NEUROLOGY
Shima Shahjouei, MD, MPH; Jiang Li, MD, PhD; Eric Koza, BS; et al.
This systematic review and meta-analysis compares the risk of subsequent ischemic stroke among patients with transient ischemic attack (TIA) or minor ischemic stroke who received care at rapid-access TIA or neurology clinics, inpatient units, emergency departments, and unspecified or multiple settings.
JAMA Netw Open. 2022;5(1):e2136644. doi:10.1001/jamanetworkopen.2021.36644
PSYCHIATRY
Paula P. Schnurr, PhD; Kathleen M. Chard, PhD; Josef I. Ruzek, PhD; et al.
This randomized clinical trial compares the effectiveness of prolonged exposure vs cognitive processing therapy for treating posttraumatic stress disorder in veterans.
JAMA Netw Open. 2022;5(1):e2136921. doi:10.1001/jamanetworkopen.2021.36921
INFECTIOUS DISEASES
Jesús Sojo-Dorado, MD, PhD; Inmaculada López-Hernández, MD, PhD; Clara Rosso-Fernandez, MD, PhD; et al.
This randomized clinical trial investigates noninferiority of fosfomycin vs ceftriaxone or meropenem in achieving clinical and microbiological cure among patients with urinary tract infections due to multidrug-resistant Escherichia coli.
JAMA Netw Open. 2022;5(1):e2137277. doi:10.1001/jamanetworkopen.2021.37277
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Invited Commentary
The Role of Intravenous Fosfomycin: Finding Our Way Out of Dante鈥檚 Forest Dark
Pranita D. Tamma, MD, MHS; Robert A. Bonomo, MD; Usha Stiefel, MD
JAMA Netw Open
PUBLIC HEALTH
Josiemer Mattei, PhD; Martha Tamez, ScD; June O鈥橬eill, MPH; et al.
This cross-sectional study assesses the prevalence of chronic diseases and their associated risk factors among adults living in Puerto Rico before vs after Hurricane Maria.
JAMA Netw Open. 2022;5(1):e2139986. doi:10.1001/jamanetworkopen.2021.39986
SURGERY
Shipra Arya, MD, SM; Ashley H. Langston, MS, MA; Rui Chen, MS; et al.
This mixed-methods study including a survey and qualitative interviews of US veterans who underwent inpatient surgery assesses whether the percentage of time spent at home after surgery was associated with quality of life, function, and decisional regret after surgery.
JAMA Netw Open. 2022;5(1):e2140196. doi:10.1001/jamanetworkopen.2021.40196
HEALTH POLICY
Peggah Khorrami, MPH; Michael S. Sinha, MD, JD, MPH; Aditi Bhanja, MPH; et al.
This cross-sectional study compares diabetic drug utilization and cost patterns between Colorado Medicaid and Marketplace health insurance plans during 2014 and 2015.
JAMA Netw Open. 2022;5(1):e2140371. doi:10.1001/jamanetworkopen.2021.40371
PSYCHIATRY
Denise M. Sloan, PhD; Brian P. Marx, PhD; Patricia A. Resick, PhD; et al.
This randomized noninferiority trial investigates whether a 5-session written exposure therapy is noninferior in the treatment of posttraumatic stress disorder (PTSD) vs 10-session cognitive processing therapy among service members diagnosed with PTSD.
JAMA Netw Open. 2022;5(1):e2140911. doi:10.1001/jamanetworkopen.2021.40911
PEDIATRICS
Thomas S. Murray, MD, PhD; Amyn A. Malik, MBBS, MPH, PhD; Mehr Shafiq, MPH; et al.
This survey study assesses whether child masking policies are associated with COVID-19鈥搑elated childcare program closures.
has active quiz
has audio
JAMA Netw Open. 2022;5(1):e2141227. doi:10.1001/jamanetworkopen.2021.41227
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Audio:
Association of Child Masking With COVID-19 Childcare Program Closures
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Audio:
Association of Child Masking With COVID-19 Childcare Program Closures
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Podcast:
Association of Child Masking With COVID-19 Childcare Program Closures
ONCOLOGY
Vasily Giannakeas, MPH; Joanne Kotsopoulos, PhD; Matthew C. Cheung, MD; et al.
This case-control study evaluates the association of an elevated platelet count with risk of cancer by cancer type and time from a complete blood count test to cancer diagnosis.
JAMA Netw Open. 2022;5(1):e2141633. doi:10.1001/jamanetworkopen.2021.41633
CARDIOLOGY
Yun Gi Kim, MD; Kwang-No Lee, MD, PhD; Kyung-Do Han, PhD; et al.
This cohort study uses data from the Korean National Health Insurance Service database to assess the association of depression with the development of new-onset atrial fibrillation.
JAMA Netw Open. 2022;5(1):e2141772. doi:10.1001/jamanetworkopen.2021.41772
CARDIOLOGY
Dariush Mozaffarian, MD, DrPH; Kevin C. Maki, PhD; Harold E. Bays, MD; et al.
This study of pooled data from 2 randomized clinical trials compares the efficacy and safety of a novel 蠅-3鈥損hospholipid/free fatty acid to lower triglyceride levels in patients with hypertriglyceridemia.
JAMA Netw Open. 2022;5(1):e2141898. doi:10.1001/jamanetworkopen.2021.41898
GENETICS AND GENOMICS
David E. Godler, PhD; Ling Ling, MD; Dinusha Gamage, MS; et al.
This diagnostic study examines the feasibility of screening newborns for the chromosome 15 imprinting disorders Angelman syndrome, Prader-Willi syndrome, and chromosome 15 duplication syndrome using SNRPN methylation analysis.
JAMA Netw Open. 2022;5(1):e2141911. doi:10.1001/jamanetworkopen.2021.41911
ONCOLOGY
Yagiz U. Yolcu, MD; Jad Zreik, BS; Waseem Wahood, MS; et al.
This cohort study examines the use of carbon ion radiotherapy as treatment vs en bloc surgical resection in patients with sacral chordoma.
