Shahram Oveisgharan, MD; Robert S. Wilson, PhD; Lei Yu, PhD; et al.
free access
JAMA Neurol. 2020;77(10):1217-1224. doi:10.1001/jamaneurol.2020.1941
This cohort study examines the association of early-life cognitive enrichment with late-life Alzheimer disease and other common dementia-related pathological changes in an autopsy sample.
Andrea O. Rossetti, MD; Kaspar Schindler, MD, PhD; Raoul Sutter, MD; et al.
open access
has audio
JAMA Neurol. 2020;77(10):1225-1232. doi:10.1001/jamaneurol.2020.2264
This randomized clinical trial investigates whether continuous electroencephalogram is associated with reduced mortality compared with routine electroencephalogram.
-
Podcast:
Continuous vs Routine Electroencephalogram in Critically Ill Adults With Altered Consciousness
Roland Veltkamp, MD; Lesly A. Pearce, MS; Eleni Korompoki, MD; et al.
free access
JAMA Neurol. 2020;77(10):1233-1240. doi:10.1001/jamaneurol.2020.1995
This secondary analysis of a randomized clinical trial assesses the subtype of recurrent ischemic stroke after embolic stroke of underdetermined source, the interaction with treatment assignment, and the consistency of cerebral location of the qualifying and recurrent strokes in the study population of the NAVIGATE-ESUS trial.
Eileen B. Leary, PhD, RPSGT; Kathleen T. Watson, MS; Sonia Ancoli-Israel, PhD; et al.
free access
JAMA Neurol. 2020;77(10):1241-1251. doi:10.1001/jamaneurol.2020.2108
This cross-sectional study investigates whether rapid eye movement sleep is associated with greater risk of mortality in 2 independent cohorts and explores whether another sleep stage could be driving these findings.
Vasileios-Arsenios Lioutas, MD; Alexa S. Beiser, PhD; Hugo J. Aparicio, MD; et al.
free access
JAMA Neurol. 2020;77(10):1252-1260. doi:10.1001/jamaneurol.2020.1512
This cohort study examines data from original and offspring participants in the Framingham Heart Study to assess the incidence of intracerebral hemorrhage, incidence rates stratified by deep and lobar brain locations, and location-specific risk factors between 1948 and 2016.
Robert W. Regenhardt, MD, PhD; Jesse M. Thon, MD; Alvin S. Das, MD; et al.
free access
JAMA Neurol. 2020;77(10):1261-1269. doi:10.1001/jamaneurol.2020.1782
This cohort study examines the clinical, neuroimaging, laboratory, pathologic, or treatment-related associations with outcomes after an episode of cerebral amyloid angiopathy-related inflammation.
Yue Leng, MD, PhD; Terri Blackwell, MA; Peggy M. Cawthon, PhD; et al.
free access
JAMA Neurol. 2020;77(10):1270-1278. doi:10.1001/jamaneurol.2020.1623
This cohort study assesses the association between rest-activity rhythm and risk of incident Parkinson disease and explores whether this association is independent of nighttime sleep disturbances in community-dwelling older men.
Sara Mazzucco, MD, PhD; Linxin Li, MD, DPhil; Peter M. Rothwell, MD, PhD
open access
JAMA Neurol. 2020;77(10):1279-1287. doi:10.1001/jamaneurol.2020.1948
This systematic review and meta-analysis examines the recurrence of ischemic stroke and possible use of patent foramen ovale closure in patients aged 60 years or older.
Neha S. Raghavan, PhD; Logan Dumitrescu, PhD; Elizabeth Mormino, PhD; et al.
free access
JAMA Neurol. 2020;77(10):1288-1298. doi:10.1001/jamaneurol.2020.1760
This genetic association study examines amyloid levels through positron emission tomographic imaging in individuals with or at risk for Alzheimer disease.
Shama Karanth, MDS; Peter T. Nelson, MD, PhD; Yuriko Katsumata, PhD; et al.
free access
JAMA Neurol. 2020;77(10):1299-1307. doi:10.1001/jamaneurol.2020.1741
This cohort study examines brain autopsy data for the presence of quadruple misfolded proteins (tau, amyloid-尾, 伪-synuclein, and transactive response DNA-binding protein 43) and their association with cognitive decline in older adults.