Julien Edeline, MD, PhD; Yann Touchefeu, MD; Boris Guiu, MD, PhD; et al.
free access
JAMA Oncol. 2020;6(1):51-59. doi:10.1001/jamaoncol.2019.3702
This phase 2 clinical trial measures the 3-month response rate of selective internal radiotherapy combined with chemotherapy as well as toxic effects, overall and progression-free survival, and disease control rate for patients with unresectable intrahepatic cholangiocarcinoma.
Andrea Cercek, MD; Thomas Boerner, MD; Benjamin R. Tan, MD; et al.
free access
JAMA Oncol. 2020;6(1):60-67. doi:10.1001/jamaoncol.2019.3718
This phase 2 clinical trial evaluates the use of hepatic arterial infusion of floxuridine plus systemic administration of gemcitabine and oxaliplatin in patients with unresectable intrahepatic cholangiocarcinoma.
Trasias Mukama, MPH; Elham Kharazmi, MD, PhD; Xing Xu, MSc; et al.
free access
JAMA Oncol. 2020;6(1):68-74. doi:10.1001/jamaoncol.2019.3876
This cohort study examines data from the Swedish family-cancer data sets for family history, relative’s age at diagnosis, and other factors to identify the appropriate age for breast cancer screening.
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Editorial
Toward Risk-Stratified Breast Cancer Screening: Considerations for Changes in Screening Guidelines
Gretchen L. Gierach, PhD, MPH; Parichoy Pal Choudhury, PhD; Montserrat García-Closas, MD, DrPH
JAMA Oncol
Douglas W. Arthur, MD; Kathryn A. Winter, MS; Henry M. Kuerer, MD, PhD; et al.
free access
JAMA Oncol. 2020;6(1):75-82. doi:10.1001/jamaoncol.2019.4320
This phase 2 clinical trial of patients with recurrence of breast cancer in the ipsilateral breast assesses the effectiveness of partial breast reirradiation after a second lumpectomy.
Alexander Penson, PhD; Niedzica Camacho, PhD; Youyun Zheng, BS; et al.
free access
JAMA Oncol. 2020;6(1):84-91. doi:10.1001/jamaoncol.2019.3985
This cohort study develops a machine learning algorithm, using tumors from patients with advanced cancer, to aid in the prediction and classification of tumor types.
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Editorial
Tumor Origins Through Genomic Profiles
Edison T. Liu, MD; Susan M. Mockus, PhD, MBA
JAMA Oncol
Jyoti S. Mayadev, MD; Danielle Enserro, PhD; Yvonne G. Lin, MD, MS; et al.
free access
JAMA Oncol. 2020;6(1):92-99. doi:10.1001/jamaoncol.2019.3857
This multi-institutional phase 1 clinical trial assesses the safety and tolerability of adding a course of immunotherapy after completion of chemoradiotherapy in patients with node-positive cervical cancer.
Kimberley M. Heinhuis; Matteo Carlino, BMedSc, MBBS, FRACP, PhD; Markus Joerger, MD, PhD; et al.
open access
JAMA Oncol. 2020;6(1):100-107. doi:10.1001/jamaoncol.2019.3848
This open-label, phase 1/2a study evaluates the safety and activity of fully human glucocorticoid-induced tumor necrosis factor (TNF) receptor–related protein agonist immunoglobulin G1 monoclonal antibody BMS-986156 with or without nivolumab in patients with advanced solid tumors.
Mingyang Song, MD, ScD; I-Min Lee, MD, ScD; JoAnn E. Manson, MD, DrPH; et al.
free access
JAMA Oncol. 2020;6(1):108-115. doi:10.1001/jamaoncol.2019.4587
This prespecified ancillary study of a randomized clinical trial compares the effects of daily marine ω-3 fatty acid supplementation vs placebo on risk of colorectal cancer precursors, including conventional adenomas and serrated polyps, in an average-risk US population.
George W. Sledge Jr, MD; Masakazu Toi, MD, PhD; Patrick Neven, MD, PhD; et al.
open access
JAMA Oncol. 2020;6(1):116-124. doi:10.1001/jamaoncol.2019.4782
This randomized clinical trial compared the effect of abemaciclib plus fulvestrant vs placebo plus fulvestrant on overall survival in women with hormone receptor–positive, ERBB2-negative advanced breast cancer that progressed during prior endocrine therapy.
Gayle S. Jameson, MSN, ACNP-BC, AOCN; Erkut Borazanci, MD; Hani M. Babiker, MD; et al.
free access
JAMA Oncol. 2020;6(1):125-132. doi:10.1001/jamaoncol.2019.3394
This open-label, single-arm, pilot, phase 1b/2 clinical trial assesses outcomes following treatment with nab-paclitaxel plus gemcitabine plus the platinum-based cisplatin for patients with previously untreated metastatic pancreatic ductal adenocarcinoma.
Joseph Pidala, MD, PhD; Michael Martens, PhD; Claudio Anasetti, MD; et al.
free access
online only
JAMA Oncol. 2020;6(1):e192974. doi:10.1001/jamaoncol.2019.2974
This cohort analysis examines the factors associated with successful immune suppression discontinuation in patients who undergo allogeneic hematopoietic cell transplantation and develops a model to estimate the probability of successful discontinuation.
David H. Ilson, MD, PhD; Josep Tabernero, MD, PhD; Aliaksandr Prokharau, MD; et al.
open access
online only
JAMA Oncol. 2020;6(1):e193531. doi:10.1001/jamaoncol.2019.3531
This subgroup analysis of a randomized clinical trial compares trifluridine/tipiracil treatment with placebo for progression-free and overall survival among patients with previously treated metastatic gastric or gastroesophageal junction cancer who had or had not undergone gastrectomy.