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October 2024 - January 1908

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Issue

December 2021, Vol 181, No. 12, Pages 1554-1684

Viewpoint

FDA Drug Approval and the Ethics of Desperation

Abstract Full Text
JAMA Intern Med. 2021;181(12):1555-1556. doi:10.1001/jamainternmed.2021.6045

This Viewpoint uses the accelerated approval of aducanumab to treat Alzheimer disease to discuss what role patient desperation should play in the FDA’s decision-making.

Original Investigation

Association of Statin Therapy Initiation With Diabetes Progression: A Retrospective Matched-Cohort Study

Abstract Full Text
free access
JAMA Intern Med. 2021;181(12):1562-1574. doi:10.1001/jamainternmed.2021.5714

This national matched-cohort study explores the association between statin therapy initiation and progression of diabetes among patients with diabetes.

Assessment of Nonfatal Myocardial Infarction as a Surrogate for All-Cause and Cardiovascular Mortality in Treatment or Prevention of Coronary Artery Disease: A Meta-analysis of Randomized Clinical Trials

Abstract Full Text
free access
JAMA Intern Med. 2021;181(12):1575-1587. doi:10.1001/jamainternmed.2021.5726

This meta-analysis of randomized clinical trials examines the use of myocardial infarction as a surrogate for all-cause or cardiovascular mortality in patients with or at risk for cardiovascular disease.

Association Between Risk of COVID-19 Infection in Nonimmune Individuals and COVID-19 Immunity in Their Family Members

Abstract Full Text
open access
JAMA Intern Med. 2021;181(12):1589-1595. doi:10.1001/jamainternmed.2021.5814

This cohort study examines the spread of COVID-19 infection within family members living in the same residence with different levels of immunity.

Real-world Use of and Spending on New Oral Targeted Cancer Drugs in the US, 2011-2018

Abstract Full Text
free access
JAMA Intern Med. 2021;181(12):1596-1604. doi:10.1001/jamainternmed.2021.5983

This cross-sectional examines the use of and spending on oral cancer drugs by the level of benefit shown in randomized clinical trials.

Health Care Policy and Law

Patient and Payer Incentives to Use Patented Brand-Name Drugs vs Authorized Generic Drugs in Medicare Part D

Abstract Full Text
free access
JAMA Intern Med. 2021;181(12):1605-1611. doi:10.1001/jamainternmed.2021.5997

This cross-sectional study of Medicare Prescription Drug Plan Formulary and Pricing Information Files and Medicare Part D plan enrollment assessed examined coverage for 4 brand-name insulin drugs and direct-acting antiviral agents and their authorized generic formulations.

Efficacy and Safety of Therapeutic-Dose Heparin vs Standard Prophylactic or Intermediate-Dose Heparins for Thromboprophylaxis in High-risk Hospitalized Patients With COVID-19: The HEP-COVID Randomized Clinical Trial

Abstract Full Text
free access has audio
JAMA Intern Med. 2021;181(12):1612-1620. doi:10.1001/jamainternmed.2021.6203

This randomized clinical trial evaluates the effects of therapeutic-dose low-molecular-weight heparin vs standard prophylactic or intermediate-dose heparins for thromboprophylaxis in high-risk hospitalized patients with COVID-19.

Risk of Guillain-Barré Syndrome Following Recombinant Zoster Vaccine in Medicare Beneficiaries

Abstract Full Text
free access has active quiz
JAMA Intern Med. 2021;181(12):1623-1630. doi:10.1001/jamainternmed.2021.6227

This case series cohort study examines the association of onset of Guillain-Barré Syndrome following vaccination with the recombinant zoster vaccine in Medicare beneficiaries.

Editorial

Conflicts of Interest and Authors of Commentaries in Medical Journals

Abstract Full Text
JAMA Intern Med. 2021;181(12):1557-1558. doi:10.1001/jamainternmed.2021.4587

Point-of-Care Ultrasonography: Visually Satisfying Medicine or Evidence-Based Medicine?

