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Research Letter
Aging and Health
August 12, 2024

Antiplatelet and Anticoagulant Use in Nursing Home Residents With Atrial Fibrillation

Author Affiliations
  • 1Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, and Harvard Medical School, Boston, Massachusetts
  • 2Department of Health Services, Policy, and Practice and Center for Gerontology, Brown University School of Public Health, Providence, Rhode Island
  • 3Center for Aging and Serious Illness, Division of General Internal Medicine, Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston
  • 4Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island
JAMA Intern Med. 2024;184(10):1256-1258. doi:10.1001/jamainternmed.2024.3819

Nursing home (NH) residents are at excess risks of atrial fibrillation (AF)–related stroke and oral anticoagulant (OAC)–related bleeding. In older adults (aged ≥65 years) with multimorbidity and AF, clinicians may select aspirin rather than OAC for stroke prophylaxis to limit bleeding risk. However, antiplatelets are unequivocally ineffective for preventing cardioembolic stroke in AF,1 while increasing bleeding risk.2 In another common scenario, patients with AF treated with OAC may also be prescribed an antiplatelet without indication. Studies reported prevalence of OAC use in long-stay NH residents with AF of 30% to 35%,3,4 but these claims-based studies were unable to capture aspirin use. In this study, we estimate the use of OAC and antiplatelets, including aspirin, among residents with AF.

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1 Comment for this article
Polytherapy may be counterproductive in Nursing home residents.
Rajeev Gupta, MBBS;MD;DM (Cardiology) | Spectrum Medical Center, and The Burjeel Royal Hospital, Al Ain, UAE
This article is timely raising awareness about the perils of unsubstantiated drug combinations. Somehow, such combinations and formulations are surprising, and not uncommon in real-world practice. Many times we have encountered iatrogenic diseases. It is imperative to be mindful of the disparate pharmacokinetics and pharmacodynamic properties of the most drugs commonly used. Combining an OAC with an antiplatelet agent alike aspirin/clopidogrel after 1 year of PCI is definitely counterproductive.
CONFLICT OF INTEREST: None Reported
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