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October 2024 - January 1929

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January 2021, Vol 139, No. 1, Pages 7-128

Original Investigation

Intense Simulation-Based Surgical Education for Manual Small-Incision Cataract Surgery: The Ophthalmic Learning and Improvement Initiative in Cataract Surgery Randomized Clinical Trial in Kenya, Tanzania, Uganda, and Zimbabwe

Abstract Full Text
open access
JAMA Ophthalmol. 2021;139(1):9-15. doi:10.1001/jamaophthalmol.2020.4718

This randomized clinical trial examines whether adding simulation-based cataract surgical training to conventional training results in improved acquisition of surgical skills among trainees.

Incidence of Drug Use–Related Endogenous Endophthalmitis Hospitalizations in the United States, 2003 to 2016

Abstract Full Text
free access
JAMA Ophthalmol. 2021;139(1):18-26. doi:10.1001/jamaophthalmol.2020.4741

This study investigates changing trends in epidemiology, risk factors, hospital course, and costs associated with drug use–related endogenous endophthalmitis hospitalizations in the United States from 2003 to 2016.

Association of Patterns of Glaucomatous Macular Damage With Contrast Sensitivity and Facial Recognition in Patients With Glaucoma

Abstract Full Text
free access
JAMA Ophthalmol. 2021;139(1):27-32. doi:10.1001/jamaophthalmol.2020.4749

This cohort study evaluates the association of pattern of glaucomatous macular damage with contrast sensitivity and facial recognition among patients with glaucoma.

Diagnostic Test Accuracy of the Red Reflex Test for Ocular Pathology in Infants: A Meta-analysis

Abstract Full Text
free access
JAMA Ophthalmol. 2021;139(1):33-40. doi:10.1001/jamaophthalmol.2020.4854

This systematic review and meta-analysis reviews the literature on diagnostic accuracy of the red reflex test in infant screening for ocular pathologies and provides summary estimates of sensitivity and specificity.

Association of Retinal Vascular Occlusion With Women Filling a Prescription for Female Hormone Therapy

Abstract Full Text
free access
JAMA Ophthalmol. 2021;139(1):42-48. doi:10.1001/jamaophthalmol.2020.4884

This study investigates whether filling a prescription of female hormone therapy (FHT) is associated with an increased risk of retinal artery occlusion (RAO) or retinal vein occlusions (RVO).

Retinal Imaging Findings in Carriers With PSEN1-Associated Early-Onset Familial Alzheimer Disease Before Onset of Cognitive Symptoms

Abstract Full Text
free access
JAMA Ophthalmol. 2021;139(1):49-56. doi:10.1001/jamaophthalmol.2020.4909

This cross-sectional imaging study evaluates whether optical coherence tomography can detect early retinal alterations in carriers of the presenilin 1 (PSEN1) E280A mutation who are cognitively unimpaired.

Insights From Survival Analyses During 12 Years of Anti–Vascular Endothelial Growth Factor Therapy for Neovascular Age-Related Macular Degeneration

Abstract Full Text
free access
JAMA Ophthalmol. 2021;139(1):57-67. doi:10.1001/jamaophthalmol.2020.5044

This cohort study uses data from a tertiary eye center to assess the potential usefulness of survival analyses of 12 years of anti–vascular endothelial growth factor therapy for neovascular age-related macular degeneration.

Efficacy and Safety of a Proposed Ranibizumab Biosimilar Product vs a Reference Ranibizumab Product for Patients With Neovascular Age-Related Macular Degeneration: A Randomized Clinical Trial

Abstract Full Text
open access
JAMA Ophthalmol. 2021;139(1):68-76. doi:10.1001/jamaophthalmol.2020.5053

This randomized clinical trial compares the efficacy, safety, and immunogenicity of SB11, a ranibizumab biosimilar product, with that of the reference ranibizumab for patients with neovascular age-related macular degeneration (AMD).

Factors Associated With Increased Risk of Serious Ocular Injury in the Setting of Orbital Fracture

Abstract Full Text
free access has audio
JAMA Ophthalmol. 2021;139(1):77-83. doi:10.1001/jamaophthalmol.2020.5108

This study identifies clinical and radiographic features that are associated with increased risk of substantial ocular injury in the setting of orbital fracture.

Association of Rhegmatogenous Retinal Detachment Incidence With Myopia Prevalence in the Netherlands

Abstract Full Text
free access
JAMA Ophthalmol. 2021;139(1):85-92. doi:10.1001/jamaophthalmol.2020.5114

This cohort study assesses whether the incidence of rhegmatogenous retinal detachment has changed over recent years and whether this change is associated with an altered prevalence of rhegmatogenous retinal detachment risk factors in the Netherlands.

Association of Anterior Uveitis With Acute Zika Virus Infection in Adults

Abstract Full Text
free access
JAMA Ophthalmol. 2021;139(1):95-102. doi:10.1001/jamaophthalmol.2020.5131

This cohort study uses ophthalmologic examination data from patients evaluated at Pointe-à-Pitre University Hospital to investigate the ocular manifestations of serologically confirmed systemic Zika virus infection.

Brief Report

Ocular Lesions Other Than Stings Following Yellow-Legged Hornet (Vespa velutina nigrithorax) Projections, as Reported to French Poison Control Centers

Abstract Full Text
JAMA Ophthalmol. 2021;139(1):105-108. doi:10.1001/jamaophthalmol.2020.4877

This case series describes ocular lesions occurring after exposure to a liquid projection emitted by a hornet (excluding stings in the eye).

