April 1, 2022 Issue of JAMA Internal Medicine

April 2022, Vol 182, No. 4, Pages 363-463

Original Investigation

Effect of Sleep Extension on Objectively Assessed Energy Intake Among Adults With Overweight in Real-life Settings: A Randomized Clinical Trial

Esra Tasali, MD; Kristen Wroblewski, MS; Eva Kahn, MS; et al.

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JAMA Intern Med. 2022;182(4):365-374. doi:10.1001/jamainternmed.2021.8098

This randomized clinical trial examines the energy intake, energy expenditure, and body weight in adults who slept less than 6.5 hours per night.

Risk of Second Allergic Reaction to SARS-CoV-2 Vaccines: A Systematic Review and Meta-analysis

Derek K. Chu, MD, PhD; Elissa M. Abrams, MD, MPH; David B. K. Golden, MDCM; et al.

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JAMA Intern Med. 2022;182(4):376-385. doi:10.1001/jamainternmed.2021.8515

This systematic review and meta-analysis of case studies and case reports assesses the risk of severe immediate allergic reactions to a second dose of SARS-CoV-2 mRNA vaccine among persons with immediate allergic reactions to their first vaccine dose.

APOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program

Adriana M. Hung, MD, MPH; Shailja C. Shah, MD, MPH; Alexander G. Bick, MD, PhD; et al.

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JAMA Intern Med. 2022;182(4):386-395. doi:10.1001/jamainternmed.2021.8538

This cohort study of US veterans hospitalized with COVID-19 with genetic information and with African ancestry through the VA Million Veteran Program to evaluates the association of APOL1 variations with.acute kidney injury

Association of Physician Management Companies and Private Equity Investment With Commercial Health Care Prices Paid to Anesthesia Practitioners

Ambar La Forgia, PhD; Amelia M. Bond, PhD; Robert Tyler Braun, PhD; et al.

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JAMA Intern Med. 2022;182(4):396-404. doi:10.1001/jamainternmed.2022.0004

This cohort study assesses changes in prices paid to practitioners (anesthesiologists and certified registered nurse anesthetists) before and after an outpatient facility contracted with a physician management company.

Podcast: Physician Management Companies and Commercial Health Care Prices Paid to Anesthesia Practitioners

Mindfulness-Oriented Recovery Enhancement vs Supportive Group Therapy for Co-occurring Opioid Misuse and Chronic Pain in Primary Care: A Randomized Clinical Trial

Eric L. Garland, PhD; Adam W. Hanley, PhD; Yoshio Nakamura, PhD; et al.

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JAMA Intern Med. 2022;182(4):407-417. doi:10.1001/jamainternmed.2022.0033

This randomized clinical trial assesses whether Mindfulness-Oriented Recovery Enhancement is more efficacious than supportive group psychotherapy for reducing opioid misuse among adults with chronic pain receiving long-term opioid therapy.

Association Between Generic-to-Generic Levothyroxine Switching and Thyrotropin Levels Among US Adults

Juan P. Brito, MD, MSc; Yihong Deng, PhD; Joseph S. Ross, MD, MHS; et al.

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JAMA Intern Med. 2022;182(4):418-425. doi:10.1001/jamainternmed.2022.0045

This comparative effectiveness research study examines whether an association exists between switching generic levothyroxine products and changes to serum thyrotropin levels.

Efficacy of Ivermectin Treatment on Disease Progression Among Adults With Mild to Moderate COVID-19 and Comorbidities: The I-TECH Randomized Clinical Trial

Steven Chee Loon Lim, MRCP; Chee Peng Hor, MSc; Kim Heng Tay, MRCP; et al.

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JAMA Intern Med. 2022;182(4):426-435. doi:10.1001/jamainternmed.2022.0189

This randomized clinical trial assesses the efficacy of ivermectin treatment in preventing progression to severe disease among high-risk patients with COVID-19 in Malaysia.

Invited Commentary

Good Sleep, Better Life鈥擡nhancing Health and Safety With Optimal Sleep

Mark R. Rosekind, PhD; Rafael Pelayo, MD; Debra A. Babcock, MD

Abstract Full Text

JAMA Intern Med. 2022;182(4):374-375. doi:10.1001/jamainternmed.2021.8063

Physician Management Companies鈥擲hould We Care?

