Lindsay M. Morton, PhD; Graça M. Dores, MD, MPH; Sara J. Schonfeld, PhD, MPH; et al.
free access
JAMA Oncol. 2019;5(3):318-325. doi:10.1001/jamaoncol.2018.5625
This population-based study examines the incidence and risks for development of therapy-related myelodysplastic syndrome or acute myeloid leukemia (tMDS/AML) in patients who have received chemotherapy for primary solid cancers.
Joseph M. Unger, PhD; Dawn L. Hershman, MD; Mark E. Fleury, PhD; et al.
free access
has audio
JAMA Oncol. 2019;5(3):326-333. doi:10.1001/jamaoncol.2018.5953
This national survey study of patients with cancer evaluates the association between patient comorbid conditions and cancer clinical trial participation.
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Podcast:
Association of Patient Comorbid Conditions With Cancer Clinical Trial Participation
Sylvia Adams, MD; Jennifer R. Diamond, MD; Erika Hamilton, MD; et al.
free access
JAMA Oncol. 2019;5(3):334-342. doi:10.1001/jamaoncol.2018.5152
This phase 1b multicohort study assessed 33 patients with advanced triple-negative breast cancer treated with atezolizumab plus nab-paclitaxel to examine its safety, tolerability, and preliminary clinical activity.
Chiara Cremolini, MD, PhD; Daniele Rossini, MD; Emanuela Dell’Aquila, MD; et al.
free access
JAMA Oncol. 2019;5(3):343-350. doi:10.1001/jamaoncol.2018.5080
This multicenter, phase 2, single-arm trial assesses the activity of cetuximab plus irinotecan as third-line treatment for patients with RAS and BRAF wild-type metastatic colorectal cancer who were initially sensitive to and then resistant to first-line irinotecan- and cetuximab-based therapy.
Raffit Hassan, MD; Anish Thomas, MD; John J. Nemunaitis, MD; et al.
open access
JAMA Oncol. 2019;5(3):351-357. doi:10.1001/jamaoncol.2018.5428
This phase 1b clinical trial assesses the safety and efficacy of avelumab treatment in a multinational cohort of patients with unresectable, previously treated malignant mesothelioma.
Steven D. Criss, BS; Meghan J. Mooradian, MD; Deirdre F. Sheehan, MPH; et al.
free access
JAMA Oncol. 2019;5(3):358-365. doi:10.1001/jamaoncol.2018.5449
This study explores the cost-effectiveness and potential budgetary consequences of durvalumab consolidation therapy vs no consolidation therapy after chemoradiotherapy in stage III non–small cell lung cancer (NSCLC) in the context of the US health care system.
Michael F. Press, MD, PhD; Jose A. Seoane, PhD; Christina Curtis, PhD; et al.
open access
JAMA Oncol. 2019;5(3):366-375. doi:10.1001/jamaoncol.2018.6012
This study examines HER2 ISH-equivocal breast cancers to asses 2013/2014 American Society of Clinical Oncology and College of American Pathologists guidelines in determining HER2-positive or HER2-negative breast cancers and false-positive results.
Yukihiro Toi, MD; Shunichi Sugawara, MD, PhD; Jun Sugisaka, MD; et al.
free access
JAMA Oncol. 2019;5(3):376-383. doi:10.1001/jamaoncol.2018.5860
This medical records analysis from a single institution in Japan assesses anti–PD-1 treatment in patients with subclinical advanced non–small cell lung cancer and with or without preexisting autoimmune markers and evaluates potential clinical biomarkers that may be associated with clinical benefit or with immune-related adverse events.
Farhad Islami, MD, PhD; Ann Goding Sauer, MSPH; Susan M. Gapstur, PhD; et al.
free access
JAMA Oncol. 2019;5(3):384-392. doi:10.1001/jamaoncol.2018.5639
This cross-sectional study analyzes the proportion of cancer cases attributable to excess body weight in each US state using data from several databases.
Mary L. Disis, MD; Matthew H. Taylor, MD; Karen Kelly, MD; et al.
open access
JAMA Oncol. 2019;5(3):393-401. doi:10.1001/jamaoncol.2018.6258
This phase 1b open-label study assesses the efficacy and safety of avelumab, an anti–programmed death ligand 1 agent, in a cohort of patients with previously treated recurrent or refractory ovarian cancer.
Ahmed Salem, FRCR; Hitesh Mistry, PhD; Matthew Hatton, FRCR; et al.
open access
online only
JAMA Oncol. 2019;5(3):e185335. doi:10.1001/jamaoncol.2018.5335
This secondary analysis of a randomized clinical trial examines the association of modern chemoradiotherapy with survival among patients with stage I to II small cell lung cancer compared with that among patients with stage III small cell lung cancer.