Ana Navas-Acien, MD, PhD; Arce Domingo-Relloso, MS; Pooja Subedi, MPH; et al.
free access
JAMA Cardiol. 2021;6(11):1237-1246. doi:10.1001/jamacardio.2021.2704
This cohort study investigates the association of blood DNA methylation with incident coronary heart disease using a large number of methylation sites in a single model.
Gregory Webster, MD, MPH; Megan J. Puckelwartz, PhD; Lorenzo L. Pesce, PhD; et al.
free access
JAMA Cardiol. 2021;6(11):1247-1256. doi:10.1001/jamacardio.2021.2789
This cohort study assesses genotype and phenotype risk in a diverse cohort of individuals who died a sudden death and their families.
Alexander R. van Rosendael, MD; Inge J. van den Hoogen, MD; Umberto Gianni, MD; et al.
free access
JAMA Cardiol. 2021;6(11):1257-1266. doi:10.1001/jamacardio.2021.3055
This cohort study uses coronary computed tomography angiography to investigate whether statin therapy is associated with alterations in the volume or calcium density of 6 compositional atherosclerotic plaque types in patients with coronary artery disease.
Omar F. AbouEzzeddine, MDCM, MS; Daniel R. Davies, MD; Christopher G. Scott, MS; et al.
free access
has audio
JAMA Cardiol. 2021;6(11):1267-1274. doi:10.1001/jamacardio.2021.3070
This cohort study examined the prevalence of transthyretin amyloid cardiomyopathy among patients with heart failure, preserved ejection fraction, and ventricular wall thickening who did and did not undergo systematic screening.
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Podcast:
Transthyretin Amyloid Cardiomyopathy in Patients With Heart Failure With Preserved Ejection Fraction
Douglas Darden, MD; Thao Duong, MD; Chengan Du, PhD; et al.
free access
JAMA Cardiol. 2021;6(11):1275-1284. doi:10.1001/jamacardio.2021.3021
This cohort study uses data from the National Cardiovascular Data Registry LAAO Registry to evaluate the sex differences in the baseline characteristics of patients undergoing left atrial appendage occlusion implant and in the in-hospital outcomes after left atrial appendage occlusion implant.
J. Weston Hughes, BA; Jeffrey E. Olgin, MD; Robert Avram, MD, MSc; et al.
free access
JAMA Cardiol. 2021;6(11):1285-1295. doi:10.1001/jamacardio.2021.2746
This cross-sectional study assesses the ability of a convolutional neural network trained on available electrocardiogram data to interpret electrocardiogram results compared with clinical standards of care.
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Invited Commentary
Leveraging Large Clinical Data Sets for Artificial Intelligence in Medicine
David Ouyang, MD; Christine M. Albert, MD, MPH
JAMA Cardiol
Kieran F. Docherty, MB, ChB; Pardeep S. Jhund, MBChB, MSc, PhD; Brian Claggett, PhD; et al.
free access
JAMA Cardiol. 2021;6(11):1298-1305. doi:10.1001/jamacardio.2021.2632
This exploratory analysis of a randomized clinical trial extrapolates findings to estimate event-free and overall survival time with long-term dapagliflozin therapy in patients with heart failure and reduced ejection fraction.
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Invited Commentary
Extrapolating Survival From Randomized Clinical Trial Data—Possibilities and Caution
Laine Elliott Thomas, PhD; Ann Marie Navar, MD; Michael J. Pencina, PhD
JAMA Cardiol
Fàtima Crispi, MD, PhD; Mérida Rodríguez-López, MD, PhD; Gabriel Bernardino, PhD; et al.
free access
has multimedia
JAMA Cardiol. 2021;6(11):1308-1316. doi:10.1001/jamacardio.2021.2537
This cohort study assesses exercise capacity and baseline cardiac structure and function among young adults born with a birth weight below the 10th centile (small for gestational age).
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Video:
Ventricular Shape Patterns in Young Adults Born Small for Gestational Age vs Control Patients