PEDIATRICS
Laura J. Faherty, MD, MPH, MS; Ashley M. Kranz, PhD; Joshua Russell-Fritch, MS; et al.
This cross-sectional study examines the association of state-level punitive or reporting policies related to substance use during pregnancy with rates of neonatal abstinence syndrome.
JAMA Netw Open. 2019;2(11):e1914078. doi:10.1001/jamanetworkopen.2019.14078
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Invited Commentary
It’s Time to Support, Rather Than Punish, Pregnant Women With Substance Use Disorder
Daisy Goodman, DNP, MPH, CNM, CARN-AP; Bonny Whalen, MD; Lucy C. Hodder, Esq
JAMA Netw Open
PSYCHIATRY
Winston Chung, MD, MS; Sheng-Fang Jiang, MS; Diana Paksarian, MPH, PhD; et al.
This cohort study examines trends, including associated demographic characteristics, psychiatric diagnoses, and negative outcomes, in the prevalence and incidence of attention-deficit/hyperactivity disorder (ADHD) diagnosis among 7 racial/ethnic groups in the United States during a 10-year period.
JAMA Netw Open. 2019;2(11):e1914344. doi:10.1001/jamanetworkopen.2019.14344
DIABETES AND ENDOCRINOLOGY
A. Mark Fendrick, MD; Jason D. Buxbaum, MHSA; Yuexin Tang, PhD; et al.
This matched cohort study evaluates the association between switching from a non–high deductible health plan to a high-deductible health plan and discontinuation of antihyperglycemic medication among adults with type 2 diabetes.
JAMA Netw Open. 2019;2(11):e1914372. doi:10.1001/jamanetworkopen.2019.14372
INFECTIOUS DISEASES
Ayesha B. M. Kharsany, PhD; Cherie Cawood, MBA; Lara Lewis, MSc; et al.
This community-based cohort study examines trends in coverage of HIV prevention and treatment programs and HIV incidence among adults in the hyperendemic area of KwaZulu-Natal, South Africa.
JAMA Netw Open. 2019;2(11):e1914378. doi:10.1001/jamanetworkopen.2019.14378
HEALTH POLICY
William S. Yancy Jr, MD, MHSc; Pamela A. Shaw, PhD; Catherine Reale, BS; et al.
This randomized clinical trial assesses an escalating lottery-based incentive tied to daily self-weighing for weight loss maintenance among adults in an online weight management program.
JAMA Netw Open. 2019;2(11):e1914393. doi:10.1001/jamanetworkopen.2019.14393
PSYCHIATRY
Henriette Thisted Horsdal, MSc, PhD; Esben Agerbo, DrMedSc; John Joseph McGrath, PhD; et al.
This Danish population-based cohort study uses national registry data to evaluate the association of exposure to nitrogen dioxide in childhood and genetic liability for schizophrenia with the risk of developing schizophrenia.
JAMA Netw Open. 2019;2(11):e1914401. doi:10.1001/jamanetworkopen.2019.14401
SURGERY
Aviva S. Mattingly, BA; Benjamin J. Lerman, MD, MS; Rita Popat, PhD; et al.
This cohort study evaluates whether sex is associated with postoperative mortality among patients with heart failure who underwent elective noncardiac operations.
JAMA Netw Open. 2019;2(11):e1914420. doi:10.1001/jamanetworkopen.2019.14420
PEDIATRICS
Deepa L. Sekhar, MD, MSc; Krista L. Pattison, MS; Alexandra Confair, BS; et al.
This trial protocol describes a randomized clinical trial that will compare the effectiveness of universal school-based screening for adolescent major depressive disorder vs the existing process of targeted screening based on observable behavior.
JAMA Netw Open. 2019;2(11):e1914427. doi:10.1001/jamanetworkopen.2019.14427
HEALTH POLICY
Deepshikha Charan Ashana, MD, MBA; Xiaoxue Chen, MPH; Abiy Agiro, PhD; et al.
This cohort study examines the association between billed advance care planning encounters and subsequent health care utilization among seriously ill patients near the end of life.
