NEUROLOGY
Zuzana Nedelska, MD, MS; Christopher G. Schwarz, PhD; Timothy G. Lesnick, MS; et al.
This cohort study determines the trajectory of 尾-amyloid accumulation among patients with probable dementia with Lewy bodies and investigates the associations of 尾-amyloid accumulation with measures of clinical and cognitive decline over time in dementia with Lewy bodies.
JAMA Netw Open. 2019;2(12):e1916439. doi:10.1001/jamanetworkopen.2019.16439
CARDIOLOGY
Claire A. Lawson, PhD; Francesco Zaccardi, PhD; Gerry P. McCann, MD; et al.
This cohort study investigates changes in cause-specific outcomes and trends associated with type 2 diabetes among individuals with incident heart failure in the United Kingdom from 1998 to 2017.
JAMA Netw Open. 2019;2(12):e1916447. doi:10.1001/jamanetworkopen.2019.16447
EMERGENCY MEDICINE
Elizabeth M. Schoenfeld, MD, MS; Meng-Shiou Shieh, PhD; Penelope S. Pekow, PhD; et al.
This cohort study assesses the rate and timing of urologic procedures performed after an emergency department visit for renal colic and the factors associated with receipt of an intervention within 60 days.
JAMA Netw Open. 2019;2(12):e1916454. doi:10.1001/jamanetworkopen.2019.16454
EMERGENCY MEDICINE
Steven Horng, MD, MMSc; Joshua W. Joseph, MD, MS, MBE; Shelley Calder, DNP, RN; et al.
This cohort study determines whether a simple visual aid is associated with a reduction in duplicate ordering of tests and medications in an emergency department.
JAMA Netw Open. 2019;2(12):e1916499. doi:10.1001/jamanetworkopen.2019.16499
SURGERY
Alfred P. Yoon, MD; Tanvi Mahajani, MHSA; David W. Hutton, PhD; et al.
This economic evaluation compares the cost-effectiveness of finger replantation vs revision amputation after traumatic finger amputation.
JAMA Netw Open. 2019;2(12):e1916509. doi:10.1001/jamanetworkopen.2019.16509
SUBSTANCE USE AND ADDICTION
Thuy Nguyen, PhD; Barbara Andraka-Christou, JD, PhD; Kosali Simon, PhD; et al.
This cross-sectional study compares direct-to-physician commercial promotion of medications for opioid use disorder in rural vs urban county locations.
JAMA Netw Open. 2019;2(12):e1916520. doi:10.1001/jamanetworkopen.2019.16520
IMMUNOLOGY
David A. Zidar, MD, PhD; Sadeer G. Al-Kindi, MD; Yongmei Liu, MD, PhD; et al.
This cohort study assesses whether lymphopenia is associated with reduced survival among outpatients enrolled in the US National Health and Nutrition Examination Survey.
JAMA Netw Open. 2019;2(12):e1916526. doi:10.1001/jamanetworkopen.2019.16526
GLOBAL HEALTH
David J. Heller, MD, MPH; Anirudh Kumar, MD, MPH; Sandeep P. Kishore, MD, PhD; et al.
This systematic review and qualitative analysis examines the health system barriers to and facilitators of care for noncommunicable diseases by nonphysician health workers in low- and middle-income countries.
JAMA Netw Open. 2019;2(12):e1916545. doi:10.1001/jamanetworkopen.2019.16545
CARDIOLOGY
Haibin Li, PhD; Deqiang Zheng, PhD; Zhiwei Li, MS; et al.
This cohort study examines the association between depressive symptoms and incident cardiovascular disease among middle-aged and older Chinese adults.
JAMA Netw Open. 2019;2(12):e1916591. doi:10.1001/jamanetworkopen.2019.16591
CARDIOLOGY
Daniel N. Silverman, MD; Timothy B. Plante, MD, MHS; Margaret Infeld, MD, MS; et al.
