ÌÇÐÄvlog

This study using cellular models reports that human neurons derived from human induced pluripotent stem cells provide a signature that will accurately reflect drug response in humans and in cerebrospinal fluid biomarker changes during γ-secretase modulator treatment for Alzheimer disease. Liao and Holtzman provide a related .

This retrospective cohort study found that patients with traumatic brain injury had an increased risk of developing dementia. See also the Editorial by DeKosky.

This case-control study demonstrates that, in Alzheimer disease, increased cerebrospinal fluid orexin levels are related to a parallel sleep deterioration, which appears to be associated with the cognitive decline.

This nested, case-control study reports no longer-term association of vaccines with multiple sclerosis or other acquired central nervous system demyelinating diseases; however, there was a short-term increase in risk.

This genome-wide linkage analysis provides evidence for the presence of potential candidate genes related to exceptional episodic memory in the elderly.

This prospective cohort study identifies [¹⁸F]MNI-659 as a promising striatal imaging biomarker for assessment of early Huntington disease.

This meta-analysis assesses the association between the number of CAG repeat alleles in the ataxin 2 gene (ATXN2) and the risk of amyotrophic lateral sclerosis across multiple ethnic groups.

This quantitative meta-analysis reveals that Parkinson disease pathogenic mutations have an age-dependent penetrance that could be ameliorated or exacerbated by modifier genes or environmental factors in different populations.

This prospective case-controlled study shows that abnormal eating behaviors are prominent in patients with behavioral variant frontotemporal dementia and those with semantic dementia.

This population-based, longitudinal cohort study shows that a high amyloid load does not influence diffusion tensor imaging–based measures of white matter integrity in the absence of coexistent gray matter neurodegeneration in older adults without dementia.