JAMA Netw Open. 2022;5(1):e2141927. doi:10.1001/jamanetworkopen.2021.41927
SUBSTANCE USE AND ADDICTION
Sean Esteban McCabe, PhD; John E. Schulenberg, PhD; Ty S. Schepis, PhD; et al.
This cohort study identifies 32-year prescription drug misuse trajectories involving opioids, stimulants, and sedatives or tranquilizers and examines associations between these trajectories, substance use disorder (SUD) symptoms in adulthood, and baseline characteristics.
JAMA Netw Open. 2022;5(1):e2141995. doi:10.1001/jamanetworkopen.2021.41995
ONCOLOGY
Jessica E. Hawley, MD; Tianyi Sun, MS; David D. Chism, MD; et al.
This cohort study examines spatiotemporal variation in COVID-19 outcomes among patients with cancer in the United States.
JAMA Netw Open. 2022;5(1):e2142046. doi:10.1001/jamanetworkopen.2021.42046
INFECTIOUS DISEASES
Johannes Forster, MD; Andrea Streng, PhD; Paul Rudolph, MSc; et al.
This nonrandomized controlled trial investigates the feasibility of SARS-CoV-2 surveillance among children and childcare workers at day care centers in Germany and models the efficacy of surveillance for preventing viral spread.
JAMA Netw Open. 2022;5(1):e2142057. doi:10.1001/jamanetworkopen.2021.42057
PHYSICAL MEDICINE AND REHABILITATION
Meng-Si Peng, MSc; Rui Wang, MSc; Yi-Zu Wang, MSc; et al.
This randomized clinical trial evaluates the use of therapeutic aquatic exercise vs physical therapy in individuals with chronic low back pain.
JAMA Netw Open. 2022;5(1):e2142069. doi:10.1001/jamanetworkopen.2021.42069
CARDIOLOGY
Mukul Bhattarai, MD, MPH; Mohsin Salih, MD, MS; Manjari Regmi, MD; et al.
This meta-analysis assesses whether use of sodium-glucose cotransporter 2 inhibitors (SFLT2-Is) is associated with cardiovascular benefits in patients with atherosclerotic cardiovascular disease or its risk factors, diabetes, or heart failure
JAMA Netw Open. 2022;5(1):e2142078. doi:10.1001/jamanetworkopen.2021.42078
ONCOLOGY
Mallika Marar, MD, MBA; Qi Long, PhD; Ronac Mamtani, MD, MSCE; et al.
This cohort study of African American and non-Hispanic White men uses the Flatiron Health database to examine survival outcomes associated with first-line abiraterone therapy for metastatic castration-resistant prostate cancer.
JAMA Netw Open. 2022;5(1):e2142093. doi:10.1001/jamanetworkopen.2021.42093
PEDIATRICS
Joëlle N. Albrecht, MSc; Helene Werner, PhD; Noa Rieger, BSc; et al.
This survey study investigates the associations between sleep behaviors and adolescents鈥 health-related characteristics during COVID-19 pandemic high school closures in Switzerland.
JAMA Netw Open. 2022;5(1):e2142100. doi:10.1001/jamanetworkopen.2021.42100
PEDIATRICS
Thijs A. Lilien, MD; Nina S. Groeneveld, BSc; Faridi van Etten-Jamaludin, Bc; et al.
his systematic review and meta-analysis assesses outcomes associated with arterial hyperoxia in critically ill children.
JAMA Netw Open. 2022;5(1):e2142105. doi:10.1001/jamanetworkopen.2021.42105
INFECTIOUS DISEASES
Sumit Malhotra, MD; Kalaivani Mani, PhD; Rakesh Lodha, MD; et al.
This cohort study assesses the SARS-CoV-2 reinfection rate and estimated effectiveness of the inactivated whole virion vaccine BBV152 against reinfection among health care workers in New Delhi, India.
has active quiz
JAMA Netw Open. 2022;5(1):e2142210. doi:10.1001/jamanetworkopen.2021.42210
GERIATRICS
Kazuhiro Abe, PhD; Ichiro Kawachi, PhD; Yuta Taniguchi, MD; et al.
This cross-sectional study assesses whether municipal characteristics are associated with in-home deaths vs deaths outside the home among older Japanese adults.
JAMA Netw Open. 2022;5(1):e2142273. doi:10.1001/jamanetworkopen.2021.42273
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Invited Commentary
End-of-Life Preferences in Older US Adults鈥擝ridging the 鈥淲hat Matters鈥 Chasm
Anand S. Iyer, MD, MSPH; Cynthia J. Brown, MD, MSPH
JAMA Netw Open
PEDIATRICS
Anna L. Funk, PhD, MSc; Todd A. Florin, MD, MSCE; Nathan Kuppermann, MD, MPH; et al.
This cohort study investigates the prevalence of severe outcomes among youths aged 17 years or younger within 14 days of testing positive for SARS-CoV-2 in emergency departments in 8 countries.
has active quiz
JAMA Netw Open. 2022;5(1):e2142322. doi:10.1001/jamanetworkopen.2021.42322
NEPHROLOGY
Bryce A. Kiberd, MD; Amanda Vinson, MD, SM; Philip D. Acott, MD; et al.
This decision analytical model assesses conditions that favor a deceased donor transplant followed by a live donor transplant sequence or vice versa in pediatric patients with kidney failure.
JAMA Netw Open. 2022;5(1):e2142331. doi:10.1001/jamanetworkopen.2021.42331
OBSTETRICS AND GYNECOLOGY
Sarahn M. Wheeler, MD; Sabrena O. Myers, BS; Geeta K. Swamy, MD; et al.
This cohort study estimates the population-level prevalence of preeclampsia risk factors used in prophylactic low-dose aspirin guidelines for pregnant patients and the association of these risk factors with reported rates of pregnancy-related hypertension.
JAMA Netw Open. 2022;5(1):e2142343. doi:10.1001/jamanetworkopen.2021.42343
RHEUMATOLOGY
Ted R. Mikuls, MD, MSPH; Quint Soto, MD; Alison Petro, MS; et al.
This cohort study of patients from the US Department of Veterans Affairs Health System compares the rates of lower extremity amputations in patients with and without gout, as well as factors that might be associated with differences.
