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October 2024 - July 1959

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Issue

June 2023, Vol 80, No. 6, Pages 540-648

Viewpoint

An Integrated Interdisciplinary Sleep Care Model—The Ultimate Dream Team

Abstract Full Text
JAMA Neurol. 2023;80(6):541-542. doi:10.1001/jamaneurol.2023.0549

This Viewpoint discusses the need for diverse physicians to manage sleep health.

Challenges and Opportunities for the Promising Biomarker Blood Neurofilament Light Chain

Abstract Full Text
JAMA Neurol. 2023;80(6):542-543. doi:10.1001/jamaneurol.2023.0394

This Viewpoint describes the benefits and limitations of using neurofilament light chain (NfL) as a marker of real-time disease activity and treatment response in multiple sclerosis.

On the Brain

The Cynicism of the Seronegative

Abstract Full Text
JAMA Neurol. 2023;80(6):544-545. doi:10.1001/jamaneurol.2023.0929

A physician in his 60s describes his path to a diagnosis of inflammatory arthritis, which included completely normal laboratory results.

Editorial

Oncogenic Pathways Provide Clue to the Etiology of Human Mesial Temporal Lobe Epilepsy

Abstract Full Text
JAMA Neurol. 2023;80(6):546-547. doi:10.1001/jamaneurol.2023.0465
Original Investigation

Clinical Effect of Early vs Late Amyloid Positron Emission Tomography in Memory Clinic Patients: The AMYPAD-DPMS Randomized Clinical Trial

Abstract Full Text
open access
JAMA Neurol. 2023;80(6):548-557. doi:10.1001/jamaneurol.2023.0997

This randomized clinical trial compares data for the timing of amyloid positron emission tomography for patients with concerns about cognitive decline to determine its clinical effect early in the diagnostic workup (within 1 month).

Efficacy and Safety of Avalglucosidase Alfa in Patients With Late-Onset Pompe Disease After 97 Weeks: A Phase 3 Randomized Clinical Trial

Abstract Full Text
open access
JAMA Neurol. 2023;80(6):558-567. doi:10.1001/jamaneurol.2023.0552

This randomized clinical trial extension evaluates efficacy and safety outcomes of avalglucosidase alfa treatment in patients with late-onset Pompe disease.

Prenatal Exposure to Antiseizure Medication and Incidence of Childhood- and Adolescence-Onset Psychiatric Disorders

Abstract Full Text
free access has audio
JAMA Neurol. 2023;80(6):568-577. doi:10.1001/jamaneurol.2023.0674

This cohort study of children of mothers with epilepsy examines whether prenatal exposure to common prenatal antiseizure medication is associated with a broad spectrum of psychiatric disorders in childhood and adolescence.

Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy

Abstract Full Text
open access
JAMA Neurol. 2023;80(6):578-587. doi:10.1001/jamaneurol.2023.0473

This genetic association study evaluates the association between pathogenic somatic variants in the hippocampus and mesial temporal lobe epilepsy.

Focal Cortex Stimulation With a Novel Implantable Device and Antiseizure Outcomes in 2 Prospective Multicenter Single-Arm Trials

Abstract Full Text
open access
JAMA Neurol. 2023;80(6):588-596. doi:10.1001/jamaneurol.2023.0066

This pooled analysis of 2 nonrandomized uncontrolled trials investigates the association between epicranial electrical focal cortex stimulation and seizure frequency in drug-refractory focal epilepsy.

Glycemic Control Over Multiple Decades and Dementia Risk in People With Type 2 Diabetes

Abstract Full Text
free access
JAMA Neurol. 2023;80(6):597-604. doi:10.1001/jamaneurol.2023.0697

This cohort study examines associations between cumulative exposure to various ranges of glycated hemoglobin concentrations and dementia risk among adults aged 50 years or older with type 2 diabetes.

Association of Mortality and Risk of Epilepsy With Type of Acute Symptomatic Seizure After Ischemic Stroke and an Updated Prognostic Model

Abstract Full Text
free access
JAMA Neurol. 2023;80(6):605-613. doi:10.1001/jamaneurol.2023.0611

This cohort study examines data for patients with acute ischemic stroke to compare the risk of poststroke mortality and epilepsy between different types of acute symptomatic seizures.

Comparison of Group-Level and Individualized Brain Regions for Measuring Change in Longitudinal Tau Positron Emission Tomography in Alzheimer Disease

Abstract Full Text
open access
JAMA Neurol. 2023;80(6):614-623. doi:10.1001/jamaneurol.2023.1067

This cohort study investigates if defining participant-level regions of interest improves sensitivity to tau accumulation on positron emission tomography compared with group-level regions of interest.

Characteristics of Progressive Multifocal Leukoencephalopathy Associated With Sarcoidosis Without Therapeutic Immune Suppression

Abstract Full Text
free access
JAMA Neurol. 2023;80(6):624-633. doi:10.1001/jamaneurol.2023.0841

This case series examines data for patients from 8 US medical centers to determine and describe the characteristics associated with progressive multifocal leukoencephalopathy in the context of sarcoidosis, including neurological symptoms and changes seen on brain magnetic resonance imaging.

Rheumatoid Arthritis and Risk of Parkinson Disease in Korea

Abstract Full Text
free access
JAMA Neurol. 2023;80(6):634-641. doi:10.1001/jamaneurol.2023.0932

This cohort study evaluates the associations of rheumatoid arthritis and its seropositivity with subsequent Parkinson disease risk in a nationally representative Korean population.

Images in Neurology

Severe Hippocampal Atrophy in a Patient With Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy

Abstract Full Text
has active quiz
JAMA Neurol. 2023;80(6):642-643. doi:10.1001/jamaneurol.2023.0606

This case report describes a patient who presented with headache, fever, quadriparesis, and reduced visual acuity in the left eye and 6 months later presented with persistent quadriparesis and new-onset cognitive deficits.

Lentiform Fork Sign on Magnetic Resonance Imaging After Methamphetamine and Alcohol Misuse

Abstract Full Text
has active quiz
JAMA Neurol. 2023;80(6):644-645. doi:10.1001/jamaneurol.2023.0723

This case report describes a patient with a 3-day history of acute blindness after using alcohol and methamphetamine for 3 consecutive nights before onset of visual impairment.

Research Letter

Trends in the Prevalence of Stroke Among Community-Dwelling Individuals in the US, 1999-2018

Abstract Full Text
free access
JAMA Neurol. 2023;80(6):646-648. doi:10.1001/jamaneurol.2023.0742

This cross-sectional study estimates trends in stroke prevalence representative of the noninstitutionalized civilian population of US adults 20 years and older using data from the 1999 to 2018 National Health and Nutrition Examination Surveys.

JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2023;80(6):540. doi:10.1001/jamaneurol.2022.4085
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