This secondary analysis of the TOPCAT randomized clinical trial examines the association of 尾-blocker use with heart failure (HF) hospitalizations and cardiovascular disease (CVD) mortality, overall and in strata of patients with an ejection fraction (EF) of 50% or greater or less than 50%.
JAMA Netw Open. 2019;2(12):e1916598. doi:10.1001/jamanetworkopen.2019.16598
NEUROLOGY
Jennifer L. Dearborn-Tomazos, MD; Aozhou Wu, PhD; Lyn M. Steffen, PhD; et al.
This cohort study examines the association of dietary patterns in midlife with cognitive function in later life in US adults without dementia at baseline.
JAMA Netw Open. 2019;2(12):e1916641. doi:10.1001/jamanetworkopen.2019.16641
GERIATRICS
Ickpyo Hong, PhD, OTR; James S. Goodwin, MD; Timothy A. Reistetter, PhD, OTR; et al.
This cohort study examines the difference in improvement of functional status among patients with stroke who received postacute care in inpatient rehabilitation vs skilled nursing facilities.
JAMA Netw Open. 2019;2(12):e1916646. doi:10.1001/jamanetworkopen.2019.16646
PUBLIC HEALTH
Samir Soneji, PhD; Hiram Beltrán-Sánchez, PhD
This cohort study analyzes the association between participation in the Women, Infants, and Children (WIC) program and birth outcomes among low-income pregnant women in the United States by gestational age at birth and maternal race/ethnicity.
JAMA Netw Open. 2019;2(12):e1916722. doi:10.1001/jamanetworkopen.2019.16722
PUBLIC HEALTH
Holli A. Loomans-Kropp, PhD, MPH; Paul Pinsky, PhD; Yin Cao, ScD, MPH; et al.
This cohort study uses data from the Prostate, Lung, Colorectal, and Ovarian Cancer Screen Trial to examine the associations among regular aspirin use, obesity, and all-cause and cancer mortality among older adults.
JAMA Netw Open. 2019;2(12):e1916729. doi:10.1001/jamanetworkopen.2019.16729
HEALTH POLICY
Gabriel J. Escobar, MD; Colleen Plimier, MPH; John D. Greene, MA; et al.
This cohort study examines rehospitalization factors, hospitalization and mortality, discharge disposition, and the changes in these variables over time among all adult patients in the Kaiser Permanente Northern California health system.
JAMA Netw Open. 2019;2(12):e1916769. doi:10.1001/jamanetworkopen.2019.16769
NUTRITION, OBESITY, AND EXERCISE
Nudrat Noor, PhD; Andres Cardenas, PhD, MPH; Sheryl L. Rifas-Shiman, MPH; et al.
This cohort study investigates the associations between periconception paternal body mass index (BMI) and DNA methylation patterns in offspring.
JAMA Netw Open. 2019;2(12):e1916777. doi:10.1001/jamanetworkopen.2019.16777
PUBLIC HEALTH
Olufunmilayo H. Obisesan, MD, MPH; Mohammadhassan Mirbolouk, MD; Albert D. Osei, MD, MPH; et al.
This cross-sectional study examines the association between electronic cigarette (e-cigarette) use and depression in a nationally representative sample of the adult population in the United States.
JAMA Netw Open. 2019;2(12):e1916800. doi:10.1001/jamanetworkopen.2019.16800
COMPLEMENTARY AND ALTERNATIVE MEDICINE
M. Kay Garcia, DrPH; Zhiqiang Meng, MD; David I. Rosenthal, MD; et al.
This randomized clinical trial examines the efficacy of true or sham acupuncture vs standard care in the treatment of radiation-induced xerostomia among patients in the United States and China.
JAMA Netw Open. 2019;2(12):e1916910. doi:10.1001/jamanetworkopen.2019.16910
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Invited Commentary
Acupuncture鈥擜 Question of Culture
Matthias Karst, MD, PhD; Changwei Li, MD, PhD, MPH, LAc
JAMA Netw Open
NEPHROLOGY
Victor J. Lei, PharmD; ThaiBinh Luong, PhD; Eric Shan; et al.
