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October 2024 - January 1908

Decade

Year

Issue

October 2021, Vol 181, No. 10, Pages 1274-1421

Viewpoint

Fulfilling the Mandate of the US Food and Drug Administration鈥檚 Accelerated Approval Pathway: The Need for Reforms

Abstract Full Text
JAMA Intern Med. 2021;181(10):1275-1276. doi:10.1001/jamainternmed.2021.4604

This Viewpoint discusses the US Food and Drug Administration鈥檚 accelerated approval pathway and proposes the need for reforms as well as the timely completion of postapproval trials.

Approval of Aducanumab for Alzheimer Disease鈥擳he FDA鈥檚 Perspective

Abstract Full Text
JAMA Intern Med. 2021;181(10):1276-1278. doi:10.1001/jamainternmed.2021.4607

This Viewpoint discusses the rationale and data supporting the FDA鈥檚 accelerated approval of aducanumab for Alzheimer disease treatment.

Medicare and the Shocking US Food and Drug Administration Approval of Aducanumab: Crisis or Opportunity?

Abstract Full Text
JAMA Intern Med. 2021;181(10):1278-1280. doi:10.1001/jamainternmed.2021.4610

This Viewpoint discusses the US Food and Drug Administration鈥檚 approval of aducanumab for the treatment of Alzheimer disease and considers the implications of the decision for the Medicare program.

Perspective

Reassessing the Role of Routine Urine Drug Screening in Opioid Use Disorder Treatment

Abstract Full Text
JAMA Intern Med. 2021;181(10):1282-1283. doi:10.1001/jamainternmed.2021.4109

This essay considers how routine drug screening for opioids can threaten the trust between patient and physician, transforming a partnership aimed at improving health into a dynamic of judge and accused.

Original Investigation

Effectiveness of App-Delivered, Tailored Self-management Support for Adults With Lower Back Pain鈥揜elated Disability: A selfBACK Randomized Clinical Trial

Abstract Full Text
open access
JAMA Intern Med. 2021;181(10):1288-1296. doi:10.1001/jamainternmed.2021.4097

This randomized clinical trial examines a decision support tool that provides lower back pain information and self-management recommendations that are specific to an individual鈥檚 characteristics, symptoms, and symptom progression.

Association Between Neighborhood Disadvantage and Functional Well-being in Community-Living Older Persons

Abstract Full Text
free access
JAMA Intern Med. 2021;181(10):1297-1304. doi:10.1001/jamainternmed.2021.4260

This cohort study evaluates whether estimates of active and disabled life expectancy differ on the basis of neighborhood disadvantage after accounting for individual-level socioeconomic characteristics and other prognostic factors.

Association of BNT162b2 mRNA and mRNA-1273 Vaccines With COVID-19 Infection and Hospitalization Among Patients With Cirrhosis

Abstract Full Text
free access
JAMA Intern Med. 2021;181(10):1306-1314. doi:10.1001/jamainternmed.2021.4325

This cohort study examines the association of receipt of the Pfizer BNT162b2 mRNA or the Moderna mRNA-1273 vaccines in patients with cirrhosis compared with a propensity-matched control group of patients at similar risk of infection and severe disease from COVID-19.

Association Between Prison Crowding and COVID-19 Incidence Rates in Massachusetts Prisons, April 2020-January 2021

Abstract Full Text
free access
JAMA Intern Med. 2021;181(10):1315-1321. doi:10.1001/jamainternmed.2021.4392

This longitudinal ecological study estimates the associations between prison crowding, community COVID-19 transmission, and prison incidence rates of COVID-19.

Health Care Policy and Law

Association of Surprise-Billing Legislation with Prices Paid to In-Network and Out-of-Network Anesthesiologists in California, Florida, and New York: An Economic Analysis

Abstract Full Text
free access
JAMA Intern Med. 2021;181(10):1324-1331. doi:10.1001/jamainternmed.2021.4564

This economic analysis examines more than 2.5 million insurance claims for anesthesia services paid to in- and out-of-network practitioners before and after surprise-billing legislation was passed in California, Florida, and New York.

