Marinella Clerico, MD; Irene Schiavetti, BS; Stefania F. De Mercanti, MD; et al.
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JAMA Neurol. 2014;71(8):954-960. doi:10.1001/jamaneurol.2014.1200
Clerico et al evaluate the effect of therapeutic choices on the mean annualized relapse rate and on magnetic resonance imaging multiple sclerosis activity after 24 doses of natalizumab in 124 patients with relapsing-remitting disease. Patients were recruited and stratified into an intent-to-treat group and an as-treated group. See the Editorial by St眉ve and Cutter.
Michael C. Donohue, PhD; Reisa A. Sperling, MD; David P. Salmon, PhD; et al.
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JAMA Neurol. 2014;71(8):961-970. doi:10.1001/jamaneurol.2014.803
Donohue and coauthors demonstrate the feasibility of a cognitive composite outcome for clinically normal elderly participants with evidence of Alzheimer disease pathology using the Alzheimer鈥檚 Disease Cooperative Study Preclinical Alzheimer Cognitive Composite. See the editorial by Kryscio.
Sharon Ooms, MSc; Sebastiaan Overeem, MD; Kees Besse, MD; et al.
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JAMA Neurol. 2014;71(8):971-977. doi:10.1001/jamaneurol.2014.1173
Ooms and colleagues determine the effect of 1 night of total sleep deprivation on cerebrospinal fluid A尾42 protein levels in healthy middle-aged men.
Christian Dehlendorff, MS, PhD; Klaus K. Andersen, MS, PhD; Tom S. Olsen, MD, PhD
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JAMA Neurol. 2014;71(8):978-984. doi:10.1001/jamaneurol.2014.1017
Dehlendorff and colleagues aimed to determine whether the obesity paradox in stroke is real or an artificial finding due to selection bias.
Jay M. Margolis, PharmD; Bong-Chul Chu, PhD; Zhixiao J. Wang, PhD; et al.
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JAMA Neurol. 2014;71(8):985-993. doi:10.1001/jamaneurol.2014.808
Margolis and colleagues compared treatment persistence and health care use with antiepileptic drug combinations categorized by mechanism of action in patients with partial-onset seizures.
Christine L. Mac Donald, PhD; Ann M. Johnson; Linda Wierzechowski, RN; et al.
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JAMA Neurol. 2014;71(8):994-1002. doi:10.1001/jamaneurol.2014.1114
Mac Donald et al determine similarities and differences between clinical outcomes in US military personnel with blast-related vs non鈥揵last-related concussive traumatic brain injury and identify domains of impairment that best correlate with overall disability among personnel enrolled from 2010 to 2013 and evaluated at 6 to 12 months after injury.
Maxwell Greene, MD; Yongjie Lai, MD; Nicolle Baella; et al.
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JAMA Neurol. 2014;71(8):1003-1008. doi:10.1001/jamaneurol.2014.999
Greene et al describe a patient with anti-Tr and confirm that Delta/notch-like epidermal growth factor鈥搑elated receptor (DNER) is the autoantigen in a series of patients with anti-Tr immune response.
Helena Ariño, MD; Nuria Gresa-Arribas, PhD; Yolanda Blanco, MD, PhD; et al.
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JAMA Neurol. 2014;71(8):1009-1016. doi:10.1001/jamaneurol.2014.1011
Ari帽o et al report the symptoms, additional antibodies, prognostic factors, and long-term outcomes in 34 patients with cerebellar ataxia and GAD65-Abs in a retrospective cohort study with laboratory investigations at a center for autoimmune neurologic disorders. Twenty-eight patients with stiff person syndrome and GAD65-Abs served as control subjects.
Prashanthi Vemuri, PhD; Timothy G. Lesnick, MS; Scott A. Przybelski, BS; et al.
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JAMA Neurol. 2014;71(8):1017-1024. doi:10.1001/jamaneurol.2014.963
Vemuri and coauthors investigate the association of lifetime intellectual enrichment with baseline cognitive performance and rate of cognitive decline in an older population without dementia.