This prognostic study evaluates the addition of preoperative and intraoperative data to prehospitalization data to identify patients at risk for postoperative acute kidney injury after undergoing major noncardiac surgery.
JAMA Netw Open. 2019;2(12):e1916921. doi:10.1001/jamanetworkopen.2019.16921
ONCOLOGY
Makoto Ohno, MD, PhD; Juntaro Matsuzaki, MD, PhD; Junpei Kawauchi, BS; et al.
This diagnostic study establishes and assesses models to detect diffuse glioma and to differentiate glioblastoma, primary central nervous system lymphoma, and metastatic brain tumors.
JAMA Netw Open. 2019;2(12):e1916953. doi:10.1001/jamanetworkopen.2019.16953
IMAGING
Nigel D鈥橲ouza, MBBS; Annabel Shaw, MBBS; Amy Lord, MBBS; et al.
This prognostic study assesses whether preoperative computed tomographic findings can be used for sigmoid colon cancer prognosis.
JAMA Netw Open. 2019;2(12):e1916987. doi:10.1001/jamanetworkopen.2019.16987
PUBLIC HEALTH
Janet Audrain-McGovern, PhD; Daniel Rodriguez, PhD; Emily Alexander, BA; et al.
This cohort study examines the association of blunt use with cigar use among US adolescents.
JAMA Netw Open. 2019;2(12):e1917001. doi:10.1001/jamanetworkopen.2019.17001
PUBLIC HEALTH
Maryam Guiahi, MD, MSc; Patricia E. Helbin; Stephanie B. Teal, MD, MPH; et al.
This population-based survey study examines patient views on religious institutional care, specifically whether they consider religious affiliation when selecting a health care facility and whether they believe that their personal choices about their health should take priority over a facility鈥檚 religious values.
JAMA Netw Open. 2019;2(12):e1917008. doi:10.1001/jamanetworkopen.2019.17008
HEALTH POLICY
Laura A. Schoenherr, MD; Kara E. Bischoff, MD; Angela K. Marks, MSEd; et al.
This cohort study characterizes current practice and trends among patients cared for and outcomes achieved by inpatient specialty palliative care services in the United States.
JAMA Netw Open. 2019;2(12):e1917043. doi:10.1001/jamanetworkopen.2019.17043
RHEUMATOLOGY
Mark Tatangelo, BA; George Tomlinson, PhD; J. Michael Paterson, MSc; et al.
This cohort study evaluates the associations of patient, prescriber, and geographic region with differences in time to first prescription of biologic disease-modifying antirheumatic drug among older adults with rheumatoid arthritis and identical health insurance coverage in Ontario, Canada.
JAMA Netw Open. 2019;2(12):e1917053. doi:10.1001/jamanetworkopen.2019.17053
ONCOLOGY
Greg J. Haro, MD; Bonnie Sheu, MD; Nancy R. Cook, ScD; et al.
This cohort study examines whether incorporation of a molecular prognostic classifier into conventional TNM staging for non鈥搒mall cell lung cancer improves estimation of disease-free survival.
JAMA Netw Open. 2019;2(12):e1917062. doi:10.1001/jamanetworkopen.2019.17062
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Invited Commentary
Biomarker-Driven Staging鈥擜re We There Yet?
Siddhartha Devarakonda, MD; Ramaswamy Govindan, MD
JAMA Netw Open
HEALTH INFORMATICS
Lorenzo Moja, MD, PhD; Hernan Polo Friz, MD; Matteo Capobussi, MD; et al.
This randomized clinical trial assesses the effectiveness of a computerized decision support system that preappraises evidence and provides health professionals with actionable, patient-specific recommendations at the point of care.
JAMA Netw Open. 2019;2(12):e1917094. doi:10.1001/jamanetworkopen.2019.17094
NEUROLOGY
Jorge J. Llibre-Guerra, MD, MSc; Yan Li, PhD; Suzanne E. Schindler, MD, PhD; et al.
