ÌÇÐÄvlog

Arellano and coauthors aim to identify linear determinants of hAQP4 in the context of HLA-DRb1*03:01. See also the editorial by ¹⁵⁶¹.

Orange and colleagues conducted a retrospective case series of 26 patients with paraneoplastic neurologic disorders (PNDs) to evaluate the short-term use of a combination of prednisone and tacrolimus for acute neurologic worsening in PND in which intracellular antigens are targeted.

Smith and coauthors used an open-label trial to test the hypotheses that deep brain stimulation would increase cerebral glucose metabolism in cortical and hippocampal circuits and that increased metabolism would be correlated with better clinical outcomes.

Takada et al describe the clinical features of a Brazilian kindred with C9orf72 frontotemporal dementia–amyotrophic lateral sclerosis and compare them with other described families with C9orf72 and frontotemporal dementia–amyotrophic lateral sclerosis–causing mutations.

To delineate the molecular basis of amyotrophic lateral sclerosis (ALS) in the Kii peninsula of Japan, Ishiura and colleagues analyzed hexanucleotide repeat expansion in the chromosome 9 open reading frame 72 gene (C9ORF72).

Daoud et al assess the presence of a large hexanucleotide repeat expansion in the first intron of the C9orf72 gene, identified as the genetic cause of chromosome 9p21–linked amyotrophic lateral sclerosis and frontotemporal dementia, in 4 unrelated families.

Savica and colleagues conducted a clinical series to characterize the antemortem characteristics of a family with frontotemporal dementia (FTD) and/or amyotrophic lateral sclerosis (ALS) linked to chromosome 9 (c9FTD/ALS) associated with the GGGGCC repeat expansion in the chromosome 9 open reading frame 72 (C9ORF72) gene.

In a prospective cohort study, Yaffe et al determine if prevalent and incident diabetes mellitus increase risk of cognitive decline and if, among elderly adults with diabetes mellitus, poor glucose control is related to worse cognitive performance.

With a prevalence of approximately 1% to 2% that of multiple sclerosis, neuromyelitis optica (NMO) and its spectrum disorders are rare in the United States. Mealy and coauthors developed a multicenter NMO clinical consortium of 3 tertiary centers to facilitate accurate clinical diagnosis and establish a foundation for future research.

Dorothée and colleagues compare serum antiamyloid-β antibodies in typical and atypical Alzheimer disease using an oligomer-based enzyme-linked immunosorbent assay.

Dassan and coauthors used a cross-sectional study to investigate whether vascular endothelial growth factor (VEGF) levels are associated with the presence of cerebral microbleeds in patients after acute ischemic stroke.