JAMA Netw Open. 2019;2(11):e1914471. doi:10.1001/jamanetworkopen.2019.14471
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Invited Commentary
Placing Value on End-of-Life Care—Is It Time for a New Taxonomy?
May Hua, MD, MS; Hannah Wunsch, MD, MSc
JAMA Netw Open
ONCOLOGY
Andrea Covelli, MD, PhD; Marcia Facey, PhD; Erin Kennedy, MD, PhD; et al.
This qualitative study uses interviews with 22 Canadian clinicians to examine the perceived barriers to discussing fertility and fertility preservation with young women with cancer.
JAMA Netw Open. 2019;2(11):e1914511. doi:10.1001/jamanetworkopen.2019.14511
PEDIATRICS
Kenneth A. Dodge, PhD; W. Benjamin Goodman, PhD; Yu Bai, PhD; et al.
This randomized clinical trial examines the effects of a community agency–administered postnatal nurse home visitation program on child protective services investigations for maltreatment and other maternal and child health-related outcomes.
JAMA Netw Open. 2019;2(11):e1914522. doi:10.1001/jamanetworkopen.2019.14522
HEALTH POLICY
Wendy Yi Xu, PhD; Chi Song, PhD; Yiting Li, PhD; et al.
This cross-sectional study evaluates the cost-sharing payments for out-of-network care for insurance plan enrollees with mental health conditions, alcohol use disorders, or drug use disorders compared with those with congestive heart failure or diabetes.
JAMA Netw Open. 2019;2(11):e1914554. doi:10.1001/jamanetworkopen.2019.14554
PEDIATRICS
Eduardo Villamor-Martinez, MSc, MA; María Álvarez-Fuente, MD, PhD; Amro M. T. Ghazi, MD; et al.
This systematic review, meta-analysis, and metaregression of clinical studies explores the association between chorioamnionitis and bronchopulmonary dysplasia in preterm infants.
JAMA Netw Open. 2019;2(11):e1914611. doi:10.1001/jamanetworkopen.2019.14611
GASTROENTEROLOGY AND HEPATOLOGY
Naofumi Tomita, MS; Behnaz Abdollahi, PhD; Jason Wei; et al.
This diagnostic study describes a novel attention-based deep neural network framework for classifying microscopy images to identify Barrett esophagus and esophageal adenocarcinoma.
JAMA Netw Open. 2019;2(11):e1914645. doi:10.1001/jamanetworkopen.2019.14645
HEALTH INFORMATICS
Abeed Sarker, PhD; Graciela Gonzalez-Hernandez, PhD; Yucheng Ruan, BEng; et al.
This cross-sectional study develops and validates a machine learning method for collecting and classifying data from opioid-related postings on a social media platform.
JAMA Netw Open. 2019;2(11):e1914672. doi:10.1001/jamanetworkopen.2019.14672
ONCOLOGY
Kerri Beckmann, PhD; Danielle Crawley, PhD; Tobias Nordström, PhD; et al.
This cohort study examines the association between antidiabetic medication and prostate-specific antigen (PSA) levels, frequency of PSA testing and biopsy, and detection of prostate cancer at biopsy among Swedish men with diabetes.
JAMA Netw Open. 2019;2(11):e1914689. doi:10.1001/jamanetworkopen.2019.14689
HEALTH POLICY
Hyunjee Kim, PhD; Thomas H. A. Meath, MPH; Konrad Dobbertin, MPH; et al.
This cohort study examines changes in health care spending, use, and quality of care after the implementation of Medicare’s first mandatory bundled payment system at participating hospitals and among dual-eligible patients.
JAMA Netw Open. 2019;2(11):e1914696. doi:10.1001/jamanetworkopen.2019.14696
PUBLIC HEALTH
Ashley J. Vargas, PhD, MPH, RDN; Sheri D. Schully, PhD; Jennifer Villani, PhD, MPH; et al.
This cross-sectional study characterizes National Institutes of Health (NIH) support for primary and secondary prevention research in humans and related methods research of the leading risk factors or causes of death or disability as outcomes or exposures.