This cohort study of participants with dominantly inherited Alzheimer disease examines the rates of change in cerebrospinal fluid levels of total tau (tTau) and phosphorylated tau 181 (pTau181) across the disease course and how the rates of change are associated with brain atrophy.
JAMA Netw Open. 2019;2(12):e1917126. doi:10.1001/jamanetworkopen.2019.17126
INFECTIOUS DISEASES
Jason J. Ong, PhD, MBBS; Rachel C. Baggaley, MSc, MBBS; Teodora E. Wi, MD; et al.
This systematic review and meta-analysis estimates the prevalence of sexually transmitted infections at initiation of HIV preexposure prophylaxis (PrEP) and the incidence of sexually transmitted infections during use of HIV PrEP.
JAMA Netw Open. 2019;2(12):e1917134. doi:10.1001/jamanetworkopen.2019.17134
DIABETES AND ENDOCRINOLOGY
Guneet K. Jasuja, PhD; Omid Ameli, MD, MPH; Joel I. Reisman, AB; et al.
This cohort study analyzes the association between testosterone and opioid use and improved health outcomes among male US military veterans with opioid-induced androgen deficiency.
JAMA Netw Open. 2019;2(12):e1917141. doi:10.1001/jamanetworkopen.2019.17141
HEALTH INFORMATICS
Kyan C. Safavi, MD, MBA; Taghi Khaniyev, PhD; Martin Copenhaver, PhD; et al.
This prognostic study develops and validates the performance of a neural network machine learning model compared with a model based on median length of stay for predicting which patients are likely to be discharged within 24 hours from inpatient surgical care and their barriers to discharge.
JAMA Netw Open. 2019;2(12):e1917221. doi:10.1001/jamanetworkopen.2019.17221
PHARMACY AND CLINICAL PHARMACOLOGY
Andrew Stokes, PhD; Kaitlyn M. Berry, MPH; Katherine Hempstead, PhD; et al.
This cross-sectional study uses data from the National Health and Nutrition Examination Study to evaluate trends in prescription opioid use and nonopioid analgesic use from 1999 to 2016 among US adults with functional limitations attributable to musculoskeletal conditions.
JAMA Netw Open. 2019;2(12):e1917228. doi:10.1001/jamanetworkopen.2019.17228
EMERGENCY MEDICINE
Ambarish M. Athavale, MBBS, MD; Chih-Yuan Fu, MD; Faran Bokhari, MD; et al.
This cross-sectional study determines the incidence of and risk factors associated with severe acute kidney injury (AKI) and AKI requiring dialysis after gunshot wounds and the association of severe AKI and AKI requiring dialysis with mortality among civilians in the United States.
JAMA Netw Open. 2019;2(12):e1917254. doi:10.1001/jamanetworkopen.2019.17254
GERIATRICS
Hideaki Suzuki, MD, PhD; Ashwin V. Venkataraman, MD; Wenjia Bai, DPhil; et al.
This cross-sectional study examines the associations of aging and modifiable risk factors for dementia with volume differences in brain regions known to be associated with Alzheimer disease and whether these volume differences are associated with cognitive performance.
JAMA Netw Open. 2019;2(12):e1917257. doi:10.1001/jamanetworkopen.2019.17257
ORTHOPEDICS
Nitin B. Jain, MD, MSPH; Emily Peterson, BS, MS; Gregory D. Ayers, MS; et al.
This cross-sectional study estimates time trends and geographical variations in rates of arthroscopic surgery among US states and investigates whether rates of arthroscopy are associated with geographic density of orthopedists.
JAMA Netw Open. 2019;2(12):e1917315. doi:10.1001/jamanetworkopen.2019.17315
CRITICAL CARE MEDICINE
Jacqueline M. Kruser, MD, MS; David A. Aaby, MS; David G. Stevenson, PhD; et al.
This cohort study describes the structures, processes, and variability of end-of-life care delivered in intensive care units in the United States.
