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October 2024 - April 2015

Decade

Year

Issue

September 2022, Vol 8, No. 9, Pages 1248-1364

Original Investigation

Efficacy of Preoperative mFOLFIRINOX vs mFOLFIRINOX Plus Hypofractionated Radiotherapy for Borderline Resectable Adenocarcinoma of the Pancreas: The A021501 Phase 2 Randomized Clinical Trial

Abstract Full Text
free access
JAMA Oncol. 2022;8(9):1263-1270. doi:10.1001/jamaoncol.2022.2319

This randomized clinical trial compares treatment with neoadjuvant modified FOLFIRINOX with or without hypofractionated radiation therapy with historical data and establishes standards for therapy in borderline resectable pancreatic ductal adenocarcinoma.

Response Rate and Safety of a Neoadjuvant Pertuzumab, Atezolizumab, Docetaxel, and Trastuzumab Regimen for Patients With ERBB2-Positive Stage II/III Breast Cancer: The Neo-PATH Phase 2 Nonrandomized Clinical Trial

Abstract Full Text
open access
JAMA Oncol. 2022;8(9):1271-1277. doi:10.1001/jamaoncol.2022.2310

This nonrandomized clinical trial aims to determine whether neoadjuvant atezolizumab, docetaxel, trastuzumab, and pertuzumab therapy for ERBB2-positive early breast cancer warrants continuation to the next phase.

Elotuzumab and Weekly Carfilzomib, Lenalidomide, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Without Transplant Intent: A Phase 2 Measurable Residual Disease–Adapted Study

Abstract Full Text
free access
JAMA Oncol. 2022;8(9):1278-1286. doi:10.1001/jamaoncol.2022.2424

This measurable residual disease–adapted study examines the association of treatment with elotuzumab with weekly carfilzomib, lenalidomide, and dexamethasone without stem cell transplant with rates of stringent complete response and measurable residual disease–negativity in patients with newly diagnosed multiple myeloma.

Global Association of COVID-19 Pandemic Measures With Cancer Screening: A Systematic Review and Meta-analysis

Abstract Full Text
free access has active quiz has audio
JAMA Oncol. 2022;8(9):1287-1293. doi:10.1001/jamaoncol.2022.2617

This systematic review and meta-analysis used databases, such as PubMed, ProQuest, and Scopus, to investigate the association between the COVID-19 pandemic and decreased rates of breast, colorectal, and cervical cancer screening globally.

Log-Rank Test vs MaxCombo and Difference in Restricted Mean Survival Time Tests for Comparing Survival Under Nonproportional Hazards in Immuno-oncology Trials: A Systematic Review and Meta-analysis

Abstract Full Text
open access
JAMA Oncol. 2022;8(9):1294-1300. doi:10.1001/jamaoncol.2022.2666

This systematic review and meta-analysis compares the performance of the log-rank test vs the MaxCombo and difference in restricted mean survival time tests in immuno-oncology trials.

Association of Intratumoral Microbiota With Prognosis in Patients With Nasopharyngeal Carcinoma From 2 Hospitals in China

Abstract Full Text
open access
JAMA Oncol. 2022;8(9):1301-1309. doi:10.1001/jamaoncol.2022.2810

This multicenter cohort study analyzes the associations between intratumoral microbiota and prognostication in patients with nasopharyngeal carcinoma.

Audit of Data Sharing by Pharmaceutical Companies for Anticancer Medicines Approved by the US Food and Drug Administration

Abstract Full Text
open access
JAMA Oncol. 2022;8(9):1310-1316. doi:10.1001/jamaoncol.2022.2867

This quality improvement study audits individual participant data sharing by pharmaceutical companies for anticancer medicines approved by the US Food and Drug Administration.

Brief Report

Evaluation of Treatment With Talazoparib and Avelumab in Patients With Recurrent Mismatch Repair Proficient Endometrial Cancer

Abstract Full Text
open access
JAMA Oncol. 2022;8(9):1317-1322. doi:10.1001/jamaoncol.2022.2181

This nonrandomized clinical trial examines the potential positive outcomes and safety of the combination of talazoparib and avelumab in recurrent mismatch repair proficient endometrial cancer.

Evaluation of the Molecular Landscape of Pediatric Thyroid Nodules and Use of a Multigene Genomic Classifier in Children

Abstract Full Text
open access
JAMA Oncol. 2022;8(9):1323-1327. doi:10.1001/jamaoncol.2022.1655

This study examines whether the molecular landscape of pediatric thyroid nodules is amenable to detection by a multigene genomic classifier test.

Evaluation of Clinical Outcomes of Icotinib in Patients With Clinically Diagnosed Advanced Lung Cancer With EGFR-Sensitizing Variants Assessed by Circulating Tumor DNA Testing: A Phase 2 Nonrandomized Clinical Trial

Abstract Full Text
free access
JAMA Oncol. 2022;8(9):1328-1332. doi:10.1001/jamaoncol.2022.2719

This phase 2 nonrandomized clinical trial evaluates the clinical outcome of first-line icotinib in patients with clinically diagnosed advanced lung cancer with unknown pathological status and positive EGFR-sensitizing variants assessed by circulating tumor DNA.

Research Letter

Environmental Outcomes Associated With Transition From In-Person to a Virtual Oncology Conference During the COVID-19 Pandemic

Abstract Full Text
free access
JAMA Oncol. 2022;8(9):1351-1352. doi:10.1001/jamaoncol.2022.1925

This cohort study characterizes the potential environmental benefit associated with the transition from in-person professional conference attendance to virtual conference attendance before and during the COVID-19 pandemic.

