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October 2024 - January 1908

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Issue

February 2022, Vol 182, No. 2, Pages 99-239

Viewpoint

New Treatments for Migraine—Therapeutic Ratings and Comparative Coverage in the US, Canada, and Europe

Abstract Full Text
JAMA Intern Med. 2022;182(2):101-102. doi:10.1001/jamainternmed.2021.7168

This Viewpoint describes the therapeutic ratings and coverage decisions taken by key bodies across the US, Canada, and Europe.

Original Investigation

Association of Antenatal Diet and Physical Activity–Based Interventions With Gestational Weight Gain and Pregnancy Outcomes: A Systematic Review and Meta-analysis

Abstract Full Text
open access
JAMA Intern Med. 2022;182(2):106-114. doi:10.1001/jamainternmed.2021.6373

This systematic review and meta-analysis reports the implications of various lifestyle interventions for gestational weight gain and maternal and neonatal outcomes.

Efficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized Patients: A Randomized Clinical Trial

Abstract Full Text
open access has active quiz
JAMA Intern Med. 2022;182(2):115-126. doi:10.1001/jamainternmed.2021.6850

This randomized clinical trial examines the use of convalescent plasma from patients with COVID-19 in hospitalized patients with COVID-19 who are not receiving invasive oxygenation treatment.

Less Is More

Longitudinal Content Analysis of the Characteristics and Expected Impact of Low-Value Services Identified in US Choosing Wisely Recommendations

Abstract Full Text
free access
JAMA Intern Med. 2022;182(2):127-133. doi:10.1001/jamainternmed.2021.6911

This qualitative study examines the characteristics and expected impact of 626 Choosing Wisely recommendations.

Association Between Cataract Extraction and Development of Dementia

Abstract Full Text
open access
JAMA Intern Med. 2022;182(2):134-141. doi:10.1001/jamainternmed.2021.6990

This cohort study analyzing data obtained from the Adult Changes in Thought study assesses whether cataract extraction is associated with reduced risk of dementia among adults 65 years of age or older.

Association of Systolic Blood Pressure With Dementia Risk and the Role of Age, U-Shaped Associations, and Mortality

Abstract Full Text
free access
JAMA Intern Med. 2022;182(2):142-152. doi:10.1001/jamainternmed.2021.7009

This cohort study evaluates the risk factors for incident dementia in older individuals, including blood pressure levels.

Association Between Immune Dysfunction and COVID-19 Breakthrough Infection After SARS-CoV-2 Vaccination in the US

Abstract Full Text
free access has active quiz
JAMA Intern Med. 2022;182(2):153-162. doi:10.1001/jamainternmed.2021.7024

This cohort study compares COVID-19 incidence, risk, outcome severity, and treatment response between immunocompromised individuals and those without immune dysfunction conditions before and after SARS-CoV-2 vaccination.

Comparison of SARS-CoV-2 Antibody Response 4 Weeks After Homologous vs Heterologous Third Vaccine Dose in Kidney Transplant Recipients: A Randomized Clinical Trial

Abstract Full Text
open access has active quiz
JAMA Intern Med. 2022;182(2):165-171. doi:10.1001/jamainternmed.2021.7372

This randomized clinical trial evaluated the effectiveness of a third dose of mRNA-based vs a vector-based vaccine in 201 kidney transplant recipients with no SARS-CoV-2 antibodies after 2 prior doses of an mRNA vaccine.

Effectiveness of an Analytics-Based Intervention for Reducing Sleep Interruption in Hospitalized Patients: A Randomized Clinical Trial

Abstract Full Text
free access has audio
JAMA Intern Med. 2022;182(2):172-177. doi:10.1001/jamainternmed.2021.7387

This randomized clinical trial evaluates the use of an algorithm to identify patients in whom nighttime measurement of vital signs can be avoided to prevent interruption of sleep.

Odds of Testing Positive for SARS-CoV-2 Following Receipt of 3 vs 2 Doses of the BNT162b2 mRNA Vaccine

Abstract Full Text
free access has active quiz
JAMA Intern Med. 2022;182(2):179-184. doi:10.1001/jamainternmed.2021.7382

This case-control study evaluates the initial short-term additional benefit of a 3-dose vs a 2-dose vaccine regimen against infection of SARS-CoV-2.

Health Care Policy and Law

Assessment of Hypothetical Out-of-Pocket Costs of Guideline-Recommended Medications for the Treatment of Older Adults With Multiple Chronic Conditions, 2009 and 2019

Abstract Full Text
free access
JAMA Intern Med. 2022;182(2):185-195. doi:10.1001/jamainternmed.2021.7457

This cross-sectional study assesses the out-of-pocket costs associated with guideline-recommended outpatient medications for the initial treatment of 8 common chronic diseases among hypothetical older adults with Medicare prescription drug plans.

Severity of Illness in Persons Infected With the SARS-CoV-2 Delta Variant vs Beta Variant in Qatar

Abstract Full Text
free access has active quiz
JAMA Intern Med. 2022;182(2):197-205. doi:10.1001/jamainternmed.2021.7949

This cohort study assesses the severity of clinical outcomes in persons infected with the SARS-CoV-2 Delta variant vs the Beta variant in Qatar.