Association Between Prenatal Exposure to Antipsychotics and Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Preterm Birth, and Small for Gestational Age

Abstract Full Text
open access has audio
JAMA Intern Med. 2021;181(10):1332-1340. doi:10.1001/jamainternmed.2021.4571

This cohort study examines the association between prenatal antipsychotics exposure and the risk of birth and neurodevelopmental problems.

COVID-19 Transmission Dynamics Among Close Contacts of Index Patients With COVID-19: A Population-Based Cohort Study in Zhejiang Province, China

Abstract Full Text
free access
JAMA Intern Med. 2021;181(10):1343-1350. doi:10.1001/jamainternmed.2021.4686

This cohort study evaluates the association between the timing of exposure to and severity of COVID-19 disease in close contacts of index patients with COVID-19.

Less Is More

Evaluation of Gender Inequity in Thyroid Cancer Diagnosis: Differences by Sex in US Thyroid Cancer Incidence Compared With a Meta-analysis of Subclinical Thyroid Cancer Rates at Autopsy

Abstract Full Text
open access
JAMA Intern Med. 2021;181(10):1351-1358. doi:10.1001/jamainternmed.2021.4804

This cohort study and meta-analysis examines differences by sex in US thyroid cancer incidence ratios compared with subclinical thyroid cancer rates at autopsy to understand more about gender inequities in thyroid cancer diagnosis.

Less Is More

Accounting for Age in the Definition of Chronic Kidney Disease

Abstract Full Text
free access
JAMA Intern Med. 2021;181(10):1359-1366. doi:10.1001/jamainternmed.2021.4813

This cohort study examines outcomes associated with chronic kidney disease as defined by a fixed vs an age-adapted estimated glomerular filtration rate threshold.

Efficacy of Blended Collaborative Care for Patients With Heart Failure and Comorbid Depression: A Randomized Clinical Trial

Abstract Full Text
open access
JAMA Intern Med. 2021;181(10):1369-1380. doi:10.1001/jamainternmed.2021.4978

This randomized clinical trial assesses whether a blended collaborative care program for treating both heart failure and depression can improve clinical outcomes more than collaborative care for heart failure only and physicians鈥 usual care.

Editorial

Updated USPSTF Screening Recommendations for Diabetes: Identification of Abnormal Glucose Metabolism in Younger Adults

Abstract Full Text
has audio
JAMA Intern Med. 2021;181(10):1284-1286. doi:10.1001/jamainternmed.2021.4886

Overuse of Levothyroxine in Patients With Subclinical Hypothyroidism: Time to 鈥淟eve鈥-Out-Thyroxine

Abstract Full Text
JAMA Intern Med. 2021;181(10):1286-1287. doi:10.1001/jamainternmed.2021.2690
Invited Commentary

The Fundamental Unfairness of Active Life Span Disparity

Abstract Full Text
JAMA Intern Med. 2021;181(10):1304-1305. doi:10.1001/jamainternmed.2021.4269

Avoiding COVID-19 Outbreaks in Carceral Settings

Abstract Full Text
free access
JAMA Intern Med. 2021;181(10):1322-1323. doi:10.1001/jamainternmed.2021.4389

Continuation of Antipsychotic Treatment in Pregnancy鈥擠o Not Panic

Abstract Full Text
has audio
JAMA Intern Med. 2021;181(10):1341-1342. doi:10.1001/jamainternmed.2021.4562

Less Is More

Overdiagnosis of Chronic Kidney Disease in Older Adults鈥擜n Inconvenient Truth

Abstract Full Text
JAMA Intern Med. 2021;181(10):1366-1368. doi:10.1001/jamainternmed.2021.4823

Moving Toward Fully Blended Collaborative Care: Integrating Medical and Social Care

Abstract Full Text
JAMA Intern Med. 2021;181(10):1380-1382. doi:10.1001/jamainternmed.2021.4993