JAMA Netw Open. 2022;5(1):e2142347. doi:10.1001/jamanetworkopen.2021.42347
DIABETES AND ENDOCRINOLOGY
Charles de Mestral, MDCM, PhD; David Gomez, MD, PhD; Andrew S. Wilton, MSc; et al.
This cohort study evaluates the association of the COVID-19 pandemic with diabetes-related care measures, foot complications, and amputation among adults in Ontario, Canada.
JAMA Netw Open. 2022;5(1):e2142354. doi:10.1001/jamanetworkopen.2021.42354
HEALTH POLICY
Erwin Wang, MD, MHA; Sonia Arnold, MBA; Simon Jones, PhD; et al.
This quality improvement study assesses a full-integration approach to hospital mergers using quality metrics that track hospital mortality and readmission.
JAMA Netw Open. 2022;5(1):e2142382. doi:10.1001/jamanetworkopen.2021.42382
GLOBAL HEALTH
Fanny Petermann-Rocha, PhD; Nirmala Rao, PhD; Jill P. Pell, MD; et al.
This cross-sectional study examines the combined association of weight-for-height z score and body fat with early childhood development in the East Asia and Pacific region.
JAMA Netw Open. 2022;5(1):e2142458. doi:10.1001/jamanetworkopen.2021.42458
SUBSTANCE USE AND ADDICTION
Danielle R. Fine, MD, MSc; Kirsten A. Dickins, PhD, FNP-C; Logan D. Adams, MD; et al.
This cohort study describes the death rates and drug types involved in fatal drug overdoses in the past 15 years among individuals experiencing homelessness in Boston, Massachusetts.
JAMA Netw Open. 2022;5(1):e2142676. doi:10.1001/jamanetworkopen.2021.42676
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Invited Commentary
Overdose and Homelessness鈥擶hy We Need to Talk About Housing
Kelly M. Doran, MD, MHS; Callan Elswick Fockele, MD, MS; Marcella Maguire, PhD
JAMA Netw Open
SUBSTANCE USE AND ADDICTION
Marguerite E. Burns, PhD; Steven Cook, MS; Lars M. Brown, MA; et al.
This cohort study evaluates whether a prerelease Medicaid enrollment assistance program was associated with increased health care use within 30 days after release from prison.
JAMA Netw Open. 2022;5(1):e2142688. doi:10.1001/jamanetworkopen.2021.42688
RHEUMATOLOGY
Daniel I. Rhon, DPT, DSc, PhD; Minchul Kim, PhD; Carl V. Asche, PhD; et al.
This economic evaluation compares the cost-effectiveness of physical therapy vs intra-articular glucocorticoid injection as initial treatment strategies for knee osteoarthritis.
JAMA Netw Open. 2022;5(1):e2142709. doi:10.1001/jamanetworkopen.2021.42709
PUBLIC HEALTH
Daniel H. Solomon, MD, MPH; Alicia Colvin, PhD; Brittney S. Lange-Maia, PhD; et al.
This cohort study examines factors associated with clinically important 10-year declines in the physical health of US women from age 55 to 65 years.
JAMA Netw Open. 2022;5(1):e2142773. doi:10.1001/jamanetworkopen.2021.42773
NEUROLOGY
Chanjira Satukijchai, MD; Romina Mariano, DPhil; Silvia Messina, MD; et al.
This cohort study investigates factors associated with long-term risk of relapse among patients with myelin oligodendrocyte glycoprotein antibody鈥揳ssociated disease in the United Kingdom.
JAMA Netw Open. 2022;5(1):e2142780. doi:10.1001/jamanetworkopen.2021.42780
INFECTIOUS DISEASES
Helen C. Stankiewicz Karita, MD, MSc; Tracy Q. Dong, PhD; Christine Johnston, MD, MPH; et al.
This cohort study characterizes early SARS-CoV-2 viral RNA load in individuals with incident infections in association with COVID-19 symptom onset and severity.
has active quiz
JAMA Netw Open. 2022;5(1):e2142796. doi:10.1001/jamanetworkopen.2021.42796
HEALTH POLICY
Tarsicio Uribe-Leitz, MD, MPH; Bridget Matsas, BS; Michael K. Dalton, MD, MPH; et al.
This cross-sectional study uses geospatial analysis to identify medical facilities that present opportunities for military-civilian partnership in obstetric care and assess whether expanded use of military medical treatment facilities could improve access to emergency cesarean delivery care.
JAMA Netw Open. 2022;5(1):e2142835. doi:10.1001/jamanetworkopen.2021.42835
SUBSTANCE USE AND ADDICTION
Maryann Mason, PhD; Rebekah Soliman; Howard S. Kim, MD, MS; et al.
This cross-sectional study identifies potential divergences by race and ethnicity and by sex among older US adults who died due to opioid overdose.
JAMA Netw Open. 2022;5(1):e2142982. doi:10.1001/jamanetworkopen.2021.42982
ORTHOPEDICS
Martin H. Thornhill, MBBS, BDS, PhD; Annabel Crum, BSc; Saleema Rex, BA, MSc; et al.
This cohort assesses whether there is a temporal association between invasive dental procedures and subsequent later prosthetic joint infection among patients in England.
JAMA Netw Open. 2022;5(1):e2142987. doi:10.1001/jamanetworkopen.2021.42987
PEDIATRICS
Grace F. Ye, MD; Priyanka Thatipamala, MD; Michael Siegel, MD, MPH
This survey study examines the association of having children in the home and attitudes and beliefs about firearms among US gun owners.
JAMA Netw Open. 2022;5(1):e2142995. doi:10.1001/jamanetworkopen.2021.42995
CARDIOLOGY
Alexander R. Zheutlin, MD, MS; Favel L. Mondesir, PhD, MSPH; Catherine G. Derington, PharmD, MS; et al.
This cross-sectional study examines whether racial and ethnic differences were present for therapeutic inertia among participants in the Systolic Blood Pressure Intervention Trial.
