Chana A. Sacks, MD, MPH; Victor L. Van de Wiele, LLB, LLM; Lisa A. Fulchino, MPH; et al.
free access
JAMA Intern Med. 2021;181(1):16-22. doi:10.1001/jamainternmed.2020.3588
This cohort study examines the varying policies on substitution of generic drugs for brand-name products throughout the US.
Carlo Salvarani, MD; Giovanni Dolci, MD; Marco Massari, MD; et al.
free access
JAMA Intern Med. 2021;181(1):24-31. doi:10.1001/jamainternmed.2020.6615
This randomized clinical trial evaluates the effect of early tocilizumab administration vs standard therapy in preventing clinical worsening in patients hospitalized with COVID-19.
Olivier Hermine, MD, PhD; Xavier Mariette, MD, PhD; Pierre-Louis Tharaux, MD, PhD; et al.
free access
JAMA Intern Med. 2021;181(1):32-40. doi:10.1001/jamainternmed.2020.6820
This randomized clinical trial examines the effects of tocilizumab vs usual care in patients hospitalized with COVID-19 and moderate-to-severe pneumonia.
Shruti Gupta, MD, MPH; Wei Wang, PhD; Salim S. Hayek, MD; et al.
free access
JAMA Intern Med. 2021;181(1):41-51. doi:10.1001/jamainternmed.2020.6252
This cohort study assesses mortality rates among patients with COVID-19 admitted to intensive care who were treated with tocilizumab.
Thomas J. Moore, AB; Morgane C. Mouslim, DVM; Jenna L. Blunt, PharmD; et al.
free access
JAMA Intern Med. 2021;181(1):52-60. doi:10.1001/jamainternmed.2020.3997
This study examines the US Food and Drug Administration鈥檚 approval process for biosimilar biologic products by evaluating the site and facility inspections, animal and human studies, and comparative efficacy trials conducted to support the applications.
Bradley P. Turnwald, PhD; Isaac J. Handley-Miner, BA; Natalie A. Samuels, BA; et al.
free access
JAMA Intern Med. 2021;181(1):61-70. doi:10.1001/jamainternmed.2020.5421
This qualitative study compares nutritional content depicted in the 250 top-grossing US movies from 1994 to 2018 with established nutrition rating systems, dietary recommendations, and US individuals鈥� actual consumption.
Lin-ling Cheng, MD; Wei-jie Guan, PhD; Chong-yang Duan, PhD; et al.
free access
JAMA Intern Med. 2021;181(1):71-78. doi:10.1001/jamainternmed.2020.5503
This randomized clinical trial examines the effect of recombinant human granulocyte colony-stimulating factor on peripheral blood leukocyte and lymphocyte cell counts and clinical improvement in Chinese patients with COVID-19.
Seon Ha Baek, PhD; You Hwan Jo, PhD; Soyeon Ahn, PhD; et al.
free access
JAMA Intern Med. 2021;181(1):81-92. doi:10.1001/jamainternmed.2020.5519
This randomized clinical trial compares the risk of overcorrection with use of rapid intermittent bolus and slow continuous infusion with hypertonic saline in patients with symptomatic severe hyponatremia.
Donald R. Sullivan, MD, MA, MCR; Hyosin Kim, PhD; Pedro L. Gozalo, PhD; et al.
free access
has audio
JAMA Intern Med. 2021;181(1):93-102. doi:10.1001/jamainternmed.2020.5640
This cohort study describes the ventilatory support provided within 30 days of death in older adults with chronic obstructive pulmonary disease, congestive heart failure, cancer, or dementia.
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Podcast:
Trends in Noninvasive and Invasive Mechanical Ventilation Among Medicare Beneficiaries at the End of Life
Rodrigo Oliveira Mascarenhas, MSc; Mateus Bastos Souza, BAppSc; Murilo Xavier Oliveira, PhD; et al.
free access
JAMA Intern Med. 2021;181(1):104-112. doi:10.1001/jamainternmed.2020.5651
This systematic review and meta-analysis investigates the effectiveness of therapies for reducing pain and improving quality of life in people with fibromyalgia.