Underuse of Electronic Health Record Features鈥擳he Case for CancelRx

Abstract Full Text
JAMA Intern Med. 2021;181(10):1384-1385. doi:10.1001/jamainternmed.2021.4878
Editor's Note

The Accelerated Approval of Aducanumab for Treatment of Patients With Alzheimer Disease

Abstract Full Text
JAMA Intern Med. 2021;181(10):1281. doi:10.1001/jamainternmed.2021.4622

Protection Because of Prior SARS-CoV-2 Infection

Abstract Full Text
free access
JAMA Intern Med. 2021;181(10):1409. doi:10.1001/jamainternmed.2021.2966
Teachable Moment

Electronic Health Record Interoperability鈥擶hy Electronically Discontinued Medications Are Still Dispensed

Abstract Full Text
JAMA Intern Med. 2021;181(10):1383-1384. doi:10.1001/jamainternmed.2021.4881

This Teachable Moment examines electronic prescription programs used within electronic health records and pharmacy systems.

Research Letter

Early Hospital Compliance With Federal Requirements for Price Transparency

Abstract Full Text
free access
JAMA Intern Med. 2021;181(10):1396-1397. doi:10.1001/jamainternmed.2021.2531

This cross-sectional study assesses compliance within a random sample of hospitals with a federal rule requiring hospitals to disclose the prices they negotiate with insurers.

American Board of Medical Specialties Board Examination Lactation Accommodation Policies

Abstract Full Text
free access
JAMA Intern Med. 2021;181(10):1397-1399. doi:10.1001/jamainternmed.2021.2536

This cross-sectional study evaluated American Board of Medical Specialties member boards鈥 lactation-specific board examination accommodation policies and corroborated the outcomes of these policies by comparing the self-reported experiences of lactating or potentially lactating female physicians with board examinations.

Association of Changes in Seasonal Respiratory Virus Activity and Ambulatory Antibiotic Prescriptions With the COVID-19 Pandemic

Abstract Full Text
free access
JAMA Intern Med. 2021;181(10):1399-1402. doi:10.1001/jamainternmed.2021.2621

This pre-post study examines the association between respiratory virus incidence and ambulatory antibiotic orders and the COVID-19 pandemic.

Levothyroxine Use in the United States, 2008-2018

Abstract Full Text
free access
JAMA Intern Med. 2021;181(10):1402-1405. doi:10.1001/jamainternmed.2021.2686

This cross-sectional study assesses national data for commercially insured and Medicare Advantage enrollees to analyze the use of levothyroxine in the US over time.

Changes Associated With the Entry of a Biosimilar in the Insulin Glargine Market

Abstract Full Text
free access
JAMA Intern Med. 2021;181(10):1405-1407. doi:10.1001/jamainternmed.2021.2769

This study explores the shifts in total US sales and net prices for all 3 insulin glargine products from quarter 1 of 2010 through quarter 2 of 2020.

Assessment of SARS-CoV-2 Reinfection 1 Year After Primary Infection in a Population in Lombardy, Italy

Abstract Full Text
open access
JAMA Intern Med. 2021;181(10):1407-1408. doi:10.1001/jamainternmed.2021.2959

This cohort study examines the rate of SARS-CoV-2 reinfection among people in Lombardy, Italy, who previously recovered from COVID-19.

Assessment of FDA Approval for New High-risk Therapeutic Devices Not Meeting Pivotal Study Primary End Points, 2016-2020

Abstract Full Text
free access
JAMA Intern Med. 2021;181(10):1409-1412. doi:10.1001/jamainternmed.2021.3042

This cross-sectional study explores the frequency of, and rationale for, US Food and Drug Administration approval of high-risk therapeutic medical devices not meeting pivotal study primary end points from 2016 through 2020.

Diabetes Care and Glycemic Control During the COVID-19 Pandemic in the United States

Abstract Full Text
free access
JAMA Intern Med. 2021;181(10):1412-1414. doi:10.1001/jamainternmed.2021.3047

This cohort study compares rates at which patients with type 2 diabetes received diabetes-related health services prior to and during the COVID-19 pandemic.

