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This prospective case-control study nested in 3 large, well-established, prospective US cohorts examines whether the oral bacterial and fungal microbiome is associated with subsequent head and neck squamous cell cancer risk.

This cohort study examines 3-year survival among patients with hepatocellular carcinoma placed on a watch-and-wait protocol after achieving complete remission with combined locoregional therapy and immunotherapy.

A 36-year-old man presented with 10 weeks of recurrent fevers, malaise, night sweats, unintentional weight loss, and dyspnea. What is your diagnosis?

This Viewpoint explores how guideline groups can come together to agree on a framework that produces clear and unified recommendations.

This nonrandomized clinical trial examines the safety and efficacy of guanylate cyclase-C (GCC) chimeric antigen receptor T-cell therapy in patients with metastatic colorectal cancer.

This nonrandomized clinical trial evaluates the safety, pharmacokinetics, and preliminary efficacy of rogaratinib in combination with the programmed cell death 1 ligand 1 inhibitor atezolizumab in cisplatin-ineligible patients with FGFR messenger RNA–positive, locally advanced/metastatic urothelial cancer.

This randomized clinical trial examines whether stereotactic body radiotherapy improves local control compared with hypofractionated conventional radiotherapy.

This randomized clinical trial compares the effect of transperineal vs transrectal prostate biopsy on infection rates after biopsy.

This Viewpoint discusses how the inclusion or exclusion of certain events in the standardization of clinical trial end points can affect the interpretation of results.

This single-center cohort study examines the association of molecular, socioeconomic, and clinical covariates with race and ethnicity disparities in overall survival among patients with colorectal cancer.

This cross-sectional study examines the population-based incidence of cervical cancer in 6 US-Affiliated Pacific Islands from 2007 to 2020.

This cohort study examines the risk of radiation-associated sarcoma in patients with breast cancer harboring germline TP53 variants.

This review analyzes the heterogeneity of residual disease after neoadjuvant systemic therapy in patients with breast cancer.

This Viewpoint discusses accrual difficulties of radiotherapy cooperative group trials and proposes solutions.

This cross-sectional study of data from the Agency for Healthcare Research and Quality’s Healthcare Cost and Utilization Project National Inpatient Sample investigates whether housing status is associated with the receipt of inpatient care and outcomes among hospitalized adults with cancer who are experiencing homelessness.

This cross-sectional study examines clinicogenomic features of Lynch syndrome and characterizes responses to immune checkpoint blockade therapy.

This study reanalyzes epidermal growth factor receptor 2 (ERBB2) data from a previous study to characterize patient subgroups with ERBB2-low tumors.

This essay describes a physician’s shift to patient-focused language in treatment of patients with cancer.