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November 2021, Vol 181, No. 11, Pages 1429-1544

Original Investigation

Association of Social Isolation With Disability Burden and 1-Year Mortality Among Older Adults With Critical Illness

Abstract Full Text
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JAMA Intern Med. 2021;181(11):1433-1439. doi:10.1001/jamainternmed.2021.5022

This cohort study of participants in the National Health and Aging Trends Study examines the association of social isolation with disability burden and mortality for older adults with critical illness.

Association of Thyroid Dysfunction With Cognitive Function: An Individual Participant Data Analysis

Abstract Full Text
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JAMA Intern Med. 2021;181(11):1440-1450. doi:10.1001/jamainternmed.2021.5078

This individual participant data analysis assesses the cross-sectional and longitudinal associations of baseline thyroid dysfunction with cognitive function and dementia.

Effect of an Oncology Nurse–Led Primary Palliative Care Intervention on Patients With Advanced Cancer: The CONNECT Cluster Randomized Clinical Trial

Abstract Full Text
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JAMA Intern Med. 2021;181(11):1451-1460. doi:10.1001/jamainternmed.2021.5185

This cluster randomized clinical trial evaluates the quality of life, symptom burden, and anxiety and depression reported by adults with advanced cancer who were receiving a primary palliative care intervention.

Physician Work Environment and Well-Being

Association Between Physician Part-time Clinical Work and Patient Outcomes

Abstract Full Text
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JAMA Intern Med. 2021;181(11):1461-1469. doi:10.1001/jamainternmed.2021.5247

This cross-sectional study examines the association between the number of days worked clinically per year by physicians and patient mortality.

Comparison of Routine Replacement With Clinically Indicated Replacement of Peripheral Intravenous Catheters

Abstract Full Text
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JAMA Intern Med. 2021;181(11):1471-1478. doi:10.1001/jamainternmed.2021.5345

This cohort study examines the association between the incidence of peripheral intravenous catheter bloodstream infections and a change in hospital policy from routine catheter replacement to clinically indicated catheter replacement.

Effectiveness and Ethics of Incentives for Research Participation: 2 Randomized Clinical Trials

Abstract Full Text
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JAMA Intern Med. 2021;181(11):1479-1488. doi:10.1001/jamainternmed.2021.5450

This trial examines whether incentives improve enrollment in real randomized clinical trials or serve as undue or unjust inducements.

Less Is More

Low-Value Care at the Actionable Level of Individual Health Systems

Abstract Full Text
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JAMA Intern Med. 2021;181(11):1490-1500. doi:10.1001/jamainternmed.2021.5531

This cohort study uses Medicare data to measure and report low-value care use across and within individual health systems and identify system characteristics associated with higher use.

Editorial

Less Is More

Moving Beyond Guidelines—Use of Value-Based Preoperative Testing

Abstract Full Text
JAMA Intern Med. 2021;181(11):1431-1432. doi:10.1001/jamainternmed.2021.4081
Invited Commentary

Outcomes of Care by Hospitalists: Do Their Schedules Matter?

Abstract Full Text
JAMA Intern Med. 2021;181(11):1469-1470. doi:10.1001/jamainternmed.2021.5246

Evidence for the Ethics of Incentivizing Clinical Trial Enrollment?

Abstract Full Text
JAMA Intern Med. 2021;181(11):1488-1489. doi:10.1001/jamainternmed.2021.5449
Teachable Moment

Less Is More

Seronegative Chronic Hepatitis C Virus Infection: A Teachable Moment

Abstract Full Text
JAMA Intern Med. 2021;181(11):1501-1502. doi:10.1001/jamainternmed.2021.5182

This Teachable Moment discusses the prevalence of and recommended diagnostic testing for seronegative chronic hepatitis C virus infections.

Research Letter

Communication of Survival Data in US Food and Drug Administration–Approved Labeling of Cancer Drugs

Abstract Full Text
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JAMA Intern Med. 2021;181(11):1521-1522. doi:10.1001/jamainternmed.2021.3505

This cross-sectional study examines how information on overall survival benefits of novel cancer drug indications is communicated in labeling.

