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October 2024 - April 2015

Decade

Year

Issue

April 2023, Vol 9, No. 4, Pages 449-576

Original Investigation

Estimates and Projections of the Global Economic Cost of 29 Cancers in 204 Countries and Territories From 2020 to 2050

Abstract Full Text
open access
JAMA Oncol. 2023;9(4):465-472. doi:10.1001/jamaoncol.2022.7826

This decision analytical model study estimates the macroeconomic cost of 29 cancers in 204 countries and territories.

Breast Cancer Diagnosis, Treatment, and Outcomes of Patients From Sex and Gender Minority Groups

Abstract Full Text
free access
JAMA Oncol. 2023;9(4):473-480. doi:10.1001/jamaoncol.2022.7146

This case-control study investigates the quality of breast cancer treatment and recurrence outcomes for patients from sex and gender minority groups compared with cisgender heterosexual patients.

Association of Radiation and Procarbazine Dose With Risk of Colorectal Cancer Among Survivors of Hodgkin Lymphoma

Abstract Full Text
open access
JAMA Oncol. 2023;9(4):481-489. doi:10.1001/jamaoncol.2022.7153

This nested case-control study of 5-year Hodgkin lymphoma survivors explores dose-response associations of radiation therapy and procarbazine with colorectal cancer.

Prognostic and Predictive Value of Immune-Related Gene Expression Signatures vs Tumor-Infiltrating Lymphocytes in Early-Stage ERBB2/HER2-Positive Breast Cancer: A Correlative Analysis of the CALGB 40601 and PAMELA Trials

Abstract Full Text
open access
JAMA Oncol. 2023;9(4):490-499. doi:10.1001/jamaoncol.2022.6288

This prognostic study (in which a combined correlative analysis of the CALGB 40601 and PAMELA trials was conducted) compares the effectiveness of tumor-infiltrating lymphocytes vs immune-related gene expression signatures in predicting pathologic complete response and event-free survival in patients with early-stage ERBB2/HER2-positive breast cancer.

Clinicopathologic Characteristics and Prognosis of ERBB2-Low Breast Cancer Among Patients in the National Cancer Database

Abstract Full Text
open access
JAMA Oncol. 2023;9(4):500-510. doi:10.1001/jamaoncol.2022.7476

This cohort study uses National Cancer Database data to investigate whether breast cancer with low ERBB2 expression is a clinically distinct subtype compared with breast cancer with no ERBB2 expression, with distinct epidemiological characteristics, prognosis, and response to neoadjuvant chemotherapy.

Hyaluronic Acid Spacer for Hypofractionated Prostate Radiation Therapy: A Randomized Clinical Trial

Abstract Full Text
open access
JAMA Oncol. 2023;9(4):511-518. doi:10.1001/jamaoncol.2022.7592

This randomized clinical trial examines whether a hyaluronic acid rectal spacer could improve rectal dosimetry and affect acute grade 2 or higher gastrointestinal toxic effects for hypofractionated radiation therapy.

Allogeneic Hematopoietic Cell Transplantation vs Standard Consolidation Chemotherapy in Patients With Intermediate-Risk Acute Myeloid Leukemia: A Randomized Clinical Trial

Abstract Full Text
free access
JAMA Oncol. 2023;9(4):519-526. doi:10.1001/jamaoncol.2022.7605

This randomized clinical trial of adults with intermediate-risk acute myeloid leukemia explores the optimal therapy for these patients after complete remission.

Association of Immune-Related Adverse Events With Efficacy of Atezolizumab in Patients With Non–Small Cell Lung Cancer: Pooled Analyses of the Phase 3 IMpower130, IMpower132, and IMpower150 Randomized Clinical Trials

Abstract Full Text
open access
JAMA Oncol. 2023;9(4):527-535. doi:10.1001/jamaoncol.2022.7711

This analysis of pooled data from 3 randomized clinical trials evaluates the association between immune-related adverse events and atezolizumab efficacy in patients with advanced non–small cell lung cancer.

Association of Social Determinants and Tumor Biology With Racial Disparity in Survival From Early-Stage, Hormone-Dependent Breast Cancer

Abstract Full Text
free access
JAMA Oncol. 2023;9(4):536-545. doi:10.1001/jamaoncol.2022.7705

This retrospective mediation analysis examines the proportion of the Black-White disparity in breast cancer survival from estrogen receptor–positive, axillary node-negative breast cancer that is mediated by adverse social determinants and high-risk tumor biology.

Brief Report

Impact of Common Vitamin D–Binding Protein Isoforms on Supplemental Vitamin D3 and/or Calcium Effects on Colorectal Adenoma Recurrence Risk: A Secondary Analysis of a Randomized Clinical Trial

Abstract Full Text
free access
JAMA Oncol. 2023;9(4):546-551. doi:10.1001/jamaoncol.2022.6924

This secondary analysis of a randomized clinical trial assesses whether GC gene missense variants encoding common vitamin D–binding protein isoforms modify the effects of vitamin D3 and/or calcium supplementation on colorectal adenoma recurrence risk.

Cardiovascular Magnetic Resonance Imaging in Patients With Ibrutinib-Associated Cardiotoxicity

Abstract Full Text
free access
JAMA Oncol. 2023;9(4):552-555. doi:10.1001/jamaoncol.2022.6869

This cohort study of consecutive patients imaged with cardiac magnetic resonance imaging examines the prevelance of ibrutinib-associated cardiotoxic effects.

Research Letter

Assessment of Phase 3 Randomized Clinical Trials Including Patients With Leptomeningeal Disease: A Systematic Review

Abstract Full Text
free access
JAMA Oncol. 2023;9(4):566-567. doi:10.1001/jamaoncol.2022.7364

This systematic review examines the proportion of patients with leptomeningeal disease included in phase 3 randomized clinical trials for patients with metastatic breast cancer, lung cancer, and melanoma.