JAMA Netw Open. 2022;5(1):e2143001. doi:10.1001/jamanetworkopen.2021.43001
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Invited Commentary
Therapeutic Inertia and Racial Differences in Blood Pressure Control鈥擳ime to Get Moving
Matthew B. Rivara, MD; Nisha Bansal, MD, MS; Bessie Young, MD, MPH
JAMA Netw Open
SUBSTANCE USE AND ADDICTION
James Wilton, MPH; Stanley Wong, MSc; Roy Purssell, MD; et al.
This cohort study examines the incidence of hepatitis C seroconversion in individuals prescribed opioid therapy for noncancer pain.
JAMA Netw Open. 2022;5(1):e2143050. doi:10.1001/jamanetworkopen.2021.43050
NUTRITION, OBESITY, AND EXERCISE
Bradley P. Turnwald, PhD; Kathryn G. Anderson, BA; Hazel Rose Markus, PhD; et al.
This cross-sectional study quantifies the nutritional quality of foods and beverages posted on social media accounts of highly followed celebrities and assesses the association of nutritional quality with post sponsorship, celebrity profession and sex, and followers鈥 likes and comments.
JAMA Netw Open. 2022;5(1):e2143087. doi:10.1001/jamanetworkopen.2021.43087
OTOLARYNGOLOGY
Rance J. T. Fujiwara, MD, MBA; Gail Ishiyama, MD; Akira Ishiyama, MD
This cross-sectional study investigates the association of sociodemographic, geographic, and parental characteristics with delayed cochlear implantation among children in California.
JAMA Netw Open. 2022;5(1):e2143132. doi:10.1001/jamanetworkopen.2021.43132
PEDIATRICS
Joel G. Ray, MD, MSc; Peter C. Austin, PhD; Kayvan Aflaki, HBSc; et al.
This cohort study evaluates the risk of self-harm and overdose among adolescents and young adults during vs before the COVID-19 pandemic.
has active quiz
JAMA Netw Open. 2022;5(1):e2143144. doi:10.1001/jamanetworkopen.2021.43144
PSYCHIATRY
Daniel T. Myran, MD, MPH; Nathan Cantor, MSc; Emily Rhodes, MSc; et al.
This cohort study examines the levels of mental health and substance use visits by physicians during the COVID-19 pandemic.
has active quiz
JAMA Netw Open. 2022;5(1):e2143160. doi:10.1001/jamanetworkopen.2021.43160
HEALTH POLICY
Paul R. Shafer, PhD; Katherine M. Gutiérrez, MA; Stephanie Ettinger de Cuba, PhD, MPH; et al.
This cross-sectional study uses data from the Household Pulse Survey to assess whether the introduction of advance payments for the Child Tax Credit in mid-July 2021 was associated with changes in food insufficiency in US households with children.
JAMA Netw Open. 2022;5(1):e2143296. doi:10.1001/jamanetworkopen.2021.43296
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Invited Commentary
Income Support as a Health Intervention
Heather D. Hill, MPP, PhD; Ali Rowhani-Rahbar, MPH, MD, PhD
JAMA Netw Open
MEDICAL EDUCATION
Lala L. Forrest, BS; Brooks P. Leitner, BS; Cirila Estela Vasquez Guzman, PhD; et al.
This cross-sectional study examines the representation of American Indian and Alaska Native individuals through the academic stages of medical training and proposes a framework that may be used to enhance diversification efforts.
JAMA Netw Open. 2022;5(1):e2143398. doi:10.1001/jamanetworkopen.2021.43398
INFECTIOUS DISEASES
Martha P. Montgomery, MD, MHS; Kai Hong, PhD; Kristie E. N. Clarke, MD; et al.
This cross-sectional study uses data from more than 800 hospitals to compare COVID-19 hospitalizations for people experiencing incarceration or homelessness with COVID-19 hospitalizations among the general population.
has active quiz
JAMA Netw Open. 2022;5(1):e2143407. doi:10.1001/jamanetworkopen.2021.43407
EMERGENCY MEDICINE
Raoul Daoust, MD, MSc; Jean Paquet, PhD; Martin Marquis, MSc; et al.
This meta-analysis reviews and analyzes the evidence regarding interventions to reduce the opioid prescribing rate or quantity for treating pain in patients discharged from the emergency department.
JAMA Netw Open. 2022;5(1):e2143425. doi:10.1001/jamanetworkopen.2021.43425
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Invited Commentary
Optimizing Opioid Prescriptions for Patients in the Emergency Department鈥擧ow Much Is Almost Never?
Austin S. Kilaru, MD, MSHP; Margaret Lowenstein, MD, MPhil; Anish K. Agarwal, MD, MPH
JAMA Netw Open
PUBLIC HEALTH
Ryan Suk, PhD, MS; Young-Rock Hong, PhD, MPH; Suja S. Rajan, PhD, MHA, MS; et al.
This cross-sectional study assesses the rates of US Preventive Services Task Force guideline鈥揷oncordant cervical cancer screening in the US from 2005 to 2019 and examines the sociodemographic factors associated with women鈥檚 self-reported reasons for not receiving up-to-date screening.
JAMA Netw Open. 2022;5(1):e2143582. doi:10.1001/jamanetworkopen.2021.43582
HEALTH POLICY
Natalie S. Lee, MD, MPH, MSHP; Rebecca Anastos-Wallen, MD; Krisda H. Chaiyachati, MD, MPH, MSHP; et al.
This cohort study uses data from a randomized clinical trial to assess the range of clinician responses to elevated blood pressure alerts via the electronic health record for patients receiving hypertension telemonitoring.
JAMA Netw Open. 2022;5(1):e2143590. doi:10.1001/jamanetworkopen.2021.43590
DIABETES AND ENDOCRINOLOGY
Shaheen Shiraz Kurani, PhD, ScM; Herbert C. Heien, MS; Lindsey R. Sangaralingham, MPH; et al.
This cohort study examines the geographically based risk factors for emergency department visits and hospitalizations associated with severe hypoglycemia and diabetic ketoacidosis or hyperglycemic hyperosmolar state in insured individuals with diabetes.