JAMA Netw Open. 2019;2(11):e1914718. doi:10.1001/jamanetworkopen.2019.14718
OBSTETRICS AND GYNECOLOGY
Rachel L. Winer, PhD, MPH; John Lin, BA; Jasmin A. Tiro, PhD; et al.
This randomized clinical trial evaluates the effectiveness of mailed self-test kits for human papillomavirus (HPV) vs usual care for detection and treatment of cervical precancers and uptake of cervical cancer screening.
JAMA Netw Open. 2019;2(11):e1914729. doi:10.1001/jamanetworkopen.2019.14729
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Invited Commentary
Home Screening for Human Papillomavirus Falls Short in Initial Application, Remains Promising
Chailee Faythe Moss, MD; Betty Chou, MD; Jenell S. Coleman, MD, MPH
JAMA Netw Open
RHEUMATOLOGY
Adrienne Strait, BA; Francine Castillo, BS; Sonam Choden, BS; et al.
This systematic review examines the representation in rheumatoid arthritis randomized clinical trials of racial/ethnic minority groups compared with the representation of these populations in the United States and the representation of women and elderly people with the prevalence of rheumatoid arthritis among these groups nationally.
JAMA Netw Open. 2019;2(11):e1914745. doi:10.1001/jamanetworkopen.2019.14745
ORTHOPEDICS
Daniel Wenger, MD, PhD; Henrik Düppe, MD, PhD; Jan-Åke Nilsson, BS; et al.
This nested case-control study investigates the incidence and risk factors of late-diagnosed hip dislocation among Swedish children undergoing clinical screening for hip instability as neonates.
JAMA Netw Open. 2019;2(11):e1914779. doi:10.1001/jamanetworkopen.2019.14779
GLOBAL HEALTH
Nadia Akseer, PhD; Arjumand Rizvi, MSc; Zaid Bhatti, MSc; et al.
This survey study evaluates associations of conflict severity with improvement of health system performance, use of health services, and child nutrition outcomes in Afghanistan during the 2003 to 2018 reconstruction period.
JAMA Netw Open. 2019;2(11):e1914819. doi:10.1001/jamanetworkopen.2019.14819
HEALTH POLICY
Amity E. Quinn, PhD; Brenda R. Hemmelgarn, MD, PhD; Marcello Tonelli, MD, SM; et al.
This population-based cohort study examines the visit frequency, quality of care, and cost for patients with chronic diseases seen by fee-for-service vs salaried specialist physicians.
JAMA Netw Open. 2019;2(11):e1914861. doi:10.1001/jamanetworkopen.2019.14861
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Invited Commentary
Do Salaried Physician Specialists Provide Less Care to Patients With Chronic Disease?
Samaya J. Anumudu, MD; Ahmed A. Awan, MD; Kevin F. Erickson, MD, MS
JAMA Netw Open
GENETICS AND GENOMICS
Yonwoo Jung, PhD; Rachel A. Montel, MS; Pei-Hong Shen, MS; et al.
This meta-analysis examines the association between the D2 dopamine receptor gene (DRD2) and alcohol use disorder.
JAMA Netw Open. 2019;2(11):e1914940. doi:10.1001/jamanetworkopen.2019.14940
SUBSTANCE USE AND ADDICTION
Paul Dietze, PhD; Marianne Jauncey, MPH (Hons); Allison Salmon, PhD; et al.
This randomized clinical trial compares 2 administration methods for the opioid antagonist naloxone in individuals served by a medically supervised drug-injecting facility in Australia.
JAMA Netw Open. 2019;2(11):e1914977. doi:10.1001/jamanetworkopen.2019.14977
EMERGENCY MEDICINE
Robert A. Silverman, MD, MS; Stacey L. House, MD, PhD; Andrew C. Meltzer, MD; et al.
This randomized clinical trial examines the efficacy of an immediate and sustained release oral ondansetron tablet in preventing vomiting for up to 24 hours in adolescents and adults with gastroenteritis.