Francis J. Crosson, MD

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JAMA Intern Med. 2022;182(4):404-406. doi:10.1001/jamainternmed.2022.0001

Podcast: Physician Management Companies and Commercial Health Care Prices Paid to Anesthesia Practitioners

Mistreatment Experienced by Internal Medicine Residents鈥擳he More Things Change, the More They Stay the Same

Natalie L. Richmond, MD; Lara Goitein, MD

Abstract Full Text

JAMA Intern Med. 2022;182(4):450-452. doi:10.1001/jamainternmed.2022.0055

Research Letter

Risk of Immune Thrombocytopenia After Influenza Vaccine

Margaux Lafaurie, PharmD; Maryse Lapeyre-Mestre, MD, PhD; Laurent Sailler, MD, PhD; et al.

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JAMA Intern Med. 2022;182(4):444-445. doi:10.1001/jamainternmed.2021.8523

This cohort study uses data from the French National Health Database to examine the risk of immune thrombocytopenia after receiving influenza vaccine among patients who were 65 years or older.

Association of Financial Strain With Mortality Among Older US Adults Recovering From an Acute Myocardial Infarction

Jason R. Falvey, PT, DPT, PhD; Alexandra M. Hajduk, PhD, MPH; Christopher R. Keys, JD; et al.

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JAMA Intern Med. 2022;182(4):445-448. doi:10.1001/jamainternmed.2021.8569

This cohort study explores the association of severe financial strain with elevated mortality risk following an acute myocardial infarction among US adults older than 75 years.

Physician Work Environment and Well-Being

Prevalence and Sources of Mistreatment Experienced by Internal Medicine Residents

Kathleen M. Finn, MD, MPhil; Alec B. O鈥機onnor, MD, MPH; Kelly McGarry, MD; et al.

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JAMA Intern Med. 2022;182(4):448-450. doi:10.1001/jamainternmed.2022.0051

This survey study examines the prevalence and sources of mistreatment toward internal medicine residents.

Association of County-Level Prescriptions for Hydroxychloroquine and Ivermectin With County-Level Political Voting Patterns in the 2020 US Presidential Election

Michael L. Barnett, MD, MS; Marema Gaye, MA; Anupam B. Jena, MD, PhD; et al.

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JAMA Intern Med. 2022;182(4):452-454. doi:10.1001/jamainternmed.2022.0200

This cross-sectional study examines whether an association exists between US county-level prescription rates of hydroxychloroquine and ivermectin and how people voted in the 2020 US presidential election.

Challenges in Clinical Electrocardiography

Narrow Complex Tachycardias鈥擳herapeutic and Diagnostic Role of Adenosine

Rahul Kumar, MD, DM; Anunay Gupta, MD, DM; Hermohander Singh Isser, MD, DM

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JAMA Intern Med. 2022;182(4):436-437. doi:10.1001/jamainternmed.2021.7764

This case report presents the electrocardiographic findings of a patient in their 40s who presented to the emergency department with sudden-onset rapid palpitations at rest.

Apparent Atrial Dissociation and Electrical Alternans

Laszlo Littmann, MD, PhD

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JAMA Intern Med. 2022;182(4):438-439. doi:10.1001/jamainternmed.2021.8466

This case report presents the electrocardiogram findings of a patient in their 50s with recent hospitalization for tricuspid valve endocarditis who was rehospitalized for worsening shortness of breath.

Unusual Electrocardiographic Findings in an Elderly Patient With Syncope

Yubin Zhang, MD; Tong Liu, MD, PhD; Gan-Xin Yan, MD, PhD

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JAMA Intern Med. 2022;182(4):440-441. doi:10.1001/jamainternmed.2021.8528

This case report describes a patient in their 80s with a history of controlled hypertension who presented to the emergency department with 1 episode of syncope.

An Unusual Cause of ST-Segment Elevation in Lead aVR

Leyu Wang, MD; Shiying Lin, MD; Guanhua Su, MD, PhD

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JAMA Intern Med. 2022;182(4):442-443. doi:10.1001/jamainternmed.2021.8532

This case report presents the electrocardiogram findings of a patient in their 30s with a 5-hour history of palpitation and chest distress that was accompanied by amaurosis and weakness.

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