JAMA Netw Open. 2022;5(1):e2143597. doi:10.1001/jamanetworkopen.2021.43597
OBSTETRICS AND GYNECOLOGY
Sharmila Brabaharan, BPharm; Sajesh K. Veettil, PhD; Jennifer E. Kaiser, MD, MSCI; et al.
This umbrella review assesses evidence from meta-analyses of randomized clinical trials and cohort studies examining the association between hormonal contraceptive use and adverse health outcomes among women.
JAMA Netw Open. 2022;5(1):e2143730. doi:10.1001/jamanetworkopen.2021.43730
OPHTHALMOLOGY
Kai Yip Choi, PhD; Rachel Ka Man Chun, PhD; Wing Chun Tang, PhD; et al.
This cohort study analyzes the association of COVID-19鈥搑elated lockdown measures with myopia progression in schoolchildren using data from 2 independent longitudinal studies and compares the performance of defocus incorporated multiple segments lens with single vision lens in reducing myopia progression.
has active quiz
JAMA Netw Open. 2022;5(1):e2143781. doi:10.1001/jamanetworkopen.2021.43781
PSYCHIATRY
Ängla Mantel, MD, PhD; Anne K. Örtqvist, MD, PhD; Angelica Lindén Hirschberg, MD, PhD; et al.
This cohort study investigates the association between maternal eating disorders and risk of neurodevelopmental disorders in children of mothers with eating disorders using large-scale population-based Swedish health care registers.
JAMA Netw Open. 2022;5(1):e2143947. doi:10.1001/jamanetworkopen.2021.43947
PUBLIC HEALTH
Julia W. Haas, PhD; Friederike L. Bender, MS; Sarah Ballou, PhD; et al.
This systematic review and meta-analysis investigates the frequency of adverse events in placebo groups compared with that in vaccine groups in COVID-19 vaccine trials.
has active quiz
JAMA Netw Open. 2022;5(1):e2143955. doi:10.1001/jamanetworkopen.2021.43955
ONCOLOGY
Vipin Thampi, MPH; Roopa Hariprasad, DGO; Amrita John, MPH; et al.
This cross-sectional study examines the use of community health workers to perform screening of individuals for the presence of oral cancer in India.
JAMA Netw Open. 2022;5(1):e2144022. doi:10.1001/jamanetworkopen.2021.44022
ONCOLOGY
Kosj Yamoah, MD, PhD; Kyung Min Lee, PhD; Shivanshu Awasthi, PharmD, MPH; et al.
This cohort study assesses the extent of racial and ethnic disparities in the incidence, clinical stage, and outcomes of prostate cancer among African American and White men treated in the Veterans Affairs health care system.
JAMA Netw Open. 2022;5(1):e2144027. doi:10.1001/jamanetworkopen.2021.44027
NEUROLOGY
Marie-Jeanne Buscot, PhD; Ronil V. Chandra, MBBS; Julian Maingard, MBBS; et al.
This cohort study of patients with aneurysmal subarachnoid hemorrhage assesses the associations between onset-to-treatment time and postsurgical outcomes.
JAMA Netw Open. 2022;5(1):e2144039. doi:10.1001/jamanetworkopen.2021.44039
CRITICAL CARE MEDICINE
Christopher E. Cox, MD, MPH; Deepshikha Charan Ashana, MD, MBA, MS; Krista L. Haines, DO; et al.
This cohort study assesses whether higher levels of family member鈥搑eported palliative care needs are observed among those whose critically ill loved ones meet a clinical palliative care trigger compared with those who do not meet such a trigger.
JAMA Netw Open. 2022;5(1):e2144093. doi:10.1001/jamanetworkopen.2021.44093
ONCOLOGY
Satya Das, MD, MSCI; Aman Chauhan, MD; Liping Du, PhD; et al.
This cohort study examines a clinical score鈥檚 ability to estimate the benefit from peptide receptor radionuclide therapy for individual patients with well-differentiated neuroendocrine tumors.
JAMA Netw Open. 2022;5(1):e2144170. doi:10.1001/jamanetworkopen.2021.44170
NEUROLOGY
Jean K. Mah, MD; Paula R. Clemens, MD; Michela Guglieri, MD; et al.
This nonrandomized controlled trial examines efficacy of vamorolone treatment for Duchenne muscular dystrophy among boys compared with glucocorticoid treatment.
JAMA Netw Open. 2022;5(1):e2144178. doi:10.1001/jamanetworkopen.2021.44178
GLOBAL HEALTH
Ningjing Chen, MMed; Daniel Yee Tak Fong, PhD; Janet Yuen Ha Wong, PhD
This cross-sectional analysis evaluates secular trends in global musculoskeletal rehabilitation needs by sex, age, region, country, and health condition.
JAMA Netw Open. 2022;5(1):e2144198. doi:10.1001/jamanetworkopen.2021.44198
DIVERSITY, EQUITY, AND INCLUSION
Cindy V. Valencia, PhD; Melanie Dove, ScD; Elisa K. Tong, MD
This cross-sectional study uses the California Health Interview Survey to investigate disparities in receipt of smoking cessation advice and assistance between Latino and non-Latino White smokers.
JAMA Netw Open. 2022;5(1):e2144207. doi:10.1001/jamanetworkopen.2021.44207
PUBLIC HEALTH
Joseph Burzynski, MD, MPH; Joan M. Mangan, MST, PhD; Chee Kin Lam, MS, MPH; et al.
This randomized noninferiority trial compares the effectiveness of electronic directly observed therapy for tuberculosis treatment regimen with in-person observation.
JAMA Netw Open. 2022;5(1):e2144210. doi:10.1001/jamanetworkopen.2021.44210
PEDIATRICS
David J. Inwards-Breland, MD, MPH; Nicole E. Johns, MPH; Anita Raj, PhD
This survey study assesses sexual violence associated with sexual identity and gender among lesbian, gay, bisexual, queer, asexual, and other sexual identities (LGBQA+) adults reporting their experiences as adolescents and young adults.
JAMA Netw Open. 2022;5(1):e2144266. doi:10.1001/jamanetworkopen.2021.44266
NUTRITION, OBESITY, AND EXERCISE
Sophia Liu, PhD; Davide D鈥橝mico, PhD; Eric Shankland, PhD; et al.