Abstract Full Text
JAMA Intern Med. 2021;181(12):1558-1559. doi:10.1001/jamainternmed.2021.5831

COVID-19 Messenger RNA Vaccination and Myocarditis—A Rare and Mostly Mild Adverse Effect

Abstract Full Text
free access
JAMA Intern Med. 2021;181(12):1560. doi:10.1001/jamainternmed.2021.5634

Racial and Ethnic Differences in Age at Diabetes Diagnosis—A Call for Action

Abstract Full Text
JAMA Intern Med. 2021;181(12):1560-1561. doi:10.1001/jamainternmed.2021.4949
Invited Commentary

Anticoagulant Therapy in Patients Hospitalized With COVID-19

Abstract Full Text
free access
JAMA Intern Med. 2021;181(12):1621-1622. doi:10.1001/jamainternmed.2021.6212
Editor's Note

Nonfatal Myocardial Infarction—Poor Surrogate for Mortality

Abstract Full Text
JAMA Intern Med. 2021;181(12):1588. doi:10.1001/jamainternmed.2021.5713

Appropriate Opioid Prescribing for Acute Pain

Abstract Full Text
JAMA Intern Med. 2021;181(12):1657-1658. doi:10.1001/jamainternmed.2021.4280

COVID-19 Vaccination Coverage Among Nursing Home Staff

Abstract Full Text
free access
JAMA Intern Med. 2021;181(12):1672-1673. doi:10.1001/jamainternmed.2021.5897
Teachable Moment

Physician Work Environment and Well-Being

Addressing Biased Patient Behavior: A Teachable Moment

Abstract Full Text
JAMA Intern Med. 2021;181(12):1631-1632. doi:10.1001/jamainternmed.2021.5719

This Teachable Moment describes ways to handle biased behavior from patients.

Less Is More

Preoperative Stress Testing Before Elective Arthroplasty: A Teachable Moment

Abstract Full Text
JAMA Intern Med. 2021;181(12):1633-1634. doi:10.1001/jamainternmed.2021.5834

This Teachable Moment discusses the role of cardiac stress testing in patients who are undergoing total hip or knee arthroplasty.

Closing the Osteoporosis Care Gap: A Teachable Moment

Abstract Full Text
has active quiz
JAMA Intern Med. 2021;181(12):1635-1636. doi:10.1001/jamainternmed.2021.5972

This Teachable Moment describes the lack of appropriate treatment for osteoporosis after a patient’s initial fragility fracture, which unnecessarily increases the common, costly, and morbid risks of refracture.

Reconsidering Reliance on Confirmatory Drug Testing in a Patient With Repeated Positive Urine Drug Screen Results: A Teachable Moment

Abstract Full Text
JAMA Intern Med. 2021;181(12):1637-1638. doi:10.1001/jamainternmed.2021.6215

This Teachable Moment illustrates the repercussions of misinterpreted drug testing results and advocates for reconsideration of routine urine drug screening in the absence of other indicators of relapse.

Research Letter

Health Care Policy and Law

Association of State Opioid Prescription Duration Limits With Changes in Opioid Prescribing for Medicare Beneficiaries

Abstract Full Text
free access
JAMA Intern Med. 2021;181(12):1656-1657. doi:10.1001/jamainternmed.2021.4281

This cohort study uses Medicare Part D data to examine whether there is an association between the implementation of state limits on opioid prescription duration and changes in prescribing.

Association of the COVID-19 Pandemic With the Prevalence of Homebound Older Adults in the United States, 2011-2020

Abstract Full Text
free access
JAMA Intern Med. 2021;181(12):1658-1660. doi:10.1001/jamainternmed.2021.4456

This cohort study evaluates the prevalence of homebound older adults in the US from 2011 to 2020 and assesses whether the COVID-19 pandemic was associated with a change in prevalence.

