As with airplane concepts, clinical trials fly or crash based on design engineering. Executing a well-designed trial that asks a clinically important question of a common problem is harder than it sounds. Vertiginous uplift requires gravity-defying kinetics by a dedicated and coordinated team, akin to climbing mountains. The final yards (writing and publishing) are, like the summit, the hardest, requiring commitment, focus, and an eye on the end game. Others in this fine series of articles on scientific endeavor covered the conceptualization, initiation, planning, and aggregation of trial data. Now it is time to publish (Box). What makes a trial stand out to editors and referees? Simplicity, as in nature, is the most elegant form to achieve.