Exposure to US Cancer Drugs With Lack of Confirmed Benefit After US Food and Drug Administration Accelerated Approval

Abstract Full Text
open access
JAMA Oncol. 2023;9(4):567-569. doi:10.1001/jamaoncol.2022.7770

This cross-sectional study evaluates patient exposure to oncology drugs withdrawn from the US Food and Drug Administration (FDA) Accelerated Approval program.

Review

Cancer in Transgender and Gender-Diverse Persons: A Review

Abstract Full Text
has active quiz
JAMA Oncol. 2023;9(4):556-563. doi:10.1001/jamaoncol.2022.7173

This narrative review examines primary and secondary prevention of cancer, barriers to health care services, and health care practitioners’ knowledge about specific issues pertaining to transgender and gender-diverse individuals.

JAMA Oncology Clinical Challenge

Worsening Rash in a Patient With Metastatic Breast Cancer

Abstract Full Text
has active quiz
JAMA Oncol. 2023;9(4):564-565. doi:10.1001/jamaoncol.2022.6895

A 56-year-old woman with metastatic hormone receptor–positive, ERBB2-negative breast cancer presents with pruritic, erythematous, scaly macules and papules on her forearms, faces, chest, and upper back. What is your diagnosis?

Viewpoint

Improving Diversity in Clinical Trials by Using Real-world Data to Define Eligibility Criteria

Abstract Full Text
JAMA Oncol. 2023;9(4):455-456. doi:10.1001/jamaoncol.2022.7170

This Viewpoint discusses the need for thoughtful, modernized eligibility criteria with equity prioritization in clinical trials.

Next-Generation Alternative Payment Models in Oncology—Will Precision Preclude Participation?

Abstract Full Text
JAMA Oncol. 2023;9(4):457-458. doi:10.1001/jamaoncol.2022.7179

This Viewpoint proposes 3 changes to the Enhancing Oncology Model of the US Centers for Medicare & Medicaid Services.

Omission of Critical Information From Clinical Trial Reports—What to Do About Uninterpretable Results

Abstract Full Text
JAMA Oncol. 2023;9(4):459-460. doi:10.1001/jamaoncol.2022.7182

This Viewpoint identifies incomplete and missing data in 3 clinical trials to highlight the need for improved data reporting and to propose possible solutions.

Editorial

The Global Economic Cost of Cancer—Estimating It Is Just the First Step!

Abstract Full Text
JAMA Oncol. 2023;9(4):461-462. doi:10.1001/jamaoncol.2022.7133

War and Siege Halt Gynecologic Oncology Services for Women in the Tigray Region of Ethiopia: A Call to Action

Abstract Full Text
JAMA Oncol. 2023;9(4):463-464. doi:10.1001/jamaoncol.2022.6106

This essay urges action in the aftermath of a war that destroyed the health care system, specifically women’s cervical cancer screening and treatment, in Tigray.

JAMA Oncology Patient Page

ERBB2-Low (Also Known as HER2-Low) Breast Cancer

Abstract Full Text
free access
JAMA Oncol. 2023;9(4):576. doi:10.1001/jamaoncol.2022.6889

This JAMA Oncology Patient Page discusses classification of breast cancer and ERBB2 status.

Comment & Response

Increased Tumor Mutation Burden Levels and Sensitivity of Non–Small Cell Lung Cancer to PD-L1 Blockade

Abstract Full Text
JAMA Oncol. 2023;9(4):569-570. doi:10.1001/jamaoncol.2022.7583

Increased Tumor Mutation Burden Levels and Sensitivity of Non–Small Cell Lung Cancer to PD-L1 Blockade

Abstract Full Text
JAMA Oncol. 2023;9(4):570. doi:10.1001/jamaoncol.2022.7586

Increased Tumor Mutation Burden Levels and Sensitivity of Non–Small Cell Lung Cancer to PD-L1 Blockade—Reply

Abstract Full Text
JAMA Oncol. 2023;9(4):570-571. doi:10.1001/jamaoncol.2022.7589

The MaxCombo Test Severely Violates the Type I Error Rate

Abstract Full Text
JAMA Oncol. 2023;9(4):571-572. doi:10.1001/jamaoncol.2022.7747

The MaxCombo Test Severely Violates the Type I Error Rate—Reply

Abstract Full Text
JAMA Oncol. 2023;9(4):572. doi:10.1001/jamaoncol.2022.7750

Sinoatrial Node Radiation Dose and Atrial Fibrillation in Patients With Lung Cancer

Abstract Full Text
JAMA Oncol. 2023;9(4):572-573. doi:10.1001/jamaoncol.2022.7872

Sinoatrial Node Radiation Dose and Atrial Fibrillation in Patients With Lung Cancer

Abstract Full Text
JAMA Oncol. 2023;9(4):573-574. doi:10.1001/jamaoncol.2022.7875

Sinoatrial Node Radiation Dose and Atrial Fibrillation in Patients With Lung Cancer—Reply

Abstract Full Text
JAMA Oncol. 2023;9(4):574. doi:10.1001/jamaoncol.2022.7878
Correction

Errors in Affiliation, Figure 3, and Supplement 4

Abstract Full Text
free access
JAMA Oncol. 2023;9(4):574. doi:10.1001/jamaoncol.2023.0822
JAMA Oncology Masthead

JAMA Oncology

Abstract Full Text
free access
JAMA Oncol. 2023;9(4):449. doi:10.1001/jamaoncol.2022.4852
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