April 10, 2013 Issue of JAMA

April 10, 2013, Vol 309, No. 14, Pages 1433-1544

Special Communication

Clinician's Corner

New Approaches to Molecular Diagnosis

Bruce R. Korf, MD, PhD; Heidi L. Rehm, PhD

Abstract Full Text

JAMA. 2013;309(14):1511-1521. doi:10.1001/jama.2013.3239

Substantial advances in genetic and genomic testing mean that a greater variety of rare genetic and chromosomal disorders can be diagnosed, risk of common disorders can be estimated, and drug treatment can be tailored to individual needs. Korf and Rehm describe how physicians can recognize where new approaches to genetic and genomic testing may be applied clinically.

This Week in JAMA

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JAMA. 2013;309(14):1433. doi:10.1001/jama.2012.145357

Podcast: Genomics Theme Issue

Viewpoint

Realizing the Opportunities of Genomics in Health Care

Geoffrey S. Ginsburg, MD, PhD

Abstract Full Text

JAMA. 2013;309(14):1463-1464. doi:10.1001/jama.2013.1465

The Indispensable Role of Professional Judgment in Genomic Medicine

Amy L. McGuire, JD, PhD; Laurence B. McCullough, PhD; James P. Evans, MD, PhD

Abstract Full Text

JAMA. 2013;309(14):1465-1466. doi:10.1001/jama.2013.1438

Genomic Medicine, Health Information Technology, and Patient Care

Christopher G. Chute, MD, DrPH; Isaac S. Kohane, MD, PhD

Abstract Full Text

JAMA. 2013;309(14):1467-1468. doi:10.1001/jama.2013.1414

Accessing Genomic Medicine: Affordability, Diffusion, and Disparities

Reed V. Tuckson, MD; Lee Newcomer, MD, MHA; Jeanne M. De Sa, MPP

Abstract Full Text

JAMA. 2013;309(14):1469-1470. doi:10.1001/jama.2013.1468

A Piece of My Mind

Preparing for the 21st-Century Patient

Abhishek Pandey

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JAMA. 2013;309(14):1471-1472. doi:10.1001/jama.2012.116971

Original Contribution

Long QT Syndrome鈥揂ssociated Mutations in Intrauterine Fetal Death

Lia Crotti , MD, PhD; David J. Tester, BS; Wendy M. White, MD; et al.

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JAMA. 2013;309(14):1473-1482. doi:10.1001/jama.2013.3219

To determine the spectrum and prevalence of mutations in 3 genes that are most long QT syndrome susceptible, Crotti and coauthors conducted a retrospective postmortem genetic testing analysis on 91 unexplained intrauterine fetal deaths in the United States and Italy.

Editorial
Long QT Syndrome Susceptibility Mutations and Pregnancy Loss: Another Piece of a Still Unfinished Puzzle?
Alan E. Guttmacher, MD; Catherine Y. Spong, MD; Marian Willinger, PhD

JAMA

Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E 系4, and the Risk of Late-Onset Alzheimer Disease in African Americans

Christiane Reitz, MD, PhD; Gyungah Jun, PhD; Adam Naj, PhD; et al.

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JAMA. 2013;309(14):1483-1492. doi:10.1001/jama.2013.2973

To identify genetic variants associated with late-onset Alzheimer disease in African Americans, Reitz and coauthors performed a genome-wide association study using data sets representing 5896 African Americans 60 years or older. Nussbaum provides comment in the related Editorial.

Podcast: Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E e4, and the Risk of Late-Onset Alzheimer Disease in African Americans

Editorial
Genome-Wide Association Studies, Alzheimer Disease, and Understudied Populations
Robert L. Nussbaum, MD

JAMA

Association Between BRAF V600E Mutation and Mortality in Patients With Papillary Thyroid Cancer

Mingzhao Xing, MD, PhD; Ali S. Alzahrani, MD; Kathryn A. Carson, ScM; et al.

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JAMA. 2013;309(14):1493-1501. doi:10.1001/jama.2013.3190

Xing and coauthors conducted a retrospective study among 1849 patients in 7 countries to investigate the relationship between the BRAF V600E mutation and mortality related to papillary thyroid cancer. In an editorial, Cappola and Mandel discuss molecular testing in thyroid cancer.

