Kayla M.D. Cornett, BHK, MSc; Manoj P. Menezes, MBBS, FRACP, PhD; Paula Bray, PhD; et al.
free access
JAMA Neurol. 2016;73(6):645-651. doi:10.1001/jamaneurol.2016.0171
This cross-sectional study assesses the variability of disease severity in a large cohort of children and adolescents with Charcot-Marie-Tooth disease.
Adam Bryant, MD; Harold Atkins, MD, FRCPC; C. Elizabeth Pringle, MD; et al.
free access
JAMA Neurol. 2016;73(6):652-658. doi:10.1001/jamaneurol.2016.0113
This study reports 7 cases of severe myasthenia gravis treated with autologous hematopoietic stem cell transplant in which consistent, durable, symptom-free, and treatment-free remission was achieved.
Paul Geha, MD; Yang Yang, PhD; Mark Estacion, PhD; et al.
free access
has audio
JAMA Neurol. 2016;73(6):659-667. doi:10.1001/jamaneurol.2016.0389
This double-blind, cross-over study of carbamazepine in 2 patients with inherited erythromelalgia aims to determine whether pain can be attenuated via pharmacotherapy guided by genomic analysis and functional profiling.
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Podcast:
Pharmacotherapy for Pain in Inherited Erythromelalgia (JAMA Neurology)
Mika H. Martikainen, MD, PhD; Yi Shiau Ng, MRCP; Gráinne S. Gorman, PhD, FRCP; et al.
free access
JAMA Neurol. 2016;73(6):668-674. doi:10.1001/jamaneurol.2016.0355
This cohort study describes the phenotype, genetic etiology, and investigation of extrapyramidal movement disorders in pediatric and adult patients with mitochondrial disease.
Georgios Tsivgoulis, MD; Ramin Zand, MD; Aristeidis H. Katsanos, MD; et al.
free access
JAMA Neurol. 2016;73(6):675-683. doi:10.1001/jamaneurol.2016.0292
This meta-analysis investigates the association of high cerebral microbleed burden with the risk of symptomatic intracerebral hemorrhage in patients with acute ischemic stroke treated with intravenous thrombolysis.
Mohammad A. Khoshnoodi, MD; Shaun Truelove, BA; Ahmet Burakgazi, MD; et al.
free access
JAMA Neurol. 2016;73(6):684-690. doi:10.1001/jamaneurol.2016.0057
This case-control study compares the longitudinal rate and pattern of intraepidermal nerve fiber density change in idiopathic small fiber neuropathy (SFN), impaired glucose tolerance鈥揳ssociated SFN, and diabetes mellitus鈥揳ssociated SFN.
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Editorial
Understanding Small Fiber Neuropathy: The Long and Short of It
John T. Kissel, MD; A. Gordon Smith, MD
JAMA Neurol
Jennifer S. Yokoyama, PhD; Yunpeng Wang, PhD; Andrew J. Schork, MS; et al.
free access
JAMA Neurol. 2016;73(6):691-697. doi:10.1001/jamaneurol.2016.0150
This genetic epidemiology study examines whether there is an association between genetic traits for immune-mediated diseases that promote inflammation and Alzheimer disease.
Anja Soldan, PhD; Corinne Pettigrew, PhD; Qing Cai, MS; et al.
free access
JAMA Neurol. 2016;73(6):698-705. doi:10.1001/jamaneurol.2016.0194
This cohort study of 4 hypothetical preclinical Alzheimer disease groups identifies which group of cognitively normal individuals shows the greatest cognitive decline over time based on their cerebrospinal fluid biomarker profile.
Takahiro Iizuka, MD; Juntaro Kaneko, MD; Naomi Tominaga, MD; et al.
free access
JAMA Neurol. 2016;73(6):706-713. doi:10.1001/jamaneurol.2016.0232
This observational study examines long-term outcomes in patients with anti-N-methyl-d-aspartate receptor encephalitis.
Eugenia Martinez-Hernandez, MD, PhD; Helena Ariño, MD; Andrew McKeon, MD; et al.
free access
JAMA Neurol. 2016;73(6):714-720. doi:10.1001/jamaneurol.2016.0133
This case-series study reports the clinical and immunologic findings in a cohort of patients with stiff-person spectrum disorder, including stiff-person syndrome, stiff-limb syndrome, or stiff-person syndrome plus progressive encephalomyelitis with rigidity, myoclonus, or other symptoms.
Shannon L. Risacher, PhD; Brenna C. McDonald, PsyD, MBA; Eileen F. Tallman, BS; et al.
free access
JAMA Neurol. 2016;73(6):721-732. doi:10.1001/jamaneurol.2016.0580
This study assesses the association between anticholinergic medication use and cognition, glucose metabolism, and brain atrophy in cognitively normal older adults from the Alzheimer鈥檚 Disease Neuroimaging Initiative and the Indiana Memory and Aging Study.
Miguel A. Santos-Santos, MD; Maria Luisa Mandelli, PhD; Richard J. Binney, PhD; et al.
free access
JAMA Neurol. 2016;73(6):733-742. doi:10.1001/jamaneurol.2016.0412
This clinical-pathological study characterizes the neurological, cognitive, and neuroimaging features of patients with nonfluent/agrammatic primary progressive aphasia鈥攊n whom either progressive supranuclear palsy or corticobasal degeneration was eventually confirmed at autopsy鈥攁t initial presentation and at 1-year follow-up and identifies features associated with underlying pathology.