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October 2024 - April 2016

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November 2021, Vol 6, No. 11, Pages 1232-1344

Original Investigation

Blood DNA Methylation and Incident Coronary Heart Disease: Evidence From the Strong Heart Study

Abstract Full Text
free access
JAMA Cardiol. 2021;6(11):1237-1246. doi:10.1001/jamacardio.2021.2704

This cohort study investigates the association of blood DNA methylation with incident coronary heart disease using a large number of methylation sites in a single model.

Genomic Autopsy of Sudden Deaths in Young Individuals

Abstract Full Text
free access
JAMA Cardiol. 2021;6(11):1247-1256. doi:10.1001/jamacardio.2021.2789

This cohort study assesses genotype and phenotype risk in a diverse cohort of individuals who died a sudden death and their families.

Association of Statin Treatment With Progression of Coronary Atherosclerotic Plaque Composition

Abstract Full Text
free access
JAMA Cardiol. 2021;6(11):1257-1266. doi:10.1001/jamacardio.2021.3055

This cohort study uses coronary computed tomography angiography to investigate whether statin therapy is associated with alterations in the volume or calcium density of 6 compositional atherosclerotic plaque types in patients with coronary artery disease.

Prevalence of Transthyretin Amyloid Cardiomyopathy in Heart Failure With Preserved Ejection Fraction

Abstract Full Text
free access has audio
JAMA Cardiol. 2021;6(11):1267-1274. doi:10.1001/jamacardio.2021.3070

This cohort study examined the prevalence of transthyretin amyloid cardiomyopathy among patients with heart failure, preserved ejection fraction, and ventricular wall thickening who did and did not undergo systematic screening.

Sex Differences in Procedural Outcomes Among Patients Undergoing Left Atrial Appendage Occlusion: Insights From the NCDR LAAO Registry

Abstract Full Text
free access
JAMA Cardiol. 2021;6(11):1275-1284. doi:10.1001/jamacardio.2021.3021

This cohort study uses data from the National Cardiovascular Data Registry LAAO Registry to evaluate the sex differences in the baseline characteristics of patients undergoing left atrial appendage occlusion implant and in the in-hospital outcomes after left atrial appendage occlusion implant.

Performance of a Convolutional Neural Network and Explainability Technique for 12-Lead Electrocardiogram Interpretation

Abstract Full Text
free access
JAMA Cardiol. 2021;6(11):1285-1295. doi:10.1001/jamacardio.2021.2746

This cross-sectional study assesses the ability of a convolutional neural network trained on available electrocardiogram data to interpret electrocardiogram results compared with clinical standards of care.

Extrapolating Long-term Event-Free and Overall Survival With Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction: An Exploratory Analysis of a Phase 3 Randomized Clinical Trial

Abstract Full Text
free access
JAMA Cardiol. 2021;6(11):1298-1305. doi:10.1001/jamacardio.2021.2632

This exploratory analysis of a randomized clinical trial extrapolates findings to estimate event-free and overall survival time with long-term dapagliflozin therapy in patients with heart failure and reduced ejection fraction.

Exercise Capacity in Young Adults Born Small for Gestational Age

Abstract Full Text
free access has multimedia
JAMA Cardiol. 2021;6(11):1308-1316. doi:10.1001/jamacardio.2021.2537

This cohort study assesses exercise capacity and baseline cardiac structure and function among young adults born with a birth weight below the 10th centile (small for gestational age).

Brief Report

Effect of Exercise Training on Ambulatory Blood Pressure Among Patients With Resistant Hypertension: A Randomized Clinical Trial

Abstract Full Text
free access
JAMA Cardiol. 2021;6(11):1317-1323. doi:10.1001/jamacardio.2021.2735

This randomized clinical trial evaluates whether an aerobic exercise training intervention reduces ambulatory blood pressure among patients with resistant hypertension.

Association of Atrial Fibrillation Burden With Health-Related Quality of Life After Atrial Fibrillation Ablation: Substudy of the Cryoballoon vs Contact-Force Atrial Fibrillation Ablation (CIRCA-DOSE) Randomized Clinical Trial

Abstract Full Text
free access
JAMA Cardiol. 2021;6(11):1324-1328. doi:10.1001/jamacardio.2021.3063

This post hoc analysis of a randomized clinical trial evaluates the association between change in atrial fibrillation burden and quality of life among patients with a low preablation atrial fibrillation burden.