Association of Vaccine Type and Prior SARS-CoV-2 Infection With Symptoms and Antibody Measurements Following Vaccination Among Health Care Workers

Abstract Full Text
open access
JAMA Intern Med. 2021;181(12):1660-1662. doi:10.1001/jamainternmed.2021.4580

This cohort study evaluates symptoms following vaccination and antibody measurements in hospital workers who received an mRNA SARS-CoV-2 vaccine and had prior SARS-CoV-2 infection.

Financial Associations Between Authors of Commentaries on Randomized Clinical Trials of Invasive Cardiovascular Interventions and Trial Sponsors

Abstract Full Text
free access
JAMA Intern Med. 2021;181(12):1662-1665. doi:10.1001/jamainternmed.2021.4584

This cross-sectional study examines the financial associations between authors of commentaries on randomized clinical trials of invasive cardiovascular interventions and trial sponsors, and whether the financial associations were disclosed.

Trends in Breast Cancer Screening Costs Among Privately Insured Women Aged 40 to 64 Years

Abstract Full Text
free access
JAMA Intern Med. 2021;181(12):1665-1668. doi:10.1001/jamainternmed.2021.4832

This cohort study characterizes changes in breast cancer screening costs as digital breast tomosynthesis has been adopted at both the patient and population levels.

Acute Myocarditis Following COVID-19 mRNA Vaccination in Adults Aged 18 Years or Older

Abstract Full Text
free access
JAMA Intern Med. 2021;181(12):1668-1670. doi:10.1001/jamainternmed.2021.5511

This cohort study examines the incidence and clinical outcomes of acute myocarditis among adults following mRNA vaccination in an integrated health care system in the US.

Association of Nursing Home Characteristics With Staff and Resident COVID-19 Vaccination Coverage

Abstract Full Text
free access
JAMA Intern Med. 2021;181(12):1670-1672. doi:10.1001/jamainternmed.2021.5890

This cross-sectional study examines associations of nursing home characteristics with COVID-19 vaccination rates among nursing home staff and residents.

Health Care Policy and Law

Estimated Medicare Spending on Cancer Drug Indications With a Confirmed Lack of Clinical Benefit After US Food and Drug Administration Accelerated Approval

Abstract Full Text
free access
JAMA Intern Med. 2021;181(12):1673-1675. doi:10.1001/jamainternmed.2021.5989

This exploratory study assesses estimated Medicare spending on 10 cancer drug indications that lacked overall survival benefit after receiving US Food and Drug Administration accelerated approval.

Challenges in Clinical Electrocardiography

Two Wrongs Do Not Always Make a Right

Abstract Full Text
JAMA Intern Med. 2021;181(12):1639-1640. doi:10.1001/jamainternmed.2021.4436

This case report describes a patient in their 70s with chest discomfort that was sudden in onset and retrosternal.

Brugada Electrocardiographic Pattern in an Older Man With Syncope

Abstract Full Text
JAMA Intern Med. 2021;181(12):1641-1642. doi:10.1001/jamainternmed.2021.4838

This case report presents the electrocardiographic findings in a 61-year-old man who experienced sudden dyspnea and syncope 1 day after benign prostatic hyperplasia surgery.

Wide Complex Tachycardia With Unexpected Break in the Negative QRS Concordance in the Chest Leads: A Manifestation of the Littmann Concept

Abstract Full Text
JAMA Intern Med. 2021;181(12):1643-1644. doi:10.1001/jamainternmed.2021.5119

This case report presents the electrocardiographic findings in a 74-year-old woman with hypertension who presented with palpitations and chest discomfort and no history of angina, myocardial infarction, or dysrhythmia.

Abnormal Electrocardiograms After Diarrhea and Syncope in the Emergency Department

Abstract Full Text
JAMA Intern Med. 2021;181(12):1645-1646. doi:10.1001/jamainternmed.2021.5393

This case report presents the electrocardiographic findings for an 80-year-old man who presented to the emergency department with syncope 1 hour prior and severe vomiting and diarrhea over the past 3 days.

