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February 2018, Vol 75, No. 2, Pages 139-260

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2018;75(2):139. doi:10.1001/jamaneurol.2017.2621
Viewpoint

Deflazacort—New Costs of an Old Medicine

Abstract Full Text
JAMA Neurol. 2018;75(2):143-144. doi:10.1001/jamaneurol.2017.3704

This Viewpoint discusses recent changes in the ownership of deflazacort, a drug important in the treatment of Duchenne muscular dystrophy, and advocates for fairer pricing.

Tocilizumab for Giant Cell Arteritis—A New Giant Step in an Old Disease

Abstract Full Text
JAMA Neurol. 2018;75(2):145-146. doi:10.1001/jamaneurol.2017.3811

This Viewpoint examines the use of tocilizumab as glucocorticoid-sparing treatment in patients with giant cell arteritis.

Evidence-Based Management of Patent Foramen Ovale in Patients With Ischemic Stroke

Abstract Full Text
JAMA Neurol. 2018;75(2):147-148. doi:10.1001/jamaneurol.2017.3982

This Viewpoint describes the results of 5 randomized clinical trials of devices that occlude patent foramen ovale, discusses the cerebrovascular outcomes associated with treatment, and outlines judicious use of closure procedures.

On the Brain

Reflecting on the Bicentennial of Mary Shelley’s Frankenstein: From Novel to Film and the 2 Brains

Abstract Full Text
JAMA Neurol. 2018;75(2):149-150. doi:10.1001/jamaneurol.2017.4000

This On the Brain article looks at Mary Shelley’s classic work Frankenstein in film adaptations and spin-offs.

Editorial

Periconceptional Folate Supplementation and the Risk of Autism Following Antiepileptic Drug Exposure

Abstract Full Text
has audio
JAMA Neurol. 2018;75(2):151-152. doi:10.1001/jamaneurol.2017.3067

Deep Brain Stimulation for Parkinson Disease Dementia: A New Frontier?

Abstract Full Text
JAMA Neurol. 2018;75(2):152-153. doi:10.1001/jamaneurol.2017.3798
Original Investigation

Association of Folic Acid Supplementation During Pregnancy With the Risk of Autistic Traits in Children Exposed to Antiepileptic Drugs In Utero

Abstract Full Text
free access has audio
JAMA Neurol. 2018;75(2):160-168. doi:10.1001/jamaneurol.2017.3897

This population-based cohort and Norwegian biobank study examines the association of folic acid supplements and maternal folate concentration in pregnancy with the frequency and degree of autistic traits in children exposed to antiepileptic drugs in utero.

Bilateral Deep Brain Stimulation of the Nucleus Basalis of Meynert for Parkinson Disease Dementia: A Randomized Clinical Trial

Abstract Full Text
free access
JAMA Neurol. 2018;75(2):169-178. doi:10.1001/jamaneurol.2017.3762

This randomized clinical trial evaluates the safety and potential symptomatic effects of deep brain stimulation of the nucleus basalis of Meynert in patients with Parkinson disease dementia.

Association of Bone Mineral Density With the Risk of Intracranial Aneurysm

Abstract Full Text
free access
JAMA Neurol. 2018;75(2):179-186. doi:10.1001/jamaneurol.2017.3431

This study evaluates the relationship between bone mineral density and intracranial aneurysm.

Effect of Different Doses of Galcanezumab vs Placebo for Episodic Migraine Prevention: A Randomized Clinical Trial

Abstract Full Text
open access
JAMA Neurol. 2018;75(2):187-193. doi:10.1001/jamaneurol.2017.3859

This randomized clinical trial evaluates the effect of 5, 50, 120, and 300 mg galcanezumab vs placebo as prophylaxis for patients with migraine.

Cortical Structures Associated With Human Blood Pressure Control

Abstract Full Text
free access has multimedia
JAMA Neurol. 2018;75(2):194-202. doi:10.1001/jamaneurol.2017.3344

This case series identifies cortical control sites for human blood pressure regulation in humans.