This randomized clinical trial evaluates the improvement in the 6-minute walk distance test and in leg and hand muscle endurance after use of urolithin A in patients aged 65 to 90 years.
JAMA Netw Open. 2022;5(1):e2144279. doi:10.1001/jamanetworkopen.2021.44279
OBSTETRICS AND GYNECOLOGY
Carolyn Sufrin, MD, PhD; Camille T. Kramer, MPH; Mishka Terplan, MD, MPH; et al.
This cross-sectional study uses verified data from the National Jail Compendium to assess the availability of medication for the treatment of opioid use disorder among pregnant individuals incarcerated in US jails.
JAMA Netw Open. 2022;5(1):e2144369. doi:10.1001/jamanetworkopen.2021.44369
PSYCHIATRY
Matthew K. Nock, PhD; Alexander J. Millner, PhD; Eric L. Ross, MD; et al.
This prognostic study assesses methods of identifying patients at high risk of suicide attempts within 1 and 6 months after patients presented at an emergency department for psychiatric problems using clinician assessments, a brief patient self-report scale, and electronic health records.
JAMA Netw Open. 2022;5(1):e2144373. doi:10.1001/jamanetworkopen.2021.44373
ONCOLOGY
Caryn E. S. Oshiro, PhD, RD; Timothy B. Frankland, MA; Joanne Mor, MS; et al.
This cohort study examines racial and ethnic differences in lung cancer screening completion and follow-up rates in a multiethnic population in Hawaii.
JAMA Netw Open. 2022;5(1):e2144381. doi:10.1001/jamanetworkopen.2021.44381
HEALTH POLICY
Ameet Sarpatwari, PhD, JD; Beatrice L. Brown, MBE; Sarah A. McGraw, PhD; et al.
This qualitative study examines patient and caregiver experiences with and perceptions of Risk Evaluation and Mitigation Strategy programs with Elements to Assure Safe Use.
JAMA Netw Open. 2022;5(1):e2144386. doi:10.1001/jamanetworkopen.2021.44386
OBSTETRICS AND GYNECOLOGY
Madhavi Thombre Kulkarni, MS, PhD; Amy Shafrir, ScD; Leslie V. Farland, ScD; et al.
This cohort study investigates the association of endometriosis and risk of early menopause, adjusting for assesses the anthropometric, behavioral, and reproductive factors, among premenopausal female nurses in the Nurses鈥 Health Study II cohort.
JAMA Netw Open. 2022;5(1):e2144391. doi:10.1001/jamanetworkopen.2021.44391
PUBLIC HEALTH
Tasleem J. Padamsee, PhD; Robert M. Bond, PhD; Graham N. Dixon, PhD; et al.
This survey study compares changes in COVID-19 vaccine hesitancy between Black and White individuals in the US and examines mechanisms that might help explain the observed differences.
has active quiz
JAMA Netw Open. 2022;5(1):e2144470. doi:10.1001/jamanetworkopen.2021.44470
HEALTH POLICY
Gordon D. Schiff, MD; Mayya Volodarskaya, MD; Elise Ruan, MD, MPH; et al.
This qualitative study develops the construct and collects examples of diagnostic pitfalls, defined as clinical situations and scenarios vulnerable to errors that may lead to missed, delayed, or wrong diagnoses.
JAMA Netw Open. 2022;5(1):e2144531. doi:10.1001/jamanetworkopen.2021.44531
NEPHROLOGY
Marcello Tonelli, MD, SM, MSc; Anita Lloyd, MSc; Winson Y. Cheung, MD, MPH; et al.
This cohort study compares the clinical consequences of incident severe chronic kidney disease (CKD) and the first diagnosis of a malignant tumor among men and women residing in Canada.
JAMA Netw Open. 2022;5(1):e2144713. doi:10.1001/jamanetworkopen.2021.44713
PEDIATRICS
Nicole R. van Veenendaal, MD, MSc; Sophie R. D. van der Schoor, MD, PhD; Birit F. P. Broekman, MD, PhD; et al.
This cohort study examines the association of a family integrated care model vs standard neonatal care with mental health outcomes among fathers of preterm neonates.
JAMA Netw Open. 2022;5(1):e2144720. doi:10.1001/jamanetworkopen.2021.44720
PEDIATRICS
Alva Tang, PhD; Nathan A. Fox, PhD; Natalie Slopen, ScD
This cohort study examines whether a childhood temperament characterized by shyness and avoidance of social interactions is associated with poor cardiometabolic health.
JAMA Netw Open. 2022;5(1):e2144727. doi:10.1001/jamanetworkopen.2021.44727
HEALTH INFORMATICS
Feyisope R. Eweje, SB; Suzie Byun, SB; Rajat Chandra, BS; et al.
This cohort study examines the translatability of findings from studies on artificial intelligence funded by the National Institutes of Health (NIH).
JAMA Netw Open. 2022;5(1):e2144742. doi:10.1001/jamanetworkopen.2021.44742
NEUROLOGY
Kerstin Hellwig, MD; Marianne Tokic, MSc; Sandra Thiel, PhD; et al.
This cohort study examines the associations between cessation of natalizumab therapy in women with multiple sclerosis before or during the first trimester of pregnancy with relapse occurrence and relapse-related disability.
JAMA Netw Open. 2022;5(1):e2144750. doi:10.1001/jamanetworkopen.2021.44750
PSYCHIATRY
E. Kate Webb, PhD; Claire M. Bird, MS; Terri A. deRoon-Cassini, PhD; et al.
This cross-sectional study examines the association of racial discrimination and the connectivity of salience network nodes to offer insight into the association between racism and adverse health outcomes.
JAMA Netw Open. 2022;5(1):e2144759. doi:10.1001/jamanetworkopen.2021.44759
ETHICS
David Grande, MD, MPA; Nandita Mitra, PhD; Raghuram Iyengar, PhD; et al.
This survey study evaluates the factors associated with consumers鈥 willingness to share their digital health information for research, health care, and commercial uses.
