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March 2014, Vol 71, No. 3, Pages 251-375

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2014;71(3):251-253. doi:10.1001/jamaneurol.2013.4136
Viewpoint

Disease Activity Free Status: A New End Point for a New Era in Multiple Sclerosis Clinical Research?

Abstract Full Text
JAMA Neurol. 2014;71(3):269-270. doi:10.1001/jamaneurol.2013.5486
Editorial

Does Aquaporin-4–Seronegative Neuromyelitis Optica Exist?

Abstract Full Text
JAMA Neurol. 2014;71(3):271-272. doi:10.1001/jamaneurol.2013.5865

Environmental Exposures and the Risk for Alzheimer Disease: Can We Identify the Smoking Guns?

Abstract Full Text
JAMA Neurol. 2014;71(3):273-275. doi:10.1001/jamaneurol.2013.6031
Original Investigation

Neuromyelitis Optica Spectrum Disorders With Aquaporin-4 and Myelin-Oligodendrocyte Glycoprotein Antibodies: A Comparative Study

Abstract Full Text
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JAMA Neurol. 2014;71(3):276-283. doi:10.1001/jamaneurol.2013.5857

Kitley and colleagues aimed to characterize the features of patients with neuromyelitis optica (NMO)/NMO spectrum disorder (SD) with myelin-oligodendrocyte glycoprotein antibodies and compare them with patients with aquaporin-4 (AQP4) antibody–positive NMO/NMOSD.

Elevated Serum Pesticide Levels and Risk for Alzheimer Disease

Abstract Full Text
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JAMA Neurol. 2014;71(3):284-290. doi:10.1001/jamaneurol.2013.6030

Richardson and colleagues evaluated the association between serum levels of Dichlorodiphenyldichloroethylene (DDE) and Alzheimer disease (AD) and whether the apolipoprotein genotype modifies the association. DeKosky and Gandy provided a related .

Disparities in Access to Deep Brain Stimulation Surgery for Parkinson Disease: Interaction Between African American Race and Medicaid Use

Abstract Full Text
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JAMA Neurol. 2014;71(3):291-299. doi:10.1001/jamaneurol.2013.5798

Chan et al examine deep brain stimulation use in Parkinson disease to determine which factors, among a variety of demographic, clinical, and socioeconomic variables, drive DBS use in the United States.

Alcohol as a Modifiable Lifestyle Factor Affecting Multiple Sclerosis Risk

Abstract Full Text
free access
JAMA Neurol. 2014;71(3):300-305. doi:10.1001/jamaneurol.2013.5858

Hedström et al investigate the possible influence of alcohol consumption on the risk of developing multiple sclerosis and relate the influence of alcohol to the effect of smoking.

Vitamin D as an Early Predictor of Multiple Sclerosis Activity and Progression

Abstract Full Text
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JAMA Neurol. 2014;71(3):306-314. doi:10.1001/jamaneurol.2013.5993

Ascherio and colleagues aimed to determine whether serum concentrations of 25-hydroxyvitamin D, a marker of vitamin D status, predict disease activity and prognosis in patients with a first event suggestive of multiple sclerosis (clinically isolated syndrome).

Age-Specific Incidence Rates for Dementia and Alzheimer Disease in NIA-LOAD/NCRAD and EFIGA Families: National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) and Estudio Familiar de Influencia Genetica en Alzheimer (EFIGA)

Abstract Full Text
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JAMA Neurol. 2014;71(3):315-323. doi:10.1001/jamaneurol.2013.5570

Vardarajan et al determine the incidence rates of dementia and Alzheimer disease in unaffected family members in the NIA-LOAD/NCRAD and EFIGA family studies.

Comparison of Relapse and Treatment Failure Rates Among Patients With Neuromyelitis Optica: Multicenter Study of Treatment Efficacy

Abstract Full Text
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JAMA Neurol. 2014;71(3):324-330. doi:10.1001/jamaneurol.2013.5699

Mealy and coauthors compare the relapse and treatment failure rates among patients receiving immunosuppression for neuromyelitis optica.

Frontotemporal Dementia Associated With the C9ORF72 Mutation: A Unique Clinical Profile

Abstract Full Text
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JAMA Neurol. 2014;71(3):331-339. doi:10.1001/jamaneurol.2013.6002

Devenney et al aim to determine the frequency of the C9ORF72 mutation in a frontotemporal dementia cohort and to define the clinical, neuropsychological, behavioral, and imaging features of C9ORF72 mutation carriers in comparison with noncarriers in a well-defined behavioral variant–FTD cohort.