JAMA Netw Open. 2019;2(11):e1914988. doi:10.1001/jamanetworkopen.2019.14988
PEDIATRICS
Maya Heath, MD; Rebecca Buckley, PhD; Zeromeh Gerber, MD; et al.
This diagnostic study evaluates whether aberrant intestinal alkaline phosphatase biochemistry in infant stool is a molecular biomarker for necrotizing enterocolitis and not associated with sepsis in the absence of necrotizing enterocolitis.
JAMA Netw Open. 2019;2(11):e1914996. doi:10.1001/jamanetworkopen.2019.14996
INFECTIOUS DISEASES
Courtney Ierano, BPharm (Hons); Karin Thursky, MBBS, FRACP, PhD; Caroline Marshall, MBBS, FRACP, PhD; et al.
This quality improvement study uses data from the Australian Surgical National Antimicrobial Prescribing Survey to describe prescribing practices for surgical antimicrobial prophylaxis and assess factors associated with appropriate prescribing.
JAMA Netw Open. 2019;2(11):e1915003. doi:10.1001/jamanetworkopen.2019.15003
CARDIOLOGY
Karina Marshall-Goebel, PhD; Steven S. Laurie, PhD; Irina V. Alferova, MD, PhD; et al.
This cohort study examines the internal jugular vein flow and morphology of crew members of the International Space Station and the use of lower body negative pressure as a countermeasure to the headward fluid shift experienced during space flight.
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JAMA Netw Open. 2019;2(11):e1915011. doi:10.1001/jamanetworkopen.2019.15011
ORTHOPEDICS
Jasvinder A. Singh, MBBS, MPH; Celeste A. Lemay, RN, MPH; Lisa Nobel, PhD; et al.
This cohort study examines patterns of individual pain trajectories after total knee arthroplasty (TKA) and assesses their independent associations with longer-term pain outcome after surgery.
JAMA Netw Open. 2019;2(11):e1915105. doi:10.1001/jamanetworkopen.2019.15105
HEALTH POLICY
Aaron Baum, PhD; Michael L. Barnett, MD, MS; Juan Wisnivesky, MD, DrPH; et al.
This cohort study examines whether long-term changes in chronic disease control were associated with a 6-month decrease in access to health care services among veterans in New York City after superstorm Sandy in October 2012.
JAMA Netw Open. 2019;2(11):e1915111. doi:10.1001/jamanetworkopen.2019.15111
NUTRITION, OBESITY, AND EXERCISE
Filomena Gomes, PhD; Annic Baumgartner, MD; Lisa Bounoure, PhD; et al.
This systematic review and meta-analysis assesses whether nutritional support is associated with better clinical outcomes in medical inpatients who are malnourished or at nutritional risk.
JAMA Netw Open. 2019;2(11):e1915138. doi:10.1001/jamanetworkopen.2019.15138
HEALTH POLICY
Shannon M. Ruzycki, MD, MPH; Georgina Freeman, MSc; Aleem Bharwani, MD, MPP; et al.
This mixed-methods qualitative study explores how physicians in the Department of Medicine at the University of Calgary perceive the climate for women physicians and compares perceptions and experience of gender inequity among physicians based on characteristics including gender, faculty status, parental status, and years in practice.
JAMA Netw Open. 2019;2(11):e1915165. doi:10.1001/jamanetworkopen.2019.15165
DIABETES AND ENDOCRINOLOGY
Liyuan Han, PhD; Dingyun You, PhD; Fangfang Zeng, PhD; et al.
This cross-sectional study examines trends in current measured body mass index (BMI) and weight, self-reported weight, self-perceived weight status, weight loss attempts, and weight loss strategies among adults in the United States using data from the National Health and Nutrition Examination Survey.
JAMA Netw Open. 2019;2(11):e1915219. doi:10.1001/jamanetworkopen.2019.15219
PUBLIC HEALTH
Lian Leng Low, MBBS, MMED; Yu Heng Kwan, BSc; Michelle Shi Min Ko, BSc; et al.
This cross-sectional study conducted in Singapore examines the association between multimorbidity and sociodemographic factors and the association between mental health diseases and physical diseases, as well as their implications for the types and costs of health care use.