JAMA Netw Open. 2019;2(12):e1917344. doi:10.1001/jamanetworkopen.2019.17344
NEUROLOGY
Stephanie L. Garrett, MD; Darius McDaniel, MSPH; Malik Obideen, MD; et al.
This case-control study compares cerebrospinal fluid (CSF) amyloid and tau biomarkers for Alzheimer disease in African American and white individuals with normal cognition and with mild cognitive impairment.
JAMA Netw Open. 2019;2(12):e1917363. doi:10.1001/jamanetworkopen.2019.17363
NUTRITION, OBESITY, AND EXERCISE
Guochong Jia, MPH; Xiao-Ou Shu, PhD; Ying Liu, MPH; et al.
This population-based cohort study investigates the association of adult weight gain with major health outcomes in middle-aged Chinese persons who had low body weight in early adulthood.
JAMA Netw Open. 2019;2(12):e1917371. doi:10.1001/jamanetworkopen.2019.17371
HEALTH POLICY
Cheryl D. Stults, PhD; Jiang Li, PhD; Dominick L. Frosch, PhD; et al.
This quality improvement study examines the accuracy and user experience of a cost estimator tool delivered via an online patient portal and informed by real-time data from third-party payers.
JAMA Netw Open. 2019;2(12):e1917445. doi:10.1001/jamanetworkopen.2019.17445
PSYCHIATRY
Jeffrey Allen Smith, PhD; Michael Doidge, PhD; Ryan Hanoa; et al.
This cross-sectional study consolidates data on suicides among active-duty personnel in the US Army from 1819 to 2017 and identifies historical trends to separate them from more acute causal factors.
JAMA Netw Open. 2019;2(12):e1917448. doi:10.1001/jamanetworkopen.2019.17448
STATISTICS AND RESEARCH METHODS
Samuel M. Rubinstein, MD; Elizabeth A. Sigworth, BA; Shervin Etemad, BA; et al.
This systematic review and meta-analysis examines the expression of uncertainty in abstracts of published oncology randomized clinical trials.
JAMA Netw Open. 2019;2(12):e1917530. doi:10.1001/jamanetworkopen.2019.17530
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Invited Commentary
Improved Reporting in Abstracts When Uncertainty Is Inevitable
Susan Halabi, PhD; Simon Day, PhD
JAMA Netw Open
PSYCHIATRY
Xiaoyu Li, ScD; Jun Aida, PhD; Hiroyuki Hikichi, PhD; et al.
This cohort study of community-dwelling survivors of the 2011 Great East Japan Earthquake and Tsunami assesses whether postdisaster depression and posttraumatic stress disorder are associated with mortality.
JAMA Netw Open. 2019;2(12):e1917550. doi:10.1001/jamanetworkopen.2019.17550
HEALTH POLICY
Matt P. Malcolm, PhD, OTR/L; Addie Middleton, PhD, DPT; Allen Haas, MS; et al.
This cohort study examines the differences between 2 Centers for Medicare & Medicaid Services measures for 30-day rehospitalization after discharge from postacute inpatient rehabilitation.
JAMA Netw Open. 2019;2(12):e1917559. doi:10.1001/jamanetworkopen.2019.17559
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Invited Commentary
In Pursuit of Meaningful Performance Measures for Postacute Care
Andrea Gilmore-Bykovskyi, PhD, RN; Christopher J. Crnich, MD, PhD; Amy J. H. Kind, MD, PhD
JAMA Netw Open
PSYCHIATRY
Sidra Goldman-Mellor, PhD; Mark Olfson, MD, MPH; Cristina Lidon-Moyano, PhD; et al.
This cohort study examines the association of suicide and other mortality risk within 1 year of emergency department presentation among patients presenting with deliberate self-harm, suicidal ideation, or any other chief concern.
JAMA Netw Open. 2019;2(12):e1917571. doi:10.1001/jamanetworkopen.2019.17571
SURGERY
Kristina H. Lewis, MD, MPH, SM; David E. Arterburn, MD, MPH; Katherine Callaway, MPH; et al.