Comparison of Spending on Common Generic Drugs by Medicare vs Costco Members

Abstract Full Text
free access
JAMA Intern Med. 2021;181(10):1414-1416. doi:10.1001/jamainternmed.2021.3366

This cross-sectional study uses 2017 and 2018 Medicare Part D clams to compare the amount Medicare pays for common generic prescriptions in Part D with prices available to patients without insurance at Costco.

Challenges in Clinical Electrocardiography

Sustained Wide Complex Tachycardia in a Healthy Man

Abstract Full Text
JAMA Intern Med. 2021;181(10):1386-1387. doi:10.1001/jamainternmed.2021.3512

This case report describes the electrocardiographic findings of a man in his 40s with palpitations lasting more than 30 hours, no prior symptoms, and a wide complex tachycardia with a rate of 180 beats/min.

A Common Electrocardiogram Demonstrating an Uncommon Cause

Abstract Full Text
JAMA Intern Med. 2021;181(10):1388-1390. doi:10.1001/jamainternmed.2021.3516

This case report describes the electrocardiographic findings of a man in his 60s with a history of hypertension who presented to the emergency department with acute chest pain.

A Rare Sequence of Events in Acute Coronary Syndrome

Abstract Full Text
JAMA Intern Med. 2021;181(10):1391-1392. doi:10.1001/jamainternmed.2021.4016

This case report presents the electrocardiographic findings of a patient in their 50s with intermittent rest angina, followed by continuous chest pain at rest.

Massive Discordant T-Wave Alternans and Imminent Torsades de Pointes: The 鈥淓lephant in the Room鈥

Abstract Full Text
JAMA Intern Med. 2021;181(10):1393-1395. doi:10.1001/jamainternmed.2021.4021

This case report presents the electrocardiographic findings of a woman in her 50s with a history of long QT syndrome who presented to the emergency department with chest pain and presyncopal episodes.

Comment & Response

Uncertainty in Medicine

Abstract Full Text
JAMA Intern Med. 2021;181(10):1416-1417. doi:10.1001/jamainternmed.2021.3705

Uncertainty in Medicine

Abstract Full Text
JAMA Intern Med. 2021;181(10):1417-1418. doi:10.1001/jamainternmed.2021.3708

Uncertainty in Medicine鈥擱eply

Abstract Full Text
JAMA Intern Med. 2021;181(10):1418. doi:10.1001/jamainternmed.2021.3711

Timely Family Meetings or Time-Limited Trials?

Abstract Full Text
JAMA Intern Med. 2021;181(10):1418-1419. doi:10.1001/jamainternmed.2021.3714

Timely Family Meetings or Time-Limited Trials?鈥擱eply

Abstract Full Text
JAMA Intern Med. 2021;181(10):1419. doi:10.1001/jamainternmed.2021.3717

Caution in Interpreting Facial Paralysis Data to Understand COVID-19 Vaccination Risks

Abstract Full Text
free access
JAMA Intern Med. 2021;181(10):1420. doi:10.1001/jamainternmed.2021.4333

Caution in Interpreting Facial Paralysis Data to Understand COVID-19 Vaccination Risks鈥擱eply

Abstract Full Text
free access
JAMA Intern Med. 2021;181(10):1420-1421. doi:10.1001/jamainternmed.2021.4336

Discrepancy in the Number of Patients in the Analyses in Study of Development and Validation of the Good Outcome Following Attempted Resuscitation Score

Abstract Full Text
JAMA Intern Med. 2021;181(10):1421. doi:10.1001/jamainternmed.2020.6664
Correction

Error Due to Inclusion of Patients With Incomplete Data in an Analysis

Abstract Full Text
free access
JAMA Intern Med. 2021;181(10):1421. doi:10.1001/jamainternmed.2021.4695
JAMA Internal Medicine Masthead

JAMA Internal Medicine

Abstract Full Text
free access
JAMA Intern Med. 2021;181(10):1274. doi:10.1001/jamainternmed.2020.5297
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