Less Is More
Daniel J. Morgan, MD, MS; Lisa Pineles, MA; Jill Owczarzak, PhD; et al.
open access
JAMA Intern Med. 2021;181(6):747-755. doi:10.1001/jamainternmed.2021.0269
This survey study of physicians, nurse practitioners, and physician assistants explores practitioner understanding of diagnostic reasoning.
Aditi P. Sen, PhD; So-Yeon Kang, MPH, MBA; Emaan Rashidi, BA; et al.
free access
JAMA Intern Med. 2021;181(6):758-764. doi:10.1001/jamainternmed.2021.0733
This cohort study examines the drugs most commonly covered by out-of-pocket cost offsets such as drug coupons or vouchers, percentage of out-of-pocket costs covered by offsets, and characteristics of patients using offsets for retail pharmacy transactions in the United States in 2017 through 2019.
Robert Goulden, MBBS; Brian H. Rowe, MD; Michal Abrahamowicz, PhD; et al.
free access
JAMA Intern Med. 2021;181(6):767-774. doi:10.1001/jamainternmed.2021.0916
This quasi-experimental cohort study examines the association of intravenous radiocontrast exposure with kidney injury in patients undergoing D-dimer testing.
Rachel K. Nelligan, PGCertPhysio; Rana S. Hinman, PhD; Jessica Kasza, PhD; et al.
free access
JAMA Intern Med. 2021;181(6):776-785. doi:10.1001/jamainternmed.2021.0991
This randomized clinical trial evaluates whether adding a self-directed web-based exercise program and physical activity guide supported by automated behavior-change text messages to an informational osteoarthritis website improves pain and function in people with knee osteoarthritis.
Less Is More
Dong W. Chang, MD, MS; Thanh H. Neville, MD, MSHS; Jennifer Parrish, DO; et al.
free access
has audio
JAMA Intern Med. 2021;181(6):786-794. doi:10.1001/jamainternmed.2021.1000
This quality improvement study uses data from medical intensive care units to investigate the association between time-limited trials and nonbeneficial treatments.
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Podcast:
Time-Limited Trials Among Patients With Advanced Illness to Reduce Nonbeneficial ICU Treatments
Anh Hoang, BS; Kathleen Fagan, MD, MPH; Dawn L. Cannon, MD, MS; et al.
open access
JAMA Intern Med. 2021;181(6):797-805. doi:10.1001/jamainternmed.2021.1063
This case series analyzes characteristics of methylene chloride鈥搑elated fatalities in the United States from 1980 to 2018.
Phuong T. Tran, MPH; Patrick J. Antonelli, MD; Juan M. Hincapie-Castillo, PharmD, PhD; et al.
free access
JAMA Intern Med. 2021;181(6):808-816. doi:10.1001/jamainternmed.2021.1154
This interupted time series study analyzes the association of the implementation of oral quinolone safety warnings and indication restrictions with trends in prescriptoin practices and usage among patients with uncomplicated urinary tract infection, acute sinusitis, and acute exacerbation of chronic obstructive pulmonary disease.
Jordan K. Schaefer, MD; Josh Errickson, PhD; Yun Li, PhD; et al.
free access
JAMA Intern Med. 2021;181(6):817-824. doi:10.1001/jamainternmed.2021.1197
This cohort study evaluates whether dual therapy with acetylsalicylic acid and a therapeutically dosed direct oral anticoagulant increases rates of bleeding.
Less Is More
Judith J. de Jong, MD; Marten A. Lantinga, MD, PhD; Adriaan C. I. T. L. Tan, MD, PhD; et al.
free access
JAMA Intern Med. 2021;181(6):825-833. doi:10.1001/jamainternmed.2021.1408
This open-label, multicenter, randomized clinical trial assesses whether providing relevant patient-managed web-based education in addition to usual care decreases the need for upper gastrointestinal tract endoscopic procedures vs usual care alone in patients with uninvestigated dyspepsia referred for endoscopy.
Health Care Policy and Law
Aditi P. Sen, PhD; Mark K. Meiselbach, BS; Yang Wang, BS; et al.
free access
JAMA Intern Med. 2021;181(6):834-841. doi:10.1001/jamainternmed.2021.1422
This cohort study uses national commercial claims data to evaluate the frequency and cost of out-of-network bills for outpatient laboratory services compared with in-network laboratory services.