Eye Protection for Patients With COVID-19 Undergoing Prolonged Prone-Position Ventilation

Abstract Full Text
free access
JAMA Ophthalmol. 2021;139(1):109-112. doi:10.1001/jamaophthalmol.2020.4988

This case series describes 2 patients with coronavirus disease 2019 and orbital compartment syndrome, optic disc edema, and retinal hemorrhage in the setting of prolonged prone positioning in the intensive care unit.

Invited Commentary

Redesigning Surgical Training Curriculum With Simulation: Lessons From the OLIMPICS Trial

Abstract Full Text
JAMA Ophthalmol. 2021;139(1):16-17. doi:10.1001/jamaophthalmol.2020.4716

The Enduring Value of Newborn Red Reflex Testing as a Screening Tool

Abstract Full Text
JAMA Ophthalmol. 2021;139(1):40-41. doi:10.1001/jamaophthalmol.2020.4853

The Big Influence of Small Data in Emergency Assessment of Serious Ocular Injury

Abstract Full Text
JAMA Ophthalmol. 2021;139(1):83-84. doi:10.1001/jamaophthalmol.2020.5107

Will the Myopia Epidemic Lead to a Retinal Detachment Epidemic in the Future?

Abstract Full Text
JAMA Ophthalmol. 2021;139(1):93-94. doi:10.1001/jamaophthalmol.2020.5112

Zika Virus and Anterior Uveitis—4 Years After the Pandemic

Abstract Full Text
JAMA Ophthalmol. 2021;139(1):103-104. doi:10.1001/jamaophthalmol.2020.5138
Special Communication

Development, Validation, and Innovation in Ophthalmic Laser-Based Imaging: Report From a US Food and Drug Administration–Cosponsored Forum

Abstract Full Text
JAMA Ophthalmol. 2021;139(1):113-118. doi:10.1001/jamaophthalmol.2020.4994

This Special Communication describes a forum of laser-based imaging cosponsored by the US Food and Drug Administration and 11 professional ophthalmic, vision science, and optometric societies.

JAMA Ophthalmology Clinical Challenge

Persistent Red Eye Unresponsive to Topical Treatment

Abstract Full Text
JAMA Ophthalmol. 2021;139(1):119-120. doi:10.1001/jamaophthalmol.2020.4062

A 68-year-old woman has a 3-week history of progressive eye redness and discomfort unresponsive to topical treatment. What would you do next?

A Child With Acute Eyelid Edema and Proptosis

Abstract Full Text
JAMA Ophthalmol. 2021;139(1):121-122. doi:10.1001/jamaophthalmol.2020.4067

A 2-year-old girl presents with 2 days of left upper eyelid swelling after vomiting caused by a viral illness. What would you do next?

Progressive Eyelid Swelling in a Middle-aged Man

Abstract Full Text
JAMA Ophthalmol. 2021;139(1):123-124. doi:10.1001/jamaophthalmol.2020.4092

A man in his 40s presents with a recent history of pain and swelling over his right orbit and upper eyelid, and computed tomography shows a right supraorbital abscess with mass effect. What would you do next?

Recurrent Subconjunctival Hemorrhage in a Child With an Orbital Mass

Abstract Full Text
JAMA Ophthalmol. 2021;139(1):125-126. doi:10.1001/jamaophthalmol.2020.4087

A 14-month-old girl presents with recurrent left subconjunctival hemorrhage with increasing frequency in the past 7 months, with a large inferior orbital lesion measuring more than 17 mm shown during B-scan examination. What would you do next?

Ophthalmic Images

Idiopathic Corneal Hemorrhage

Abstract Full Text
online only
JAMA Ophthalmol. 2021;139(1):e204053. doi:10.1001/jamaophthalmol.2020.4053

This case report describes a rare idiopathic case of corneal hemorrhage.

Pigmented Iris Lesion on Anterior-Segment Swept-Source Optical Coherence Tomography

Abstract Full Text
online only
JAMA Ophthalmol. 2021;139(1):e204079. doi:10.1001/jamaophthalmol.2020.4079

This case report describes an iris pigment epithelium cyst, a disease that can mimic ciliary body melanoma.

Arterial Wall Hyperfluorescence in Susac Syndrome

Abstract Full Text
online only
JAMA Ophthalmol. 2021;139(1):e204100. doi:10.1001/jamaophthalmol.2020.4100

This case report describes a diagnosis of Susac syndrome in a man presenting with a superior visual field deficit in his left eye.

Spontaneous Regression of Presumed Ocular Surface Squamous Neoplasia

Abstract Full Text
online only
JAMA Ophthalmol. 2021;139(1):e204149. doi:10.1001/jamaophthalmol.2020.4149

This case report describes a woman with a presumed ocular surface squamous neoplasia that spontaneously regressed before excisional biopsy and diagnostic confirmation.

Comment & Response

Studies of Microsurgical Skill—The Key Lies in the Design

Abstract Full Text
JAMA Ophthalmol. 2021;139(1):127. doi:10.1001/jamaophthalmol.2020.4755

Studies of Microsurgical Skill—The Key Lies in the Design—Reply

Abstract Full Text
JAMA Ophthalmol. 2021;139(1):127-128. doi:10.1001/jamaophthalmol.2020.4758
JAMA Ophthalmology Masthead

JAMA Ophthalmology

Abstract Full Text
free access
JAMA Ophthalmol. 2021;139(1):7. doi:10.1001/jamaophthalmol.2020.3737
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