Association Between Toxic Effects and Survival in Patients With Cancer and Autoimmune Disease Treated With Checkpoint Inhibitor Immunotherapy

Abstract Full Text
free access
JAMA Oncol. 2022;8(9):1352-1354. doi:10.1001/jamaoncol.2022.2081

This cohort study analyzed the safety and efficacy of immune checkpoint inhibitors in patients with cancer and autoimmune disease, and examined whether immune-related toxic effects were associated with outcomes.

Incidence of Anaplastic Large-Cell Lymphoma of the Breast in the US, 2000 to 2018

Abstract Full Text
free access
JAMA Oncol. 2022;8(9):1354-1356. doi:10.1001/jamaoncol.2022.2624

This cohort study of data from the Surveillance, Epidemiology, and End Results 18 database examines the incidence of anaplastic large-cell lymphoma of the breast in the US from 2000 to 2018.

Daily Insulin Dose and Cancer Risk Among Patients With Type 1 Diabetes

Abstract Full Text
free access
JAMA Oncol. 2022;8(9):1356-1358. doi:10.1001/jamaoncol.2022.2960

This cohort study examines the incidence of cancer diagnosis and risk factors among patients on a daily regimen of insulin.

Special Communication

A New Approach to Simplifying and Harmonizing Cancer Clinical Trials—Standardizing Eligibility Criteria

Abstract Full Text
has active quiz
JAMA Oncol. 2022;8(9):1333-1339. doi:10.1001/jamaoncol.2022.1664

This Special Communication presents a prioritized list of recommended terms for inclusion and exclusion criteria in first-line, therapeutic clinical trials for advanced non–small cell lung cancer that are intended to support marketing application.

Review

Treatment of Adults With Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia—From Intensive Chemotherapy Combinations to Chemotherapy-Free Regimens: A Review

Abstract Full Text
has active quiz
JAMA Oncol. 2022;8(9):1340-1348. doi:10.1001/jamaoncol.2022.2398

This Review reports current evidence for frontline therapies of Philadelphia chromosome–positive acute lymphoblastic leukemia, the major principles that guide therapy, and the progress with chemotherapy-free regimens.

JAMA Oncology Clinical Challenge

Asymptomatic Cutaneous Plaques on the Scalp and Face in an Older Adult Woman

Abstract Full Text
has active quiz
JAMA Oncol. 2022;8(9):1349-1350. doi:10.1001/jamaoncol.2022.2558

A 79-year-old female patient presented with a 2-year history of asymptomatic erythematous-infiltrated patches and plaques on the right side of her scalp and face, which gradually enlarged and coalesced into large plaques and nodules. What is your diagnosis?

Viewpoint

Starting a Career in Oncology: Fighting Cancer and Gender Disparities

Abstract Full Text
JAMA Oncol. 2022;8(9):1251-1252. doi:10.1001/jamaoncol.2022.1775

This Viewpoint calls for systemic change in the field of oncology to address gender disparities and to support and retain women oncologists.

Brain Metastasis—A Distinct Oncologic Disease Best Served by an Integrated Multidisciplinary Team Approach

Abstract Full Text
JAMA Oncol. 2022;8(9):1252-1254. doi:10.1001/jamaoncol.2022.1928

This Viewpoint discusses the identification and treatment of brain metastasis as a distinct disease and its management with a multidisciplinary approach to improve patient outcomes.

Research During Wartime—Ethical Challenges Faced by Oncology Researchers in Ukraine

Abstract Full Text
JAMA Oncol. 2022;8(9):1254-1255. doi:10.1001/jamaoncol.2022.2549

This Viewpoint discusses the ethical challenges faced by oncology researchers during the war in Ukraine.

Editorial

The Continued Struggle for Defining a Role for Radiotherapy in Pancreas Cancer

Abstract Full Text
JAMA Oncol. 2022;8(9):1257-1259. doi:10.1001/jamaoncol.2022.2309

Novel Quadruplets and the Age of Immunotherapies in the Treatment of Newly Diagnosed Multiple Myeloma

Abstract Full Text
JAMA Oncol. 2022;8(9):1260-1262. doi:10.1001/jamaoncol.2022.2421
JAMA Oncology Patient Page

Perioperative Therapy in Early-Stage Lung Cancer

Abstract Full Text
free access
JAMA Oncol. 2022;8(9):1364. doi:10.1001/jamaoncol.2022.1940

This JAMA Oncology Patient Page describes the use of systemic therapy in addition to surgery in the treatment of early-stage lung cancer.

Cancer Care Chronicles

A Musical Ode

Abstract Full Text
JAMA Oncol. 2022;8(9):1256. doi:10.1001/jamaoncol.2022.1851

This essay explores the author’s experience with music and medicine.

Poetry and Oncology

Raspberry Ice Cream

Abstract Full Text
JAMA Oncol. 2022;8(9):1362. doi:10.1001/jamaoncol.2022.1937
Comment & Response

Role of Patient-Reported Outcome Measures in the Inpatient Setting

Abstract Full Text
JAMA Oncol. 2022;8(9):1358. doi:10.1001/jamaoncol.2022.2552

Role of Patient-Reported Outcome Measures in the Inpatient Setting—Reply

Abstract Full Text
JAMA Oncol. 2022;8(9):1358-1359. doi:10.1001/jamaoncol.2022.2555
Correction

Errors in Figure 2

Abstract Full Text
free access
JAMA Oncol. 2022;8(9):1359. doi:10.1001/jamaoncol.2022.2647

Error in Results and Table 1

Abstract Full Text
free access
JAMA Oncol. 2022;8(9):1359. doi:10.1001/jamaoncol.2022.4366
JAMA Oncology Masthead

JAMA Oncology

Abstract Full Text
free access
JAMA Oncol. 2022;8(9):1248. doi:10.1001/jamaoncol.2021.5516
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