Case Report/Case Series

Variant Creutzfeldt-Jakob Disease With Extremely Low Lymphoreticular Deposition of Prion Protein

Abstract Full Text
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JAMA Neurol. 2014;71(3):340-343. doi:10.1001/jamaneurol.2013.5378

Mead and colleagues describe a patient diagnosed as having variant Creutzfeldt-Jakob disease.

Herpes Simplex Encephalitis as a Potential Cause of Anti–N-Methyl-d-Aspartate Receptor Antibody Encephalitis: Report of 2 Cases

Abstract Full Text
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JAMA Neurol. 2014;71(3):344-346. doi:10.1001/jamaneurol.2013.4580

DeSena et al describe 2 patients with herpes simplex (HS) encephalitis in whom testing results also detected anti–N-methyl-d-aspartate (NMDA) receptor antibody encephalitis.

Purkinje Cell Cytoplasmic Antibody Type 1 (Anti-Yo) Autoimmunity in a Child With Down Syndrome

Abstract Full Text
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JAMA Neurol. 2014;71(3):347-349. doi:10.1001/jamaneurol.2013.4551

Philipps et al describe a child with Down syndrome, a history of adrenocortical carcinoma, and cerebellar ataxia of subacute onset. Paraneoplastic serological and cerebrospinal fluid evaluations revealed Purkinje cell cytoplasmic antibody type 1 (PCA-1). Serological and biochemical studies also supported a diagnosis of subclinical autoimmune hypothyroidism.

Review

Pharmacologic Treatment of Downstream of Tyrosine Kinase 7 Congenital Myasthenic Syndrome

Abstract Full Text
JAMA Neurol. 2014;71(3):350-354. doi:10.1001/jamaneurol.2013.5590

Witting and Vissing analyze current information on the effect of pharmacologic treatment of downstream of tyrosine kinase 7 (DOK7) congenital myasthenic syndrome, which is one of the most common subtypes of this syndrome.

Clinical Implications of Basic Neuroscience Research

Newborn Screening for Fragile X Syndrome

Abstract Full Text
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JAMA Neurol. 2014;71(3):355-359. doi:10.1001/jamaneurol.2013.4808

Tassone discusses the inclusion of fragile X syndrome in newborn screening.

Clinical Pathologic Conference

A Rare Adult Cause of Dizziness

Abstract Full Text
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JAMA Neurol. 2014;71(3):360-363. doi:10.1001/jamaneurol.2013.5839

Shu et al report a case of progressively worsening dizziness and ataxia.

Images in Neurology

Ultra Hyperacute Magnetic Resonance Findings in Reperfusion Hemorrhage

Abstract Full Text
JAMA Neurol. 2014;71(3):364-365. doi:10.1001/jamaneurol.2013.131

Relapsing-Remitting Tumefactive Demyelination

Abstract Full Text
JAMA Neurol. 2014;71(3):366-367. doi:10.1001/jamaneurol.2013.5
Comment & Response

Reversible Cerebral Vasoconstriction Syndrome

Abstract Full Text
JAMA Neurol. 2014;71(3):368. doi:10.1001/jamaneurol.2013.5875

Reversible Cerebral Vasoconstriction Syndrome—Reply

Abstract Full Text
JAMA Neurol. 2014;71(3):368-369. doi:10.1001/jamaneurol.2013.5899

Establishing Comparable Requirements and Treatment Groups Before Applying Statistical Comparison

Abstract Full Text
JAMA Neurol. 2014;71(3):369-370. doi:10.1001/jamaneurol.2013.5966

New Oral Anticoagulants and the Risk for Intracranial Hemorrhage

Abstract Full Text
JAMA Neurol. 2014;71(3):370-371. doi:10.1001/jamaneurol.2013.5963

Establishing Comparable Requirements and Treatment Groups Before Applying Statistical Comparison—Reply

Abstract Full Text
JAMA Neurol. 2014;71(3):371-372. doi:10.1001/jamaneurol.2013.6003
Book and Media Review

Review of Emergency Neurology

Abstract Full Text
JAMA Neurol. 2014;71(3):374-375. doi:10.1001/jamaneurol.2013.6045
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2014;71(3):258. doi:10.1001/jamaneurol.2013.4137
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