Evolution of de Winter Into Wellens on Electrocardiogram—What Happened?

Abstract Full Text
JAMA Intern Med. 2021;181(12):1647-1649. doi:10.1001/jamainternmed.2021.5734

This case report describes a man in his 50s with an hour of acute, severe precordial chest that was radiating to their left arm, sweating, nausea, and a 5-year history of hypertension.

An Unusual Cause of Complete Atrioventricular Block in a Patient With Pedal Swelling

Abstract Full Text
JAMA Intern Med. 2021;181(12):1650-1651. doi:10.1001/jamainternmed.2021.5968

This case report presents the electrocardiographic and echocardiographic findings of a patient in their 50s who presented with a 6-month history of pedal swelling and a 2-day history of dyspnea.

Transient ST-Segment Elevation and QTc Interval Prolongation in a Patient With Persistent Chest Pain

Abstract Full Text
JAMA Intern Med. 2021;181(12):1652-1653. doi:10.1001/jamainternmed.2021.6015

This case report presents the electrocardiographic findings in a patient in their 50s with a history of hypertension who had persistent chest pain and normal vital signs except for elevated blood pressure.

An Underrecognized Cause of Diffuse T-Wave Inversion

Abstract Full Text
JAMA Intern Med. 2021;181(12):1654-1655. doi:10.1001/jamainternmed.2021.6388

This case report presents the electrocardiographic findings of a patient in their 40s with a history of hypertension and smoking who presented to the emergency department with sudden-onset palpitations and chest tightness after an argument.

JAMA Internal Medicine Patient Page

I Am Worried About Falling: What Do I Need to Know?

Abstract Full Text
free access
JAMA Intern Med. 2021;181(12):1684. doi:10.1001/jamainternmed.2021.6175

This Patient Page summarizes prevention techniques for people who are afraid of falling and likely to fall.

Comment & Response

Tachycardia-Dependent Paroxysmal Atrioventricular Block

Abstract Full Text
JAMA Intern Med. 2021;181(12):1675-1676. doi:10.1001/jamainternmed.2021.5965

Tachycardia-Dependent Paroxysmal Atrioventricular Block—Reply

Abstract Full Text
JAMA Intern Med. 2021;181(12):1676-1677. doi:10.1001/jamainternmed.2021.5962

ST-Segment Depression in V2 With Precordial Hyperacute T-Waves Is an Anterior ST-Segment Elevation Myocardial Infarction (STEMI) Equivalent

Abstract Full Text
JAMA Intern Med. 2021;181(12):1677. doi:10.1001/jamainternmed.2021.6178

ST-Segment Depression in V2 With Precordial Hyperacute T-Waves Is an Anterior ST-Segment Elevation Myocardial Infarction (STEMI) Equivalent—Reply

Abstract Full Text
JAMA Intern Med. 2021;181(12):1677-1678. doi:10.1001/jamainternmed.2021.6181

Association of Cycling With All-Cause and Cardiovascular Disease Mortality Among Persons With Diabetes

Abstract Full Text
JAMA Intern Med. 2021;181(12):1678. doi:10.1001/jamainternmed.2021.6275
  • Editor's Note
    Cycling for Health
    JAMA Intern Med

Association of Cycling With All-Cause and Cardiovascular Disease Mortality Among Persons With Diabetes—Reply

Abstract Full Text
JAMA Intern Med. 2021;181(12):1678-1679. doi:10.1001/jamainternmed.2021.6272
  • Editor's Note
    Cycling for Health
    JAMA Intern Med
Correction

Error in Email Address

Abstract Full Text
free access
JAMA Intern Med. 2021;181(12):1679. doi:10.1001/jamainternmed.2021.6248
JAMA Internal Medicine Masthead

JAMA Internal Medicine

Abstract Full Text
free access
JAMA Intern Med. 2021;181(12):1554. doi:10.1001/jamainternmed.2020.5309
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