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October 2024 - July 1959

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Issue

July 2023, Vol 80, No. 7, Pages 656-761

Viewpoint

Incorporating the Central Vein Sign Into the Diagnostic Criteria for Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2023;80(7):657-658. doi:10.1001/jamaneurol.2023.0717

This Viewpoint discusses incorporating the central vein sign into the diagnostic criteria for multiple sclerosis.

Advocating for Demonstration of Disease Modification—Have We Been Approaching Clinical Trials in Early Alzheimer Disease Incorrectly?

Abstract Full Text
JAMA Neurol. 2023;80(7):659-660. doi:10.1001/jamaneurol.2023.0815

This Viewpoint discusses the benefits of clinical trials with a delayed-start design and analysis of downstream biomarkers to examine whether antimyeloid immunotherapy changes the course of early Alzheimer disease.

On the Brain

Paean to Physicians’ Patient Notes

Abstract Full Text
JAMA Neurol. 2023;80(7):661-662. doi:10.1001/jamaneurol.2023.1495

This essay discusses the value of the detail-filled notes physicians were trained to write after each patient encounter, and how those notes are now viewed mostly as instruments for billing instead of as vital information for ongoing patient care.

Editorial

The Water, the Air, the Marines—Camp Lejeune, Trichloroethylene, and Parkinson Disease

Abstract Full Text
JAMA Neurol. 2023;80(7):663-665. doi:10.1001/jamaneurol.2023.1174

Myocardial Infarction Bends the Curve of Age-Related Cognitive Decline, but How?

Abstract Full Text
JAMA Neurol. 2023;80(7):665-667. doi:10.1001/jamaneurol.2023.0466

Making Sure Multiple Sclerosis Counts and Is Counted for All—An Update on Multiple Sclerosis Prevalence by Race and Ethnicity in the United States

Abstract Full Text
JAMA Neurol. 2023;80(7):667-669. doi:10.1001/jamaneurol.2023.0469

Is Autologous Hematopoietic Stem Cell Transplant Better Than High-Efficacy Disease-Modifying Therapies for Relapsing Multiple Sclerosis?

Abstract Full Text
JAMA Neurol. 2023;80(7):669-672. doi:10.1001/jamaneurol.2023.0467
Original Investigation

Risk of Parkinson Disease Among Service Members at Marine Corps Base Camp Lejeune

Abstract Full Text
free access has audio
JAMA Neurol. 2023;80(7):673-681. doi:10.1001/jamaneurol.2023.1168

This cohort study assesses the association between the contaminated water supply at Camp Lejeune and incidence of Parkinson disease among veterans who resided there between 1975 and 1985.

Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease: The Lacunar Intervention Trial-2 (LACI-2) Randomized Clinical Trial

Abstract Full Text
open access
JAMA Neurol. 2023;80(7):682-692. doi:10.1001/jamaneurol.2023.1526

This randomized clinical trial examines treatment outcomes with isosorbide mononitrate and cilostazol in patients with symptomatic cerebral small vessel disease.

Population-Based Estimates for the Prevalence of Multiple Sclerosis in the United States by Race, Ethnicity, Age, Sex, and Geographic Region

Abstract Full Text
open access
JAMA Neurol. 2023;80(7):693-701. doi:10.1001/jamaneurol.2023.1135

This cohort study analyzes data from representative private, military, and public health insurance data sets to calculate the national prevalence of multiple sclerosis among Hispanic, non-Hispanic Black, and non-Hispanic White individuals in the United States.

Comparative Effectiveness of Autologous Hematopoietic Stem Cell Transplant vs Fingolimod, Natalizumab, and Ocrelizumab in Highly Active Relapsing-Remitting Multiple Sclerosis

Abstract Full Text
free access
JAMA Neurol. 2023;80(7):702-713. doi:10.1001/jamaneurol.2023.1184

This comparative effectiveness research study compares autologous hematopoietic stem cell transplant (AHSCT) vs fingolimod, natalizumab, and ocrelizumab for patients with relapsing-remitting multiple sclerosis.

Safety and Efficacy of Dual Thrombolytic Therapy With Mutant Prourokinase and Small Bolus Alteplase for Ischemic Stroke: A Randomized Clinical Trial

Abstract Full Text
free access
JAMA Neurol. 2023;80(7):714-722. doi:10.1001/jamaneurol.2023.1262

This randomized clinical trial of individuals with ischemic stroke assesses the safety and efficacy of treatment with a dual plasminogen activator vs usual treatment with intravenous alteplase.

Association Between Acute Myocardial Infarction and Cognition

Abstract Full Text
free access
JAMA Neurol. 2023;80(7):723-731. doi:10.1001/jamaneurol.2023.1331

This cohort study uses pooled data from 6 US population-based cohort studies to assess whether incident myocardial infarction is associated with changes in cognition immediately after in the years following the event.

Symptomatic Intracranial Hemorrhage With Tenecteplase vs Alteplase in Patients With Acute Ischemic Stroke: The Comparative Effectiveness of Routine Tenecteplase vs Alteplase in Acute Ischemic Stroke (CERTAIN) Collaboration

Abstract Full Text
free access
JAMA Neurol. 2023;80(7):732-738. doi:10.1001/jamaneurol.2023.1449

This cohort study evaluates rates of symptomatic intracranial hemorrhage following stroke with tenecteplase vs alteplase.

Comparison Between Dimethyl Fumarate, Fingolimod, and Ocrelizumab After Natalizumab Cessation

Abstract Full Text
free access
JAMA Neurol. 2023;80(7):739-748. doi:10.1001/jamaneurol.2023.1542

This cohort study investigates differences in the effectiveness and treatment persistence between dimethyl fumarate, fingolimod, and ocrelizumab among patients with relapsing-remitting multiple sclerosis who switched from natalizumab.

Clinical Utility of Tau Positron Emission Tomography in the Diagnostic Workup of Patients With Cognitive Symptoms

Abstract Full Text
open access
JAMA Neurol. 2023;80(7):749-756. doi:10.1001/jamaneurol.2023.1323

This study aims to prospectively study the added clinical value of positron emission tomography detecting tau pathology in Alzheimer disease.

Images in Neurology

Ultrasonography of Muscle Vibration Caused by MYBPC1 Variant

Abstract Full Text
has active quiz has multimedia
JAMA Neurol. 2023;80(7):757. doi:10.1001/jamaneurol.2023.0818

This case report describes muscle vibration during muscle contraction caused by an MYBPC1 variant.

Computed Tomography Findings in Hyperacute Spontaneous Midbrain Hemorrhage

Abstract Full Text
has active quiz
JAMA Neurol. 2023;80(7):758-759. doi:10.1001/jamaneurol.2023.1046

This case report describes the computed tomography (CT) characteristic findings and evolution of a hyperacute spontaneous midbrain hemorrhage.

JAMA Neurology Clinical Challenge

Posterior Reversible Encephalopathy Syndrome in a Child With Renovascular Hypertension

Abstract Full Text
has active quiz
JAMA Neurol. 2023;80(7):760-761. doi:10.1001/jamaneurol.2023.1501

A 6-year-old child presented with headache for 1 month and seizures followed by altered consciousness for 1 day. He had new-onset daily occipital headache for 1 month of mild to moderate severity and pulsating character. What is your diagnosis?

JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2023;80(7):656. doi:10.1001/jamaneurol.2022.4089
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