Editorial
Molecular Testing in Thyroid Cancer: BRAF Mutation Status and Mortality
Anne R. Cappola, MD, ScM; Susan J. Mandel, MD, MPH

JAMA

A Culture-Independent Sequence-Based Metagenomics Approach to the Investigation of an Outbreak of Shiga-Toxigenic Escherichia coli O104:H4

Nicholas J. Loman, MBBS, PhD; Chrystala Constantinidou, PhD; Martin Christner, MD; et al.

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JAMA. 2013;309(14):1502-1510. doi:10.1001/jama.2013.3231

Loman and coauthors report on a culture-independent sequence-based metagenomics approach to the investigation of an outbreak of Shiga-toxigenic Escherichia coli O104:H4. In an accompanying Editorial, Relman discusses metagenomics, infectious disease diagnostics, and outbreak investigations.

Editorial
Metagenomics, Infectious Disease Diagnostics, and Outbreak Investigations: Sequence First, Ask Questions Later?
David A. Relman, MD

JAMA

Editorial

Genomics in Medicine: Maturation, but Not Maturity

W. Gregory Feero, MD, PhD

Abstract Full Text

JAMA. 2013;309(14):1522-1524. doi:10.1001/jama.2013.3818

Long QT Syndrome Susceptibility Mutations and Pregnancy Loss: Another Piece of a Still Unfinished Puzzle?

Alan E. Guttmacher, MD; Catherine Y. Spong, MD; Marian Willinger, PhD

Abstract Full Text

JAMA. 2013;309(14):1525-1526. doi:10.1001/jama.2013.3373

Genome-Wide Association Studies, Alzheimer Disease, and Understudied Populations

Robert L. Nussbaum, MD

Abstract Full Text

JAMA. 2013;309(14):1527-1528. doi:10.1001/jama.2013.3507

Molecular Testing in Thyroid Cancer: BRAF Mutation Status and Mortality

Anne R. Cappola, MD, ScM; Susan J. Mandel, MD, MPH

Abstract Full Text

JAMA. 2013;309(14):1529-1530. doi:10.1001/jama.2013.3620

Metagenomics, Infectious Disease Diagnostics, and Outbreak Investigations: Sequence First, Ask Questions Later?

David A. Relman, MD

Abstract Full Text

JAMA. 2013;309(14):1531-1532. doi:10.1001/jama.2013.3678

Medical News & Perspectives

Genomes of Microbes Inhabiting the Body Offer Clues to Human Health and Disease

M. J. Friedrich

Abstract Full Text

JAMA. 2013;309(14):1447-1449. doi:10.1001/jama.2013.2824

Human Genome Initiatives Make Strides to Better Understand Health and Disease

Tracy Hampton, PhD

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JAMA. 2013;309(14):1449-1451. doi:10.1001/jama.2013.2607

News From the Centers for Disease Control and Prevention

CDC Grand Rounds: The Growing Threat of Multidrug-Resistant Gonorrhea

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JAMA. 2013;309(14):1453-1455. doi:10.1001/jama.2013.2131

Notes from the Field: Multistate Outbreak of Human Salmonella Typhimurium Infections Linked to Contact with Pet Hedgehogs鈥擴nited States, 2011-2013

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JAMA. 2013;309(14):1456. doi:10.1001/jama.2013.1525

QuickStats: Use of Selected Contraception Methods Among Women Aged 15-44 Years Currently Using Contraception鈥擭ational Survey of Family Growth, United States, 1995 and 2006-2010

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JAMA. 2013;309(14):1456. doi:10.1001/jama.2013.249

From JAMA's Daily News Site

Selections From News@JAMA and JAMA Forum

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JAMA. 2013;309(14):1451. doi:10.1001/jama.2013.3159

Capitol Health Call

Animal Drug Regulation

Mike Mitka, MSJ

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JAMA. 2013;309(14):1452. doi:10.1001/jama.2013.2985

Combat Casualty Care Research

Mike Mitka, MSJ

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JAMA. 2013;309(14):1452. doi:10.1001/jama.2013.3559

Delivery System Reform

Mike Mitka, MSJ

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JAMA. 2013;309(14):1452. doi:10.1001/jama.2013.3561

Meth Lab Incidents Increase

Mike Mitka, MSJ

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JAMA. 2013;309(14):1452. doi:10.1001/jama.2013.3563