JAMA Netw Open. 2019;2(11):e1915245. doi:10.1001/jamanetworkopen.2019.15245
HEALTH INFORMATICS
Kensaku Kawamoto, MD, PhD, MHS; Polina Kukhareva, PhD, MPH; Julie H. Shakib, DO, MS, MPH; et al.
This quality improvement study evaluates whether an electronic health record add-on app for neonatal bilirubin management is associated with clinician time savings and improvements in patient care.
JAMA Netw Open. 2019;2(11):e1915343. doi:10.1001/jamanetworkopen.2019.15343
GERIATRICS
Rebecca T. Emeny, PhD, MPH; Chiang-Hua Chang, PhD; Jonathan Skinner, PhD; et al.
This cohort study estimates hip fracture risk associated with concurrent exposure to multiple fracture-associated drugs.
JAMA Netw Open. 2019;2(11):e1915348. doi:10.1001/jamanetworkopen.2019.15348
HEMATOLOGY
Deborah Lubeck, PhD; Irene Agodoa, MD; Nickhill Bhakta, MD, MPH; et al.
This simulated cohort modeling study compares life expectancy, quality-adjusted life expectancy, and projected lifetime income between individuals with and without sickle cell disease.
JAMA Netw Open. 2019;2(11):e1915374. doi:10.1001/jamanetworkopen.2019.15374
MEDICAL JOURNALS AND PUBLISHING
Elizabeth M. Suelzer, MLIS, AHIP; Jennifer Deal, MA, MLIS; Karen L. Hanus, MLIS, AHIP; et al.
This cross-sectional study analyzes the characteristics of citations from scholarly literature that reference the 1998 article by Wakefield et al and investigates whether authors are accurately citing retracted references.
JAMA Netw Open. 2019;2(11):e1915552. doi:10.1001/jamanetworkopen.2019.15552
SURGERY
Collin W. Blackburn, MBA; Nicolas R. Thompson, MS; Joseph E. Tanenbaum, PhD; et al.
This cohort study assesses whether single-vendor procurement of spinal implants is associated with reduce hospital expenditures without compromising surgical quality.
JAMA Netw Open. 2019;2(11):e1915567. doi:10.1001/jamanetworkopen.2019.15567
HEALTH POLICY
Harlan M. Krumholz, MD, SM; Yongfei Wang, MS; Kun Wang, PhD; et al.
This cohort study analyzes Centers for Medicare & Medicaid Services data for heart failure and pneumonia discharges to ascertain hospital payment profiles associated with hospitalization costs for Medicare beneficiaries.
JAMA Netw Open. 2019;2(11):e1915604. doi:10.1001/jamanetworkopen.2019.15604
PEDIATRICS
Lisa Jamieson, PhD; Lisa Smithers, PhD; Joanne Hedges, MPH; et al.
This secondary analysis of a randomized clinical trial investigates the long-term success of a dental health intervention introduced in a trial involving Aboriginal and Torres Strait Islander children and their mothers in Australia.
JAMA Netw Open. 2019;2(11):e1915611. doi:10.1001/jamanetworkopen.2019.15611
ONCOLOGY
Esther Y. Hsiang, MD, MBA; Shivan J. Mehta, MD, MBA; Dylan S. Small, PhD; et al.
This quality improvement study evaluates the association of an active choice intervention in the electronic health record directed to medical assistants with changes in ordering and patient completion of breast and colorectal cancer screening tests.
JAMA Netw Open. 2019;2(11):e1915619. doi:10.1001/jamanetworkopen.2019.15619
OBSTETRICS AND GYNECOLOGY
Dacia D. C. A. Henriquez, MD; Camila Caram-Deelder, PhD; Saskia le Cessie, PhD; et al.
This cohort study examines the association of timing of receipt of plasma transfusions among women experiencing persistent postpartum hemorrhage with adverse maternal outcomes.
JAMA Netw Open. 2019;2(11):e1915628. doi:10.1001/jamanetworkopen.2019.15628
SUBSTANCE USE AND ADDICTION
Yong-Fang Kuo, PhD; Mukaila A. Raji, MD; James S. Goodwin, MD
This cohort study examines the rate of opioid overdose deaths among Medicare recipients younger than 65 years who qualified for Medicare because of disability.