JAMA Netw Open. 2022;5(1):e2144787. doi:10.1001/jamanetworkopen.2021.44787
ONCOLOGY
Aakash Desai, MBBS, MPH; Caleb Scheckel, DO; Chelsee J. Jensen, PharmD, RPh; et al.
This cross-sectional study examines trends in costs of brand-name medications for treatment of non鈥搒mall cell lung cancer and within-class price differences between these medications in the US from 2015 to 2020.
JAMA Netw Open. 2022;5(1):e2144923. doi:10.1001/jamanetworkopen.2021.44923
SUBSTANCE USE AND ADDICTION
Kathryn Hawk, MD, MPH; Ryan McCormack, MD; E. Jennifer Edelman, MD; et al.
This qualitative study assesses the experiences and perspectives of individuals with untreated opioid use disorder seen in emergency departments (EDs) in 5 regions of the US.
JAMA Netw Open. 2022;5(1):e2144955. doi:10.1001/jamanetworkopen.2021.44955
HEALTH POLICY
Gracie Himmelstein, MD; David Bates, MD, MS; Li Zhou, MD, PhD
This cross-sectional study analyzes the prevalence of stigmatizing language in the electronic health records at a large academic medical center.
JAMA Netw Open. 2022;5(1):e2144967. doi:10.1001/jamanetworkopen.2021.44967
MEDICAL EDUCATION
David A. Cook, MD, MHPE; Christopher R. Stephenson, MD; John M. Wilkinson, MD; et al.
This systematic review of 38 studies assesses the association between the costs of physician continuous professional development and drug costs related to prescribing.
JAMA Netw Open. 2022;5(1):e2144973. doi:10.1001/jamanetworkopen.2021.44973
CARDIOLOGY
Jason E. Bloom, MBBS; Emily Andrew, MBiostats; Luke P. Dawson, MBBS, MPH; et al.
This population-based cohort study assesses the incidence, etiology, and clinical outcomes of patients with nontraumatic shock treated by emergency medical services (EMS) in Victoria, Australia.
JAMA Netw Open. 2022;5(1):e2145179. doi:10.1001/jamanetworkopen.2021.45179
SURGERY
Shivanthe Sivanesan, MD; Kristin Austlid Taskén, PhD; Helene Hartvedt Grytli, PhD
This cohort study of men who have undergone radical prostatectomy assesses the association between incidental nonselective 尾-blocker use and treatment for prostate cancer recurrence.
JAMA Netw Open. 2022;5(1):e2145230. doi:10.1001/jamanetworkopen.2021.45230
PHARMACY AND CLINICAL PHARMACOLOGY
Katherine E. Di Palo, PharmD; Mark J. Sinnett, PharmD; Pavel Goriacko, PharmD, MPH
This cohort study analyzes outcomes associated with the use of patiromer as monotherapy for non鈥搇ife-threatening hyperkalemia in adult patients in an acute care setting.
JAMA Netw Open. 2022;5(1):e2145236. doi:10.1001/jamanetworkopen.2021.45236
OCCUPATIONAL HEALTH
Matthew D. Kearney, PhD, MPH; Frances K. Barg, PhD, MEd; Dominique Alexis, BS; et al.
This qualitative study aims to identify and characterize the reported health and well-being outcomes associated with perceived discrimination among academic medicine faculty, staff, and students.
JAMA Netw Open. 2022;5(1):e2145243. doi:10.1001/jamanetworkopen.2021.45243
PSYCHIATRY
Emerson M. Wickwire, PhD; Jennifer S. Albrecht, PhD; Vincent F. Capaldi II, MD, MSc; et al.
This cohort study of 2022 adults with traumatic brain injury identifies unique trajectories of insomnia during the 12 months after injury based on serial assessment using standardized measures.
JAMA Netw Open. 2022;5(1):e2145310. doi:10.1001/jamanetworkopen.2021.45310
GERIATRICS
Zachary A. Marcum, PharmD, PhD; Jordana B. Cohen, MD, MSCE; Chong Zhang, MS; et al.
This secondary analysis cohort study of Systolic Blood Pressure Intervention Trial (SPRINT) participants assesses the association between antihypertensive medications that stimulate type 2 and 4 angiotensin II receptors with the risk of incident cognitive impairment.
JAMA Netw Open. 2022;5(1):e2145319. doi:10.1001/jamanetworkopen.2021.45319
ONCOLOGY
Douglas W. Blayney, MD; Ramon Mohanlal, MD, PhD; Hryhoriy Adamchuk, MD; et al.
This randomized clinical trial compares the efficacy of plinabulin vs pegfilgrastim to prevent severe neutropenia in patients receiving docetaxel myelosuppressive chemotherapy.
JAMA Netw Open. 2022;5(1):e2145446. doi:10.1001/jamanetworkopen.2021.45446
ONCOLOGY
Yuki Takumoto, BS; Yuriko Sasahara, MD, PhD; Hiroto Narimatsu, MD, PhD; et al.
This systematic review and network meta-analysis compares the short-term and long-term outcomes associated with first-line chemotherapy regiments used in Japan for patients with metastatic pancreatic cancer.
JAMA Netw Open. 2022;5(1):e2145515. doi:10.1001/jamanetworkopen.2021.45515
OBSTETRICS AND GYNECOLOGY
Greg Marchand, MD; Ahmed Taher Masoud, MD; Malini Govindan, MD; et al.
This systematic review and meta-analysis compares adverse neonatal outcomes among mothers exposed to marijuana during pregnancy vs mothers not exposed to marijuana during pregnancy in 16 cohort studies.
JAMA Netw Open. 2022;5(1):e2145653. doi:10.1001/jamanetworkopen.2021.45653
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Invited Commentary
Reexamining Risks of Prenatal Cannabis Use鈥擬ounting Evidence and a Call to Action
Kara R. Skelton, PhD; Sara E. Benjamin-Neelon, PhD, JD, MPH
JAMA Netw Open
INFECTIOUS DISEASES
Douglas M. Heithoff, PhD; Lucien Barnes V, PhD; Scott P. Mahan, BS; et al.