Letters

Sustained Virological Response to Treatment in Patients With Chronic Hepatitis C

Patrick Maisonneuve, DiplEng; Savino Bruno, MD

Abstract Full Text

JAMA. 2013;309(14):1457. doi:10.1001/jama.2013.2726

Sustained Virological Response to Treatment in Patients With Chronic Hepatitis C鈥擱eply

Adriaan J. van der Meer, MD; Bettina E. Hansen, PhD; Harry L. A. Janssen, MD, PhD

Abstract Full Text

JAMA. 2013;309(14):1457. doi:10.1001/jama.2013.2733

Use of Stem Cells for Ischemic Cardiomyopathy

Guo-You Zhang, MD; Qing-Feng Li, MD, PhD; Xiao-Bing Fu, MD, PhD

Abstract Full Text

JAMA. 2013;309(14):1458-1459. doi:10.1001/jama.2013.2890

Use of Stem Cells for Ischemic Cardiomyopathy鈥擱eply

Joshua M. Hare, MD; Darcy Difede, RN; Alan W. Heldman, MD

Abstract Full Text

JAMA. 2013;309(14):1458-1459. doi:10.1001/jama.2013.2893

Bone Marrow鈥揇erived Cell Therapy After Myocardial Infarction

Lemuel A. Moyé, MD, PhD; Robert D. Simari, MD; Sonia I. Skarlatos, PhD; et al.

Abstract Full Text

JAMA. 2013;309(14):1459-1460. doi:10.1001/jama.2013.2601

Editorial
Mixed Results for Bone Marrow鈥揇erived Cell Therapy for Ischemic Heart Disease
Eduardo Marbán, MD, PhD; Konstantinos Malliaras, MD

JAMA

Bone Marrow鈥揇erived Cell Therapy After Myocardial Infarction鈥擱eply

Eduardo Marbán, MD, PhD; Konstantinos Malliaras, MD

Abstract Full Text

JAMA. 2013;309(14):1459-1460. doi:10.1001/jama.2013.2604

Editorial
Mixed Results for Bone Marrow鈥揇erived Cell Therapy for Ischemic Heart Disease
Eduardo Marbán, MD, PhD; Konstantinos Malliaras, MD

JAMA

Birt-Hogg-Dub茅 Syndrome

Elizabeth Perdeaux, PhD; John Solly, PhD

Abstract Full Text

JAMA. 2013;309(14):1460-1461. doi:10.1001/jama.2013.2243

Birt-Hogg-Dub茅 Syndrome鈥擱eply

Sarah J. Felton, MA, MRCP; Vishal Madan, MD, MRCP

Abstract Full Text

JAMA. 2013;309(14):1460-1461. doi:10.1001/jama.2013.2255

Poetry and Medicine

Love in the SNU

Dawn McGuire, MD

Abstract Full Text

JAMA. 2013;309(14):1438. doi:10.1001/jama.2012.113922

Appendix

Glossary of Genomics Terms

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JAMA. 2013;309(14):1533-1535. doi:10.1001/jama.2013.2950

JAMA Patient Page

Genomic Medicine

Denise M. Goodman, MD, MS; Cassio Lynm, MA; Edward H. Livingston, MD

Abstract Full Text

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JAMA. 2013;309(14):1544. doi:10.1001/jama.2013.1927

Correction

Data Errors in: Extended vs Short-term Buprenorphine-Naloxone for Treatment of Opioid-Addicted Youth: A Randomized Trial

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JAMA. 2013;309(14):1461. doi:10.1001/jama.2012.14679

Data Error in Figures in: Association of Clopidogrel Pretreatment With Mortality, Cardiovascular Events, and Major Bleeding Among Patients Undergoing Percutaneous Coronary Intervention: A Systematic Meta-analysis

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JAMA. 2013;309(14):1461. doi:10.1001/jama.2013.2680

Incorrect Number in Figure in: Effect of Aliskiren on Postdischarge Mortality and Heart Failure Readmissions Among Patients Hospitalized for Heart Failure: The ASTRONAUT Randomized Trial

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JAMA. 2013;309(14):1461. doi:10.1001/jama.2013.3309

JAMA 100 Years Ago

MAN AND MONKEY

Abstract Full Text

JAMA. 2013;309(14):1439. doi:10.1001/jama.2012.145361

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April 10, 2013, Vol 309, No. 14, Pages 1433-1544

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