JAMA Netw Open. 2019;2(11):e1915638. doi:10.1001/jamanetworkopen.2019.15638
HEALTH INFORMATICS
Abhishek Pratap, MS; Ryan Allred, BA; Jaden Duffy, BA; et al.
This mixed-methods survey and qualitative study investigates the association of willingness to participate in biomedical research and share social media data with source of study funding and online recruitment platform.
JAMA Netw Open. 2019;2(11):e1915717. doi:10.1001/jamanetworkopen.2019.15717
ONCOLOGY
Alexander Chi, MD; Wei Fang, PhD; Yeping Sun, MD; et al.
This cohort study compares long-term overall survival of patients with early-stage non–small cell lung cancer treated with stereotactic body radiotherapy vs surgery including various degrees of lymph node examination.
JAMA Netw Open. 2019;2(11):e1915724. doi:10.1001/jamanetworkopen.2019.15724
OBSTETRICS AND GYNECOLOGY
Leticia Torres-Ibarra, MSc; Jack Cuzick, PhD; Attila T. Lorincz, PhD; et al.
This diagnostic study compares the efficiency and effectiveness of 6 triage testing scenarios for screening women with high-risk human papillomavirus (HPV) for referral for colposcopy.
JAMA Netw Open. 2019;2(11):e1915781. doi:10.1001/jamanetworkopen.2019.15781
GLOBAL HEALTH
Harinder Singh Chahal, PharmD, MSc; Kalli Koukounas, MPH; Peter Capella, PhD; et al.
This cross-sectional study analyzes the contributions of the US Food and Drug Administration (FDA) program for reviewing antiretroviral drugs for use in low-resource settings, as well as areas for improvement.
JAMA Netw Open. 2019;2(11):e1915787. doi:10.1001/jamanetworkopen.2019.15787
PSYCHIATRY
Masaya Ito, PhD; Mitsuhiro Miyamae, MA; Chika Yokoyama, PhD; et al.
This trial protocol describes a pilot study that tests the augmentation effect of inaudible, high-frequency sounds on the efficacy of positive valence system–focused cognitive behavioral therapy (CBT) to treat anhedonia.
JAMA Netw Open. 2019;2(11):e1915819. doi:10.1001/jamanetworkopen.2019.15819
ONCOLOGY
Maya Vella, MD; Craig S. Meyer, PhD; Ning Zhang, MS; et al.
This cohort study examines the association of the use of positron emission tomography–computed tomography (PET-CT) and non–small cell lung cancer mortality in the US Department of Veterans Affairs health care system from 2000 to 2013.
JAMA Netw Open. 2019;2(11):e1915828. doi:10.1001/jamanetworkopen.2019.15828
ENVIRONMENTAL HEALTH
Benjamin Bowe, MPH; Yan Xie, MPH; Yan Yan, MD, PhD; et al.
This cohort study identifies causes of death associated with ambient fine particulate matter (PM2.5) air pollution in the United States and estimates the burden of death for each cause.
JAMA Netw Open. 2019;2(11):e1915834. doi:10.1001/jamanetworkopen.2019.15834
MEDICAL EDUCATION
Samuel T. Edwards, MD, MPH; Elizabeth R. Hooker, MS, MPH; Rebecca Brienza, MD, MPH; et al.
This study estimates the association of a multisite interprofessional education initiative in the US Department of Veterans Affairs primary care clinics with quality of care.
JAMA Netw Open. 2019;2(11):e1915943. doi:10.1001/jamanetworkopen.2019.15943
HEALTH POLICY
Brian S. Alper, MD, MSPH; Amy Price, DPhil; Esther J. van Zuuren, MD; et al.
This cross-sectional study examines 8 clinical practice guidelines for consistency in recommendations for diagnosis and management of hypertension.