Research Letter

Hospital Use for Myocardial Infarction and Stroke Among Medicare Beneficiaries From March to December 2020

Abstract Full Text
free access
JAMA Cardiol. 2021;6(11):1340-1342. doi:10.1001/jamacardio.2021.2729

This cross-sectional study compares 2020 weekly rates of hospital use for acute myocardial infarction and stroke with 2018 and 2019 weekly rates among Medicare fee-for-service beneficiaries in the US.

Viewpoint

Implications of Premature Coronary Artery Calcification in Primary and Secondary Prevention of Atherosclerotic Cardiovascular Disease

Abstract Full Text
JAMA Cardiol. 2021;6(11):1233-1234. doi:10.1001/jamacardio.2021.3393

This Viewpoint discusses the potential value of incidentally observed coronary artery calcification (CAC) in deciding to initiate early prevention, even in the absence of symptoms.

From the Heart

What We Talk About When We Talk About the Code

Abstract Full Text
JAMA Cardiol. 2021;6(11):1235-1236. doi:10.1001/jamacardio.2021.3199

This essay discusses experience with cardiac arrest and cardiopulmonary resuscitation in the personal vs clinical arena.

Invited Commentary

Leveraging Large Clinical Data Sets for Artificial Intelligence in Medicine

Abstract Full Text
JAMA Cardiol. 2021;6(11):1296-1297. doi:10.1001/jamacardio.2021.2878

Extrapolating Survival From Randomized Clinical Trial Data—Possibilities and Caution

Abstract Full Text
JAMA Cardiol. 2021;6(11):1305-1307. doi:10.1001/jamacardio.2021.2629
Review

Clinical Strategy for the Diagnosis and Treatment of Immune Checkpoint Inhibitor–Associated Myocarditis: A Narrative Review

Abstract Full Text
JAMA Cardiol. 2021;6(11):1329-1337. doi:10.1001/jamacardio.2021.2241

This narrative review provides an overview of the diagnostic and therapeutic approach for patients with suspected immune checkpoint inhibitor–associated myocarditis.

JAMA Cardiology Clinical Challenge

Worsening Cardiomyopathy Despite Biventricular Pacing

Abstract Full Text
JAMA Cardiol. 2021;6(11):1338-1339. doi:10.1001/jamacardio.2021.2755

A man in his early 70s with a history of permanent atrial fibrillation treated with atrioventricular junction ablation and biventricular pacemaker implantation was hospitalized with decompensated heart failure and acute kidney injury. His history was notable for nonischemic cardiomyopathy with ejection fraction of 40% and single-lung transplant for idiopathic pulmonary fibrosis. What would you do next?

Cardiovascular Images

A Woman in Her 60s With an Unusual Recurrent High Fever and Chills

Abstract Full Text
online only
JAMA Cardiol. 2021;6(11):e213362. doi:10.1001/jamacardio.2021.3362

This case report describes a patient with an aortic graft infection after thoracic endovascular aortic repair.

Comment & Response

Assessment of the Change of a Continuous Variable as a Function of its Initial Value

Abstract Full Text
JAMA Cardiol. 2021;6(11):1342. doi:10.1001/jamacardio.2021.3025

Assessment of the Change of a Continuous Variable as a Function of its Initial Value—Reply

Abstract Full Text
JAMA Cardiol. 2021;6(11):1342-1343. doi:10.1001/jamacardio.2021.3028

Reporting of Percutaneous Coronary Interventions Site-Specific Mortality

Abstract Full Text
JAMA Cardiol. 2021;6(11):1343. doi:10.1001/jamacardio.2021.2105

Reporting of Percutaneous Coronary Interventions Site-Specific Mortality—Reply

Abstract Full Text
JAMA Cardiol. 2021;6(11):1344. doi:10.1001/jamacardio.2021.2108
Correction

Change to Open Access Status

Abstract Full Text
free access
JAMA Cardiol. 2021;6(11):1344. doi:10.1001/jamacardio.2021.3756
JAMA Cardiology Masthead

JAMA Cardiology

Abstract Full Text
free access
JAMA Cardiol. 2021;6(11):1232. doi:10.1001/jamacardio.2020.4588
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