This cohort study compares the risk of operative and nonoperative interventions up to 4 years after Roux-en-Y gastric bypass vs vertical sleeve gastrectomy in patient groups matched on US region, year of surgery, body mass index category, and type 2 diabetes status.
JAMA Netw Open. 2019;2(12):e1917603. doi:10.1001/jamanetworkopen.2019.17603
NEUROLOGY
John Breck, DO; Adam Bohr, PhD; Sourav Poddar, MD; et al.
This cohort study examines the incidence of sport-related and non鈥搒port-related concussions among US undergraduate college students and varsity athletes stratified by sex and cause of concussion.
JAMA Netw Open. 2019;2(12):e1917626. doi:10.1001/jamanetworkopen.2019.17626
ENVIRONMENTAL HEALTH
Emily C. Moody, MD, MHS, MS; Alejandra Cantoral, PhD; Marcela Tamayo-Ortiz, ScD; et al.
This birth cohort study examines the association between prenatal and perinatal exposures to fine particulate matter (diameter <2.5 渭m) and changes in hemoglobin A1c levels in children aged 4 to 6 years.
JAMA Netw Open. 2019;2(12):e1917643. doi:10.1001/jamanetworkopen.2019.17643
PUBLIC HEALTH
Kathleen M. Powis, MD, MBA, MPH; Yanling Huo, MS; Paige L. Williams, PhD; et al.
This cohort study compares antiretroviral prescribing practices over time among pregnant women living with HIV with US Department of Health and Human Services treatment guidelines.
JAMA Netw Open. 2019;2(12):e1917669. doi:10.1001/jamanetworkopen.2019.17669
HEALTH INFORMATICS
Stephen M. Downs, MD, MS; Nerissa S. Bauer, MD, MPH; Chandan Saha, PhD; et al.
This randomized clinical trial examines whether computer-automated screening and clinical decision support can improve autism spectrum disorder screening rates in a pediatric primary care practice.
JAMA Netw Open. 2019;2(12):e1917676. doi:10.1001/jamanetworkopen.2019.17676
PUBLIC HEALTH
Pang Yao, PhD; Derrick Bennett, PhD; Marion Mafham, MD; et al.
This systematic review and meta-analysis assesses the risk of fracture associated with differences in concentrations of 25-hydroxyvitamin D (25[OH]D) in observational studies and the effects of supplementation with vitamin D alone or in combination with calcium on fracture in randomized clinical trials.
has audio
JAMA Netw Open. 2019;2(12):e1917789. doi:10.1001/jamanetworkopen.2019.17789
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Podcast:
Vitamin D and Calcium for Fracture Prevention; Physician Self-reported Knowledge and Use of Maryland鈥檚 Extreme Risk Protection Order Law
ENVIRONMENTAL HEALTH
Bo-Yi Yang, PhD; Xiao-Wen Zeng, PhD; Iana Markevych, PhD; et al.
This cross-sectional study evaluates the association between greenness surrounding schools or kindergartens and symptoms of attention-deficit/hyperactivity disorder among Chinese children.
JAMA Netw Open. 2019;2(12):e1917862. doi:10.1001/jamanetworkopen.2019.17862
CARDIOLOGY
Shiwani Mahajan, MBBS; Javier Valero-Elizondo, MD, MPH; Rohan Khera, MD; et al.
This cross-sectional study evaluates the prevalence and characteristics of US adults who are unaware of the symptoms of and appropriate response to myocardial infarction.
JAMA Netw Open. 2019;2(12):e1917885. doi:10.1001/jamanetworkopen.2019.17885
EMERGENCY MEDICINE
Jacqueline Grupp-Phelan, MD, MPH; Jack Stevens, PhD; Stephanie Boyd, PhD; et al.
This randomized clinical trial examines whether a motivational interviewing鈥揵ased intervention increases linkage of adolescents to outpatient mental health services and reduces depression symptoms and suicidal ideation in adolescents seeking emergency care for non鈥搈ental health鈥搑elated concerns.