JAMA Netw Open. 2019;2(11):e1915975. doi:10.1001/jamanetworkopen.2019.15975
CARDIOLOGY
Dennis T. Ko, MD, MSc; Anna Chu, MHSc; Peter C. Austin, PhD; et al.
This cohort study compares cardiac risk factor burden, health services use, and major cardiovascular event incidence between physicians and the general population in Ontario, Canada.
JAMA Netw Open. 2019;2(11):e1915983. doi:10.1001/jamanetworkopen.2019.15983
GLOBAL HEALTH
Joshua C. Grubbs, BA; Roger I. Glass, MD, PhD; Peter H. Kilmarx, MD
This cross-sectional study uses bibliometric analysis to quantify the extent and relevance of international research collaborations funded by the US National Institutes of Health.
JAMA Netw Open. 2019;2(11):e1915989. doi:10.1001/jamanetworkopen.2019.15989
INFECTIOUS DISEASES
Brigid M. Wilson, PhD; Mary T. Bessesen, MD; Gheorghe Doros, PhD; et al.
This cohort study compares amputation and mortality rates among patients treated in the Veterans Health Administration for diabetic foot osteomyelitis with and without rifampin.
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JAMA Netw Open. 2019;2(11):e1916003. doi:10.1001/jamanetworkopen.2019.16003
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Podcast:
Parental and Offspring Use of Marijuana, Tobacco, Alcohol, and Opioids; Rifampin for Diabetic Foot Osteomyelitis
ORTHOPEDICS
Benjamin Y. Li, BS; Kenneth L. Urish, MD, PhD; Bruce L. Jacobs, MD, MPH; et al.
This case-control study evaluates the first year of penalties assessed by the Hospital Readmissions Reduction Program policy of the Centers for Medicare and Medicaid Services to investigate whether an association exists between penalties and surgical volume or characteristics of hospitals or patients undergoing elective total hip arthroplasty or total knee arthroplasty.
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JAMA Netw Open. 2019;2(11):e1916008. doi:10.1001/jamanetworkopen.2019.16008
SUBSTANCE USE AND ADDICTION
Bertha K. Madras, PhD; Beth Han, MD, PhD, MPH; Wilson M. Compton, MD, MPE; et al.
This cross-sectional study examines the associations of parental marijuana use with marijuana, tobacco, and alcohol use and opioid misuse in their adolescent or young adult offspring.
has audio
JAMA Netw Open. 2019;2(11):e1916015. doi:10.1001/jamanetworkopen.2019.16015
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Podcast:
Parental and Offspring Use of Marijuana, Tobacco, Alcohol, and Opioids; Rifampin for Diabetic Foot Osteomyelitis
PUBLIC HEALTH
Shervin Assari, MD, MPH; Cleopatra H. Caldwell, PhD; Mohsen Bazargan, PhD
This cross-sectional study uses data from the Population Assessment of Tobacco and Health survey to explore racial and ethnic differences in the associations between parental educational attainment and youth outcomes among US adolescents.
JAMA Netw Open. 2019;2(11):e1916018. doi:10.1001/jamanetworkopen.2019.16018
CARDIOLOGY
Chenxi Huang, PhD; Shu-Xia Li, PhD; Shiwani Mahajan, MBBS; et al.
This prognostic study quantifies the association of contrast volume during percutaneous coronary intervention with the risk of acute kidney injury, accounting for the possibility of nonlinearity and heterogeneity among different baseline risks.
JAMA Netw Open. 2019;2(11):e1916021. doi:10.1001/jamanetworkopen.2019.16021
ONCOLOGY
Lelia Maria de Almeida Carvalho, MD; Sandra de Oliveira Sapori Avelar, MD; Alyson Haslam, PHD; et al.
This cross-sectional study estimates the potential upper bound of off-label use of erdafitinib to treat advanced cancer with fibroblast growth factor receptor (FGFR) gene alterations, compares it to the upper bound of on-label use in urothelial cancer, and reviews studies that may support off-label use.
JAMA Netw Open. 2019;2(11):e1916091. doi:10.1001/jamanetworkopen.2019.16091
HEALTH POLICY
Karina Pereira-Lima, PhD; Douglas A. Mata, MD, MPH; Sonia R. Loureiro, PhD; et al.
