare beneficiaries.