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October 2024 - July 1959

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Issue

May 2023, Vol 80, No. 5, Pages 428-533

Viewpoint

A Step Forward in the Fight Against Dementia—Are We There Yet?

Abstract Full Text
JAMA Neurol. 2023;80(5):429-430. doi:10.1001/jamaneurol.2023.0123

This Viewpoint reports on the results of the Clarity AD trial, a phase 3 randomized clinical trial of lecanemab for patients with early Alzheimer disease, in which lecanemab’s clinical efficacy was demonstrated using well-established outcome measures.

Lecanemab and APOE Genotyping in Clinical Practice—Navigating Uncharted Terrain

Abstract Full Text
JAMA Neurol. 2023;80(5):431-432. doi:10.1001/jamaneurol.2023.0207

This Viewpoint discusses the findings of the Clarity AD trial, which studied lecanemab for patients with early-stage Alzheimer disease.

On the Brain

Hello, My Name is Doctor

Abstract Full Text
JAMA Neurol. 2023;80(5):433. doi:10.1001/jamaneurol.2023.0356

This essay describes a physician’s opinion of why using only a first name can be confusing rather than aiding in resolving inequalities between physicians and other hospital staff or patients.

Editorial

JAMA Neurology—The Year in Review, 2022

Abstract Full Text
free access
JAMA Neurol. 2023;80(5):434-435. doi:10.1001/jamaneurol.2023.0262

Transcarotid Artery Revascularization for Stroke Prevention—Multiple Elephants in the Room

Abstract Full Text
JAMA Neurol. 2023;80(5):435-436. doi:10.1001/jamaneurol.2023.0293
Original Investigation

Risk of Stroke, Death, and Myocardial Infarction Following Transcarotid Artery Revascularization vs Carotid Endarterectomy in Patients With Standard Surgical Risk

Abstract Full Text
free access
JAMA Neurol. 2023;80(5):437-444. doi:10.1001/jamaneurol.2023.0285

This cohort study compares risk of 30-day stroke, death, or myocardial infarction or 1-year ipsilateral stroke among patients with standard surgical risk undergoing transcarotid artery revascularization vs carotid endarterectomy.

Association of Dementia Risk With Focal Epilepsy and Modifiable Cardiovascular Risk Factors

Abstract Full Text
open access has audio
JAMA Neurol. 2023;80(5):445-454. doi:10.1001/jamaneurol.2023.0339

This cross-sectional study examines data from the UK Biobank to explore the association between focal epilepsy compared with stroke or migraine and the risk of developing dementia and how that risk is affected by modifiable cardiovascular risk factors.

Physical Frailty, Genetic Predisposition, and Incident Parkinson Disease

Abstract Full Text
free access
JAMA Neurol. 2023;80(5):455-461. doi:10.1001/jamaneurol.2023.0183

This cohort study attempts to examine the longitudinal association of frailty phenotype with the development of Parkinson disease and to explore the modification role of genetic risk of Parkinson disease in such association.

Association of Age at Menopause and Hormone Therapy Use With Tau and β-Amyloid Positron Emission Tomography

Abstract Full Text
free access
JAMA Neurol. 2023;80(5):462-473. doi:10.1001/jamaneurol.2023.0455

This cross-sectional study examines the extent to which sex, age at menopause, and hormone therapy use are associated with regional tau at a given level of β-amyloid, both measured with positron emission tomography.

Outcomes After Endovascular Therapy With Procedural Sedation vs General Anesthesia in Patients With Acute Ischemic Stroke: The AMETIS Randomized Clinical Trial

Abstract Full Text
free access
JAMA Neurol. 2023;80(5):474-483. doi:10.1001/jamaneurol.2023.0413

This randomized clinical trial evaluates whether general anesthesia or procedural sedation for anterior circulation large-vessel occlusion acute ischemic stroke thrombectomy is associated with a difference in periprocedural complications and 3-month functional outcome.