Public-sector Contributions to Novel Biologic Drugs

Abstract Full Text
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JAMA Intern Med. 2021;181(11):1522-1525. doi:10.1001/jamainternmed.2021.3720

This cohort study investigates downstream public-sector support for the creation of new biologic drugs by examining their patent and drug development histories.

Health Care Policy and Law

Racial and Ethnic Disparities in Outpatient Visit Rates Across 29 Specialties

Abstract Full Text
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JAMA Intern Med. 2021;181(11):1525-1527. doi:10.1001/jamainternmed.2021.3771

This cross-sectional study examines US racial/ethnic disparities in outpatient visit rates to 29 physician specialties.

Less Is More

Use of High-risk Medications Among Lonely Older Adults: Results From a Nationally Representative Sample

Abstract Full Text
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JAMA Intern Med. 2021;181(11):1528-1530. doi:10.1001/jamainternmed.2021.3775

This cross-sectional study investigates the relationship between loneliness and high-risk medication use in adults older than 65 years.

Safety Evaluation of the Second Dose of Messenger RNA COVID-19 Vaccines in Patients With Immediate Reactions to the First Dose

Abstract Full Text
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JAMA Intern Med. 2021;181(11):1530-1533. doi:10.1001/jamainternmed.2021.3779

This case series study examines the safety of second doses of messenger RNA COVID-19 vaccines after first-dose allergic reactions.

Less Is More

Prevalence, Costs, and Consequences of Low-Value Preprocedural Urinalyses in the US

Abstract Full Text
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JAMA Intern Med. 2021;181(11):1533-1535. doi:10.1001/jamainternmed.2021.4075

This cohort study analyzes inpatient and outpatient episodes of procedural and surgical care to assess the prevalence and costs of low-value preprocedural urinalyses in the US from 2007 to 2017.

Ongoing Citations of a Retracted Study Involving Cardiovascular Disease, Drug Therapy, and Mortality in COVID-19

Abstract Full Text
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JAMA Intern Med. 2021;181(11):1535-1537. doi:10.1001/jamainternmed.2021.4112

This quality improvement study examines the continued citations of a widely publicized retracted article on COVID-19.

Age at Diagnosis of Diabetes by Race and Ethnicity in the United States From 2011 to 2018

Abstract Full Text
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JAMA Intern Med. 2021;181(11):1537-1539. doi:10.1001/jamainternmed.2021.4945

This cross-sectional study uses data from the National Health and Nutrition Examination Survey to assess age at diagnosis of diabetes by race/ethnicity in the US from 2011 to 2018.

Challenges in Clinical Electrocardiography

Typical Electrocardiogram Pattern Unmasks Atypical Cause of Muscle Weakness

Abstract Full Text
JAMA Intern Med. 2021;181(11):1503-1504. doi:10.1001/jamainternmed.2021.3198

This case report describes the electrocardiographic results of a woman admitted to the emergency department for severe weakness of the lower extremities.

Syncope in a Middle-aged Man: A Revealing Electrocardiogram

Abstract Full Text
JAMA Intern Med. 2021;181(11):1505-1506. doi:10.1001/jamainternmed.2021.4027

This case report discusses the electrocardiographic findings of a man in his 40s with hypertension who presented to the emergency department after becoming unresponsive during descent on a commercial flight.

Do Not Dismiss That Wenckebach

Abstract Full Text
JAMA Intern Med. 2021;181(11):1507-1508. doi:10.1001/jamainternmed.2021.4031

This case report presents electrocardiographic findings in a patient in their mid-70s with recurrent syncopal attacks and a history of hypertension.

ST-Segment Elevation Myocardial Infarction Mimic: Unearthing the Hidden Truth

Abstract Full Text
JAMA Intern Med. 2021;181(11):1509-1510. doi:10.1001/jamainternmed.2021.4427

This case report presents the electrocardiographic findings in a woman in her 60s with hypertension who presented to the emergency department with sudden-onset chest pain and tachycardia.

