Clinical Trial
The Parkinson Study Group SURE-PD Investigators
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JAMA Neurol. 2014;71(2):141-150. doi:10.1001/jamaneurol.2013.5528
The Parkinson Study Group SURE-PD Investigators determine the safety, tolerability, and urate-elevating capability of the urate precursor inosine in early Parkinson disease and assess its suitability and potential design features for a disease-modification trial.
Fabricio O. Lima, MD, MPH; Karen L. Furie, MD, MPH; Gisele S. Silva, MD, PhD; et al.
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JAMA Neurol. 2014;71(2):151-157. doi:10.1001/jamaneurol.2013.5007
In a prospective cohort study at 2 university-based hospitals between 2003 and 2005, Lima and coauthors investigate the outcomes of patients who had an acute ischemic stroke attributable to an anterior circulation proximal intracranial arterial occlusion. See the editorial by Yahgi and Marshall.
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Podcast:
Prognosis of Untreated Strokes Due to Anterior Circulation Proximal Intracranial Arterial Occlusions Detected by Use of Computed Tomography Angiography, and Proximal Intracranial Arterial Occlusions: Does the Natural History Justify Further Interventional
H. Bart Brouwers, MD; Yuchiao Chang, PhD; Guido J. Falcone, MD, MPH; et al.
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JAMA Neurol. 2014;71(2):158-164. doi:10.1001/jamaneurol.2013.5433
Lauren A. Beslow, MD, MSCE; Rebecca N. Ichord, MD; Melissa C. Gindville, BS, MS; et al.
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JAMA Neurol. 2014;71(2):165-171. doi:10.1001/jamaneurol.2013.4672
Beslow et al assess the frequency and extent of hematoma expansion in children with nontraumatic intracerebral hemorrhage.
Yuichi Riku, MD; Hirohisa Watanabe, MD; Mari Yoshida, MD; et al.
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JAMA Neurol. 2014;71(2):172-179. doi:10.1001/jamaneurol.2013.5489
Riku et al investigated a pathological continuity between FTLD-TDP and ALS by comparing their respective neuropathological changes in the motor neuron system.
Rahul S. Desikan, MD, PhD; Wesley K. Thompson, PhD; Dominic Holland, PhD; et al.
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JAMA Neurol. 2014;71(2):180-187. doi:10.1001/jamaneurol.2013.4560
Desikan and colleagues aimed to elucidate the relationship between clusterin, amyloid-尾, phosphorylated tau, and rate of brain atrophy over time among nondemented older individuals.
Eugene F. Diekman, MD; Tom J. de Koning, PhD, MD; Nanda M. Verhoeven-Duif, PhD; et al.
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JAMA Neurol. 2014;71(2):188-194. doi:10.1001/jamaneurol.2013.4915
Diekman et al investigate the effect of betaine treatment on development and survival in patients with severe methylenetetrahydrofolate reductase (MTHFR) deficiency.
Bruce Reed, PhD; Sylvia Villeneuve, PhD; Wendy Mack, PhD; et al.
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JAMA Neurol. 2014;71(2):195-200. doi:10.1001/jamaneurol.2013.5390
Reed and coauthors investigate the association between serum cholesterol levels and cerebral 尾-amyloid early in the Alzheimer disease process.
Ajay K. Parsaik, MD; Balwinder Singh, MD; Rosebud O. Roberts, MBBCh; et al.
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JAMA Neurol. 2014;71(2):201-207. doi:10.1001/jamaneurol.2013.5402
Parsaik et al evaluate the association of clinical and subclinical hypothyroidism with mild cognitive impairment in a large population-based cohort.
Paola Caroppo, MD, PhD; Isabelle Le Ber, MD, PhD; Fabienne Clot, PhD; et al.
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JAMA Neurol. 2014;71(2):208-215. doi:10.1001/jamaneurol.2013.5100
Caroppo et al analyzed the DCTN1 gene in families with a progressive supranuclear palsy鈥搇ike phenotype at a referral center among 21 patients. In addition, 8 patients and relatives from a family carrying a DCTN1 mutation were evaluated. Outcome measures were identification of the DCTN1 mutation and clinical description of DCTN1 mutation carriers.
Enrico Premi, MD; Anna Formenti, MD; Stefano Gazzina, MD; et al.
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JAMA Neurol. 2014;71(2):216-221. doi:10.1001/jamaneurol.2013.4835
Premi et al ascertain whether TMEM106B genetic status modulates GRN disease by evaluating resting-state functional connectivity in aGRN+ according to TMEM106 genetic variation.