This cohort study examines whether a smartphone-based loop-mediated isothermal amplification (LAMP) assay is suitable for SARS-CoV-2 and influenza virus testing without requiring specialized equipment, accessory devices, or custom reagents.
has active quiz
JAMA Netw Open. 2022;5(1):e2145669. doi:10.1001/jamanetworkopen.2021.45669
PSYCHIATRY
Alisa B. Busch, MD, MS; Haiden A. Huskamp, PhD; Pushpa Raja, MD, MSHPM; et al.
This cohort study examines changes in mental health care during the pandemic and the use of telemedicine in outpatient care among Medicare beneficiaries with severe mental illness.
has active quiz
JAMA Netw Open. 2022;5(1):e2145677. doi:10.1001/jamanetworkopen.2021.45677
SUBSTANCE USE AND ADDICTION
Scott G. Weiner, MD, MPH; Sanae El Ibrahimi, PhD; Michelle A. Hendricks, PhD; et al.
This cohort study investigates patient- and prescription-related factors associated with opioid-related fatal or nonfatal overdose among opioid-naive individuals receiving an initial opioid prescription.
JAMA Netw Open. 2022;5(1):e2145691. doi:10.1001/jamanetworkopen.2021.45691
PUBLIC HEALTH
Roy H. Perlis, MD, MSc; Katherine Ognyanova, PhD; Mauricio Santillana, PhD; et al.
This survey study examines the association of moderate or greater depressive symptoms with believing COVID-19 vaccine鈥搑elated misinformation.
has active quiz
JAMA Netw Open. 2022;5(1):e2145697. doi:10.1001/jamanetworkopen.2021.45697
OPHTHALMOLOGY
Saurabh Jain, MBBS; Peng Yong Sim, MBChB(Hons); Joanne Beckmann, MBBS, MSc; et al.
This birth cohort study evaluates visual function and ocular morbidity in young adults born extremely preterm compared with controls born full term.
JAMA Netw Open. 2022;5(1):e2145702. doi:10.1001/jamanetworkopen.2021.45702
PSYCHIATRY
Linghua Kong, PhD; Xinxia Chen, PhD; Yajun Liang, PhD; et al.
This cohort study uses data from national registers in Finland to examine the association between exposure to maternal preeclampsia, alone and together with exposure to perinatal complications, and the risk of neurodevelopmental and psychiatric disorders in offspring.
JAMA Netw Open. 2022;5(1):e2145719. doi:10.1001/jamanetworkopen.2021.45719
SURGERY
Adam Gutierrez, MD; Kazuhide Matsushima, MD; Areg Grigorian, MD; et al.
This cohort study analyzes data from the American College of Surgeons Trauma Quality Improvement Program database to develop and validate a model to identify patients requiring early laparotomy following trauma.
JAMA Netw Open. 2022;5(1):e2145860. doi:10.1001/jamanetworkopen.2021.45860
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Invited Commentary
Clinical Prediction Tools in Trauma: Where Do We Go From Here?
Jeff Choi, MD, MSc; Joseph D. Forrester, MD, MSc
JAMA Netw Open
PSYCHIATRY
Masahide Koda, PhD; Nahoko Harada, PhD; Akifumi Eguchi, PhD; et al.
This cross-sectional study assesses whether the COVID-19 pandemic was associated with changes in reasons for suicide among individuals in Japan.
has active quiz
JAMA Netw Open. 2022;5(1):e2145870. doi:10.1001/jamanetworkopen.2021.45870
ANESTHESIOLOGY
To-Nhu Vu, MD; Chachrit Khunsriraksakul, BS; Yakov Vorobeychik, MD, PhD; et al.
This cohort study examines the association between spinal cord stimulation treatment and long-term opioid therapy among patients with postlaminectomy syndrome (PLS).
JAMA Netw Open. 2022;5(1):e2145876. doi:10.1001/jamanetworkopen.2021.45876
DIABETES AND ENDOCRINOLOGY
Yujie Liu, MBBS; Tingting Geng, PhD; Zhenzhen Wan, MPH; et al.
This cohort study uses data from a nationally representative sample of US adults to assess whether serum folate or vitamin B12 levels are associated with the risk of cardiovascular disease mortality among individuals with type 2 diabetes.
JAMA Netw Open. 2022;5(1):e2146124. doi:10.1001/jamanetworkopen.2021.46124
GERIATRICS
Marla K. Beauchamp, PhD; Divya Joshi, PhD; Jacqueline McMillan, MD; et al.
This cohort study evaluates the association of mild to moderate COVID-19 with change in mobility and physical function in a population-based sample of adults aged 50 years or older in Canada.
has active quiz
JAMA Netw Open. 2022;5(1):e2146168. doi:10.1001/jamanetworkopen.2021.46168
NEUROLOGY
Neil Watson, MD; Peter Hermann, MD; Anna Ladogana, MD; et al.
This diagnostic study assesses the accuracy of revised guidelines for the diagnosis of Creutzfeldt-Jakob disease using autopsy-confirmed results from surveillance centers in France, Germany, Italy, and the United Kingdom.
JAMA Netw Open. 2022;5(1):e2146319. doi:10.1001/jamanetworkopen.2021.46319
INFECTIOUS DISEASES
Andrea B. Troxel, ScD; Eva Petkova, PhD; Keith Goldfeld, DrPH; et al.
This meta-analysis examines individual patient data from 8 randomized clinical trials of COVID-19 convalescent plasma to determine its safety and efficacy in treating hospitalized patients with COVID-19.
has active quiz
JAMA Netw Open. 2022;5(1):e2147331. doi:10.1001/jamanetworkopen.2021.47331
INFECTIOUS DISEASES
Hyung Park, PhD; Thaddeus Tarpey, PhD; Mengling Liu, PhD; et al.
This prognostic study develops an index for predicting the expected relative COVID-19 convalescent plasma treatment benefit for patients hospitalized for COVID-19 using patients鈥 baseline characteristics.
has active quiz
JAMA Netw Open. 2022;5(1):e2147375. doi:10.1001/jamanetworkopen.2021.47375