Prevalence of Systemic Atherosclerosis Burdens and Overlapping Stroke Etiologies and Their Associations With Long-term Vascular Prognosis in Stroke With Intracranial Atherosclerotic Disease

Abstract Full Text
free access
JAMA Neurol. 2018;75(2):203-211. doi:10.1001/jamaneurol.2017.3960

This study explores the frequency of intracranial atherosclerotic disease in patients who have had a stroke and whether it coexists with systemic atherosclerotic lesions and other stroke etiologies.

Association Between Microinfarcts and Blood Pressure Trajectories

Abstract Full Text
free access
JAMA Neurol. 2018;75(2):212-218. doi:10.1001/jamaneurol.2017.3392

This population-based study evaluates the association between blood pressure declines and microinfarcts found on autopsy in participants in the Mayo Clinic Study on Aging.

Effect of High-Intensity Treadmill Exercise on Motor Symptoms in Patients With De Novo Parkinson Disease: A Phase 2 Randomized Clinical Trial

Abstract Full Text
free access
JAMA Neurol. 2018;75(2):219-226. doi:10.1001/jamaneurol.2017.3517

This phase 2 randomized clinical trial examines the feasibility and safety of high-intensity treadmill exercise in patients with de novo Parkinson disease who are not taking medication and whether the effect on the motor system warrants a phase 3 trial.

Associations Between Tau, β-Amyloid, and Cognition in Parkinson Disease

Abstract Full Text
free access
JAMA Neurol. 2018;75(2):227-235. doi:10.1001/jamaneurol.2017.3713

This case-control study evaluates the associations between β-amyloid, tau pathology, and cognition by comparing cognitively normal and mildly cognitively impaired patients with Parkinson disease with healthy control participants.

Early Cognitive, Structural, and Microstructural Changes in Presymptomatic C9orf72 Carriers Younger Than 40 Years

Abstract Full Text
free access
JAMA Neurol. 2018;75(2):236-245. doi:10.1001/jamaneurol.2017.4266

This multicenter cross-sectional study assesses the occurrence of cognitive, structural, and microstructural changes in presymptomatic carriers of C9orf72 mutation.

Review

A Review of the Current Therapies, Challenges, and Future Directions of Transcranial Focused Ultrasound Technology: Advances in Diagnosis and Treatment

Abstract Full Text
JAMA Neurol. 2018;75(2):246-254. doi:10.1001/jamaneurol.2017.3129

This review reports the ablative and nonablative applications of transcranial focused ultrasound for neurological conditions.

Images in Neurology

Pisa Syndrome in a Child With Subacute Sclerosing Panencephalitis

Abstract Full Text
has multimedia
JAMA Neurol. 2018;75(2):255-256. doi:10.1001/jamaneurol.2017.4092

This case reports describes Pisa syndrome in a child with subacute sclerosing panencephalitis.

Comment & Response

Emergency Department Stroke Care

Abstract Full Text
JAMA Neurol. 2018;75(2):257. doi:10.1001/jamaneurol.2017.3814

Emergency Department Stroke Care

Abstract Full Text
JAMA Neurol. 2018;75(2):257-258. doi:10.1001/jamaneurol.2017.3817

Emergency Department Stroke Care—Reply

Abstract Full Text
JAMA Neurol. 2018;75(2):258. doi:10.1001/jamaneurol.2017.3820

New Criteria Needed for Antisynthetase Syndrome

Abstract Full Text
JAMA Neurol. 2018;75(2):258-259. doi:10.1001/jamaneurol.2017.3872

New Criteria Needed for Antisynthetase Syndrome—Reply

Abstract Full Text
JAMA Neurol. 2018;75(2):259-260. doi:10.1001/jamaneurol.2017.3875
Correction

Errors in Text

Abstract Full Text
free access
JAMA Neurol. 2018;75(2):260. doi:10.1001/jamaneurol.2017.3996

Incorrect Conflicts of Interest Disclosures

Abstract Full Text
free access
JAMA Neurol. 2018;75(2):260. doi:10.1001/jamaneurol.2017.4984
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2018;75(2):140. doi:10.1001/jamaneurol.2017.2622
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