JAMA Netw Open. 2019;2(12):e1917941. doi:10.1001/jamanetworkopen.2019.17941
PUBLIC HEALTH
Shaneda Warren Andersen, PhD; William J. Blot, PhD; Loren Lipworth, PhD; et al.
This cohort study examines the associations of colorectal cancer screening and modalities with colorectal cancer incidence and mortality by race and socioeconomic status among southern US adults.
JAMA Netw Open. 2019;2(12):e1917995. doi:10.1001/jamanetworkopen.2019.17995
MEDICAL JOURNALS AND PUBLISHING
Justin S. Brandt, MD; Ola Hadaya, MD; Meike Schuster, DO; et al.
This cross-sectional bibliometric analysis identifies top-cited articles on obstetrics and gynecology topics and compares top-cited articles published in obstetrics and gynecology specialty journals with those published in general medical journals.
JAMA Netw Open. 2019;2(12):e1918007. doi:10.1001/jamanetworkopen.2019.18007
MEDICAL EDUCATION
John E. Brush Jr, MD; Mark Lee, BSc; Jonathan Sherbino, MD, MEd; et al.
This randomized clinical trial evaluates whether medical students can be taught to make more accurate bayesian revisions of diagnostic probabilities using learning by concept or learning by example.
has multimedia
JAMA Netw Open. 2019;2(12):e1918023. doi:10.1001/jamanetworkopen.2019.18023
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Invited Commentary
The Pursuit of Diagnostic Excellence
Robert M. Centor, MD; Rabih Geha, MD; Reza Manesh, MD
JAMA Netw Open
PUBLIC HEALTH
Shannon Frattaroli, PhD, MPH; Katherine Hoops, MD, MPH; Nathan A. Irvin, MD; et al.
This survey study assesses Maryland physicians鈥� knowledge, past use, and likely future use of extreme risk protection orders, barriers to their use, and strategies to address those barriers.
has audio
JAMA Netw Open. 2019;2(12):e1918037. doi:10.1001/jamanetworkopen.2019.18037
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Podcast:
Vitamin D and Calcium for Fracture Prevention; Physician Self-reported Knowledge and Use of Maryland鈥檚 Extreme Risk Protection Order Law
ALLERGY
Matthew Greenhawt, MD, MBA, MSc; Marcus Shaker, MD, MSc
This economic evaluation identifies scenarios in which the current US guidelines for early introduction of peanut to infants would be cost-effective.
JAMA Netw Open. 2019;2(12):e1918041. doi:10.1001/jamanetworkopen.2019.18041
PEDIATRICS
Iná S. Santos, PhD; Bianca Del-Ponte, PhD; Luciana Tovo-Rodrigues, PhD; et al.
This randomized clinical trial examines the effect of parental counseling on bedtime routines and behaviors on infants鈥� sleep habits from ages 3 months to 2 years.
JAMA Netw Open. 2019;2(12):e1918062. doi:10.1001/jamanetworkopen.2019.18062
ONCOLOGY
Nan Bi, MD, PhD; Jun Liang, MD; Zongmei Zhou, MD; et al.
This phase 2 randomized clinical trial evaluates the effect of combined selective cyclooxygenase 2 (COX-2) inhibition with standard concurrent chemoradiation therapy vs concurrent chemoradiation alone on survival among patients with unresectable stage III non鈥搒mall cell lung cancer (NSCLC).
JAMA Netw Open. 2019;2(12):e1918070. doi:10.1001/jamanetworkopen.2019.18070
GENETICS AND GENOMICS
Rong Na, MD, PhD; Craig Labbate, MD; Hongjie Yu, PhD; et al.
This cohort study examines the association between a single-nucleotide polymorphism (SNP)鈥揵ased genetic risk score and patient age at prostate cancer diagnosis and compares the performance of the genetic risk score with that of family history in prostate cancer risk stratification.