A Young Man With Wide Complex Tachycardia—The Devil Is in the Details

Abstract Full Text
JAMA Intern Med. 2021;181(11):1511-1513. doi:10.1001/jamainternmed.2021.5385

This case report describes a man in his 20s who presented to the emergency department with intermittent palpitations for 2 days and no history of chest pain, dyspnea, congestion, or fever. What is your diagnosis?

Persistent ST-Segment Elevation in a Young Man

Abstract Full Text
JAMA Intern Med. 2021;181(11):1514-1515. doi:10.1001/jamainternmed.2021.4432

This case report considers echocardiogram findings in young man with no history of cardiovascular disease who presented with exertional chest distress.

Toxic Effects of Flecainide in a Patient With Kidney Failure and Tachyarrhythmia

Abstract Full Text
JAMA Intern Med. 2021;181(11):1516-1518. doi:10.1001/jamainternmed.2021.5030

This case report presents electrocardiographic findings in a woman with a history of kidney and ureteral stones and persistent atrial fibrillation who presented with light-headedness.

ST-Segment Elevation in a Man Receiving Peritoneal Dialysis

Abstract Full Text
JAMA Intern Med. 2021;181(11):1519-1520. doi:10.1001/jamainternmed.2021.5389

This case report examines echocardiogram findings in a man with a history of chronic kidney disease, peritoneal dialysis, and myocardial infarction who presented with heart palpitations and severe weakness of the upper and lower extremities.

Comment & Response

Preventing Media-Based False Hopes: A Shared Responsibility

Abstract Full Text
JAMA Intern Med. 2021;181(11):1539. doi:10.1001/jamainternmed.2021.4453

Preventing Media-Based False Hopes‸é±ð±è±ô²â

Abstract Full Text
JAMA Intern Med. 2021;181(11):1539-1540. doi:10.1001/jamainternmed.2021.4450

To Deprescribe or Not to Deprescribe Aspirin—A Clear Indication Is the Challenge

Abstract Full Text
JAMA Intern Med. 2021;181(11):1540-1541. doi:10.1001/jamainternmed.2021.4590

To Deprescribe or Not to Deprescribe Aspirin—A Clear Indication Is the Challenge‸é±ð±è±ô²â

Abstract Full Text
JAMA Intern Med. 2021;181(11):1541. doi:10.1001/jamainternmed.2021.4593

A Tale of 2 Epidemics

Abstract Full Text
JAMA Intern Med. 2021;181(11):1542. doi:10.1001/jamainternmed.2021.4272

A Tale of 2 Epidemics‸é±ð±è±ô²â

Abstract Full Text
JAMA Intern Med. 2021;181(11):1542. doi:10.1001/jamainternmed.2021.4275

Use and Misuse of Quality Indicators to Characterize Screening as Excessive

Abstract Full Text
JAMA Intern Med. 2021;181(11):1542-1543. doi:10.1001/jamainternmed.2021.5368

Use and Misuse of Quality Indicators to Characterize Screening as Excessive‸é±ð±è±ô²â

Abstract Full Text
JAMA Intern Med. 2021;181(11):1543-1544. doi:10.1001/jamainternmed.2021.5354
Correction

Errors in Figure 2 and eTable 3 in the Supplement

Abstract Full Text
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JAMA Intern Med. 2021;181(11):1544. doi:10.1001/jamainternmed.2021.5417

Error in Author Affiliation

Abstract Full Text
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JAMA Intern Med. 2021;181(11):1544. doi:10.1001/jamainternmed.2021.6493

Error in Figure

Abstract Full Text
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JAMA Intern Med. 2021;181(11):1544. doi:10.1001/jamainternmed.2021.6495
JAMA Internal Medicine Masthead

JAMA Internal Medicine

Abstract Full Text
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JAMA Intern Med. 2021;181(11):1429. doi:10.1001/jamainternmed.2020.5303
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