Comparison of Perinatal Outcomes for Women With and Without Epilepsy: A Systematic Review and Meta-analysis

Abstract Full Text
free access
JAMA Neurol. 2023;80(5):484-494. doi:10.1001/jamaneurol.2023.0148

This systematic review and meta-analysis compares data for women with and without epilepsy to investigate maternal, fetal, and neonatal complications and their associations with epilepsy and use of antiseizure medications.

Evaluation of Plasma Phosphorylated Tau217 for Differentiation Between Alzheimer Disease and Frontotemporal Lobar Degeneration Subtypes Among Patients With Corticobasal Syndrome

Abstract Full Text
open access
JAMA Neurol. 2023;80(5):495-505. doi:10.1001/jamaneurol.2023.0488

This cohort study evaluated the use of phosphorylated tau217 to discern between Alzheimer disease and frontotemporal lobar degeneration among patients with corticobasal syndrome.

Association Between Magnitude of Differential Blood Pressure Reduction and Secondary Stroke Prevention: A Meta-analysis and Meta-Regression

Abstract Full Text
open access
JAMA Neurol. 2023;80(5):506-515. doi:10.1001/jamaneurol.2023.0218

This meta-analysis and meta-regression of randomized clinical trials evaluates the association of magnitude of differential blood pressure reduction and recurrent stroke in patients with stroke or transient ischemic attack.

Mitigating the Associations of Kidney Dysfunction With Blood Biomarkers of Alzheimer Disease by Using Phosphorylated Tau to Total Tau Ratios

Abstract Full Text
open access
JAMA Neurol. 2023;80(5):516-522. doi:10.1001/jamaneurol.2023.0199

This cross-sectional study investigates associations of chronic kidney disease with plasma ratios of phosphorylated tau 217 and 181 to the corresponding unphosphorylated peptides in Alzheimer disease.

Brief Report

Quantification of Penumbral Volume in Association With Time From Stroke Onset in Acute Ischemic Stroke With Large Vessel Occlusion

Abstract Full Text
JAMA Neurol. 2023;80(5):523-528. doi:10.1001/jamaneurol.2023.0265

This cross-sectional study examines changes in the penumbral and core volumes over time to imaging in patients with acute ischemic stroke.

Images in Neurology

Limb to Cranial Overflow Dystonia in a Patient After Stroke

Abstract Full Text
has active quiz has multimedia
JAMA Neurol. 2023;80(5):529. doi:10.1001/jamaneurol.2023.0058

This case report describes noncontiguous overflow dystonia in a patient with diabetes, hypertension, and a history of left putaminal hemorrhage and right hemiparesis.

Multimodal Neuroimaging of Intimal Flap in a Basilar Artery Dissection

Abstract Full Text
has active quiz has multimedia
JAMA Neurol. 2023;80(5):530-531. doi:10.1001/jamaneurol.2023.0126

This case report describes a spontaneous dissection of the basilar artery in a 53-year-old man presenting with ischemic stroke.

Comment & Response

Association Between Use of Angiotensin Receptor Blockers and Incidence of Epilepsy in Patients With Hypertension

Abstract Full Text
JAMA Neurol. 2023;80(5):532. doi:10.1001/jamaneurol.2023.0404

Association Between Use of Angiotensin Receptor Blockers and Incidence of Epilepsy in Patients With Hypertension—Reply

Abstract Full Text
JAMA Neurol. 2023;80(5):532-533. doi:10.1001/jamaneurol.2023.0407
Correction

Error in Figure 3

Abstract Full Text
free access
JAMA Neurol. 2023;80(5):533. doi:10.1001/jamaneurol.2023.0594
Peer Reviewers List

JAMA Neurology Peer Reviewers in 2022

Abstract Full Text
free access online only
JAMA Neurol. 2023;80(5):e230230. doi:10.1001/jamaneurol.2023.0230
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2023;80(5):428. doi:10.1001/jamaneurol.2022.4081
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