This systematic review and meta-analysis examines whether physician depressive symptoms are associated with the risk for perceived or observed medical errors.
JAMA Netw Open. 2019;2(11):e1916097. doi:10.1001/jamanetworkopen.2019.16097
PHARMACY AND CLINICAL PHARMACOLOGY
Ana-Maria Vilcu, MSc; Laure Sabatte, MD; Thierry Blanchon, MD, PhD; et al.
This cohort study investigates the association between continuous proton pump inhibitor therapy and acute gastroenteritis due to infection with enteric viruses during the 2015 to 2016 winter epidemic in France.
JAMA Netw Open. 2019;2(11):e1916205. doi:10.1001/jamanetworkopen.2019.16205
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Invited Commentary
Further Evidence to Monitor Long-term Proton Pump Inhibitor Use
Kaleen N. Hayes, PharmD; Nardine R. Nakhla, PharmD; Mina Tadrous, PharmD, MS, PhD
JAMA Netw Open
ONCOLOGY
Neil M. Iyengar, MD; Lillian M. Smyth, MD; Diana Lake, MD; et al.
This phase 2 clinical trial evaluates the efficacy and safety of pertuzumab in combination with gemcitabine and trastuzumab after prior treatment with pertuzumab for human epidermal growth factor receptor 2 (ERBB2, formerly HER2)–positive metastatic breast cancer.
JAMA Netw Open. 2019;2(11):e1916211. doi:10.1001/jamanetworkopen.2019.16211
PHARMACY AND CLINICAL PHARMACOLOGY
Joshua J. Fenton, MD, MPH; Alicia L. Agnoli, MD, MPH, MHS; Guibo Xing, PhD; et al.
This cohort study characterizes US trends in opioid dose tapering among patients prescribed long-term opioids from 2008 to 2017 and identifies patient-level variables associated with tapering and a more rapid tapering rate.
JAMA Netw Open. 2019;2(11):e1916271. doi:10.1001/jamanetworkopen.2019.16271
DIABETES AND ENDOCRINOLOGY
Mahiul M. K. Muqit, PhD, FRCOphth; Nick Kourgialis, MA; Meredith Jackson-deGraffenried, PhD; et al.
This cross-sectional study examines a novel fundus photograph–based eye screening model for early detection of diabetic retinopathy to prevent vision loss in Bangladeshi individuals with diabetes.
JAMA Netw Open. 2019;2(11):e1916285. doi:10.1001/jamanetworkopen.2019.16285
SUBSTANCE USE AND ADDICTION
Mehrnaz Ghasemiesfe, MD; Brooke Barrow, BA; Samuel Leonard, MS; et al.
This systematic review and meta-analysis assesses the association of marijuana use with the development of cancer in adults with at least 1 joint-year exposure (equivalent to 1 joint per day for 1 year).
JAMA Netw Open. 2019;2(11):e1916318. doi:10.1001/jamanetworkopen.2019.16318
SURGERY
Ryan Howard, MD; Michael Thompson, PhD, MPH; Zhaohui Fan, MD, MPH; et al.
This cross-sectional study examines the attributable association of modifiable risk factors for adverse outcomes after hernia repair and increased health care spending associated with these adverse outcomes.
JAMA Netw Open. 2019;2(11):e1916330. doi:10.1001/jamanetworkopen.2019.16330
NUTRITION, OBESITY, AND EXERCISE
Usha Gurunathan, MBBS, MD, MEpi, FANZCA; Ivan L. Rapchuk, MD, FRCPC, FANZCA; Marilla Dickfos, MBBS, MSci; et al.
This secondary analysis of the Restrictive vs Liberal Fluid Therapy for Major Abdominal Surgery (RELIEF) randomized clinical trial compares the value of waist circumference with the value of waist-to-hip ratio and body mass index in predicting adverse outcomes, including major septic complications and persistent disability, following major abdominal surgery.
JAMA Netw Open. 2019;2(11):e1916345. doi:10.1001/jamanetworkopen.2019.16345