JAMA Netw Open. 2019;2(12):e1918145. doi:10.1001/jamanetworkopen.2019.18145
NEPHROLOGY
Katherine R. Tuttle, MD; Radica Z. Alicic, MD; O. Kenrik Duru, MD; et al.
This cohort study examines the clinical features of, prevalence of, major risk factors for, and care for chronic kidney disease among adults and children treated in 2 large US health care systems.
JAMA Netw Open. 2019;2(12):e1918169. doi:10.1001/jamanetworkopen.2019.18169
NEUROLOGY
Russell Rosenberg, PhD; Patricia Murphy, PhD; Gary Zammit, PhD; et al.
This randomized clinical trial examines the effectiveness of treatment with lemborexant therapy compared with placebo and with zolpidem tartrate extended release therapy in adults 55 years and older with insomnia disorder.
JAMA Netw Open. 2019;2(12):e1918254. doi:10.1001/jamanetworkopen.2019.18254
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Invited Commentary
Pharmacotherapy for Insomnia Disorder in Older Adults
Michael A. Grandner, PhD, MTR; Michael L. Perlis, PhD
JAMA Netw Open
PEDIATRICS
Bror M. Ranum, CandPsych; Lars Wichstrøm, PhD; Ståle Pallesen, PhD; et al.
This population-based cohort study examines whether sleep duration is associated with the development of emotional and behavioral problems in school-aged children in Norway.
JAMA Netw Open. 2019;2(12):e1918281. doi:10.1001/jamanetworkopen.2019.18281
HEALTH INFORMATICS
Tracy A. Lieu, MD, MPH; Andrea Altschuler, PhD; Jonathan Z. Weiner, MD; et al.
This qualitative study conducted in a large group practice examines primary care physicians鈥� experiences managing their electronic message inboxes and describes the management strategies developed by individual physicians and practice groups.
JAMA Netw Open. 2019;2(12):e1918287. doi:10.1001/jamanetworkopen.2019.18287
PEDIATRICS
David M. Rubin, MD, MSCE; Chén C. Kenyon, MD, MSHP; Douglas Strane, MPH; et al.
This quality improvement study estimates the association of a targeted population health management intervention for children eligible for Medicaid with changes in monthly hospital admissions and bed-days.
JAMA Netw Open. 2019;2(12):e1918306. doi:10.1001/jamanetworkopen.2019.18306
INFECTIOUS DISEASES
Robin L. P. Jump, MD, PhD; Brigid M. Wilson, PhD; Daniel Baechle, MS; et al.
This cohort study investigates risk factors and mortality rates associated with specific invasive group B Streptococcus infectious syndromes among patients of the Veterans Affairs health care system.
JAMA Netw Open. 2019;2(12):e1918324. doi:10.1001/jamanetworkopen.2019.18324
SUBSTANCE USE AND ADDICTION
Sunil Agarwal, MD; John D. Bryan, MPP; Hsou Mei Hu, PhD, MBA, MHS; et al.
This interrupted time series analysis and cross-sectional study investigates the association of opioid prescribing duration limits with postoperative opioid prescribing in Massachusetts and Connecticut.
JAMA Netw Open. 2019;2(12):e1918361. doi:10.1001/jamanetworkopen.2019.18361
CARDIOLOGY
Scott Martin Vouri, PharmD, PhD; Xinyi Jiang, MS; Todd M. Manini, PhD; et al.
This cohort study used prescription sequence symmetry analysis to assess the magnitude and characteristics of the prescribing cascade of treating dihydropyridine calcium channel blocker鈥搃nduced lower-extremity edema with loop diuretics.
JAMA Netw Open. 2019;2(12):e1918425. doi:10.1001/jamanetworkopen.2019.18425
HEALTH POLICY
David J. Meyers, MPH; Cyrus M. Kosar, MA; Momotazur Rahman, PhD; et al.
This cohort study determines the association of bundled payments for joint replacement surgical procedures with the use of postacute care services among patients enrolled in Medicare Advantage.
JAMA Netw Open. 2019;2(12):e1918535. doi:10.1001/jamanetworkopen.2019.18535