Editorial

The Next Frontier of Less Is More—From Description to Implementation

Abstract Full Text
JAMA Intern Med. 2022;182(2):103-105. doi:10.1001/jamainternmed.2021.6908
Invited Commentary

COVID-19 Breakthrough Infection Among Immunocompromised Persons

Abstract Full Text
free access
JAMA Intern Med. 2022;182(2):163-164. doi:10.1001/jamainternmed.2021.7033

A Good Night’s Sleep in the Hospital

Abstract Full Text
has audio
JAMA Intern Med. 2022;182(2):178. doi:10.1001/jamainternmed.2021.7362

Persistent Prescription Drug Affordability Challenges for Medicare Beneficiaries With Multiple Chronic Conditions—What Goes Up Must Come Down?

Abstract Full Text
JAMA Intern Med. 2022;182(2):195-196. doi:10.1001/jamainternmed.2021.7454

Association of Policy Interventions With Tobacco Use Behaviors

Abstract Full Text
JAMA Intern Med. 2022;182(2):234-235. doi:10.1001/jamainternmed.2021.7340
Review

Characterization of the Clinical Evidence Supporting Repository Corticotropin Injection for FDA-Approved Indications: A Scoping Review

Abstract Full Text
JAMA Intern Med. 2022;182(2):206-217. doi:10.1001/jamainternmed.2021.7171

This scoping review characterizes the clinical evidence supporting the use of repository corticotropin for its Food and Drug Administration–approved indications.

Evidence to Practice

Management of Chronic Low Back Pain

Abstract Full Text
JAMA Intern Med. 2022;182(2):222-223. doi:10.1001/jamainternmed.2021.7359

This Evidence to Practice review summarizes recent systematic reviews examining pharmacologic and nonpharmacologic treatments for chronic low back pain.

Teachable Moment

Less Is More

Management of Malignant Pleural Effusions—The Effusion Strikes Back: A Teachable Moment

Abstract Full Text
has active quiz
JAMA Intern Med. 2022;182(2):218-219. doi:10.1001/jamainternmed.2021.6775

This Teachable Moment describes a 66-year-old woman with metastatic non–small cell lung cancer who was referred to the pleural clinic for a recurrent malignant pleural effusion.

Less Is More

To Restrain or Not to Restrain: A Teachable Moment

Abstract Full Text
has active quiz
JAMA Intern Med. 2022;182(2):220-221. doi:10.1001/jamainternmed.2021.7165

This teachable moment discusses issues surrounding the use of restraint in patients with delirium in the intensive care unit.

Research Letter

Changes in the Use of Hydroxyprogesterone Caproate Injection After Confirmatory Trial Failure

Abstract Full Text
free access
JAMA Intern Med. 2022;182(2):226-227. doi:10.1001/jamainternmed.2021.7001

This cross-sectional study examines changes in hydroxyprogesterone caproate fills from 2010 through 2020.

Health Care Policy and Law

Emergency Use Authorizations of COVID-19–Related Medical Products

Abstract Full Text
free access has active quiz
JAMA Intern Med. 2022;182(2):228-229. doi:10.1001/jamainternmed.2021.7257

This cross-sectional study assesses the quality of the process to authorize diagnostic tests, medical devices, and drugs for COVID-19.

Health Care Policy and Law

State Variation in Potentially Burdensome Transitions Among Assisted Living Residents at the End of Life

Abstract Full Text
free access
JAMA Intern Med. 2022;182(2):229-231. doi:10.1001/jamainternmed.2021.7260

This cohort study uses Medicare administrative claims data to describe potentially burdensome transitions among assisted living residents at the end of life and assesses variations by US state.

Association of Cigarette Sales With Comprehensive Menthol Flavor Ban in Massachusetts

Abstract Full Text
free access
JAMA Intern Med. 2022;182(2):231-234. doi:10.1001/jamainternmed.2021.7333

This cohort study examines whether cigarette sales changed after Massachusetts banned menthol-flavored tobacco products.

Lottery-Based Incentives and COVID-19 Vaccination Rates in the US

Abstract Full Text
free access
JAMA Intern Med. 2022;182(2):235-237. doi:10.1001/jamainternmed.2021.7052

This cohort study examines changes in COVID-19 vaccination rates across US states with lottery-based vaccine incentives.

Challenges in Clinical Electrocardiography

Acute Inferior Myocardial Infarction or Not?

Abstract Full Text
JAMA Intern Med. 2022;182(2):224-225. doi:10.1001/jamainternmed.2021.6997

This case report presents the electrocardiogram findings of a patient in their 50s with type 2 diabetes who presented to the emergency department with confusion and falls.

Comment & Response

Digging Deeper for the Truth of a STEMI Mimic

Abstract Full Text
JAMA Intern Med. 2022;182(2):237. doi:10.1001/jamainternmed.2021.7254

Digging Deeper for the Truth of a STEMI Mimic—Reply

Abstract Full Text
JAMA Intern Med. 2022;182(2):237-238. doi:10.1001/jamainternmed.2021.7251

Risks of Changing Estimated Glomerular Filtration Rate Thresholds in Older Persons

Abstract Full Text
JAMA Intern Med. 2022;182(2):238. doi:10.1001/jamainternmed.2021.7344

Risks of Changing Estimated Glomerular Filtration Rate Thresholds in Older Persons—Reply

Abstract Full Text
JAMA Intern Med. 2022;182(2):239. doi:10.1001/jamainternmed.2021.7347
Correction

Omitted Nonauthor Collaborators

Abstract Full Text
free access
JAMA Intern Med. 2022;182(2):239. doi:10.1001/jamainternmed.2021.7668
JAMA Internal Medicine Masthead

JAMA Internal Medicine

Abstract Full Text
free access
JAMA Intern Med. 2022;182(2):99. doi:10.1001/jamainternmed.2021.6062
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