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September 30, 2024
Viewpoint

Payer Coverage Considerations for Alzheimer Disease Blood-Based Biomarker Tests

Abstract Full Text
JAMA. Published online September 30, 2024. doi:10.1001/jama.2024.19084

This Viewpoint discusses proactively preparing to make informed payer coverage decisions to help address current disparities in Alzheimer disease diagnosis and treatment.

September 26, 2024
Original Investigation

Estimation of Tax Benefit of US Nonprofit Hospitals

Abstract Full Text
JAMA. Published online September 26, 2024. doi:10.1001/jama.2024.13413

This study uses data from Medicare Cost Reports to investigate the financial benefit US nonprofit hospitals receive from their tax-exempt status and outlines a standardized estimation methodology that can be replicated at the state and local levels.

September 23, 2024
Viewpoint

Climate Change and Health

Health Care Actions for Reducing Plastic Use and Pollution

Abstract Full Text
has multimedia
JAMA. Published online September 23, 2024. doi:10.1001/jama.2024.17961

This Viewpoint proposes a comprehensive sociotechnical approach spanning the entire plastics life cycle to reduce plastic use and pollution in health care.

September 20, 2024
Viewpoint

Integrating Clinical Trials and Practice

Diversity Action Plans in Clinical Trials

Abstract Full Text
JAMA. Published online September 20, 2024. doi:10.1001/jama.2024.16009

This Viewpoint discusses the US Food and Drug Administration’s upcoming mandate on diversity actions plans for trial sponsors and the importance of developing accountability mechanisms to monitor those plans.

Integrating Clinical Trials and Practice

The Promise and Perils of Diversity Action Plans for Clinical Trials

Abstract Full Text
JAMA. Published online September 20, 2024. doi:10.1001/jama.2024.18225

This Viewpoint discusses the US Food and Drug Administration’s authority to require drug and device sponsors to submit diversity action plans and policy gaps that limit the organization’s ability to achieve demographic representation in clinical trials.

September 19, 2024
Viewpoint

Discovery of cGAS as a DNA-Sensing Enzyme That Triggers Inflammation: 2024 Albert Lasker Basic Medical Research Award

Abstract Full Text
has audio
JAMA. Published online September 19, 2024. doi:10.1001/jama.2024.17873

In this Viewpoint, 2024 Albert Lasker Basic Medical Research Award winner Zhijian J. Chen describes his discovery of cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS), a DNA-sensing enzyme that triggers inflammation.

AIDS in Africa—Impact of Research: The 2024 Lasker-Bloomberg Public Service Award

Abstract Full Text
has audio
JAMA. Published online September 19, 2024. doi:10.1001/jama.2024.18271

In this Viewpoint, 2024 Lasker-Bloomberg Public Service Award winners Quarraisha Abdool Karim and Salim S. Abdool Karim discuss their journey in AIDS research in South Africa and the local and global health impact of this research.

Chemistry Matters—From a Putative Peptide to Effective Treatments for Diabetes and Obesity: 2024 Lasker-DeBakey Clinical Medical Research Award

Abstract Full Text
has audio
JAMA. Published online September 19, 2024. doi:10.1001/jama.2024.17571

In this Viewpoint, 2024 Lasker-DeBakey Clinical Medical Research Award winner Svetlana Mojsov describes her discovery of GLP-1 (7-37), the biologically active incretin that led to development of effective GLP-1 analogues for treating diabetes and obesity.

GLP-1 for Treating Obesity—Origin, History, and Evolution: 2024 Lasker-DeBakey Clinical Medical Research Award

Abstract Full Text
has audio
JAMA. Published online September 19, 2024. doi:10.1001/jama.2024.18000

In this Viewpoint, 2024 Lasker-DeBakey Clinical Medical Research Award winner Lotte Bjerre Knudsen describes her discovery of glucagon-like peptide-1 for the treatment of patients with obesity.

September 16, 2024
Original Investigation

Effect of High-Intensity vs Low-Intensity Noninvasive Positive Pressure Ventilation on the Need for Endotracheal Intubation in Patients With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease: The HAPPEN Randomized Clinical Trial

Abstract Full Text
JAMA. Published online September 16, 2024. doi:10.1001/jama.2024.15815

This randomized clinical trial compares the effect of high-intensity noninvasive positive pressure ventilation (NPPV) vs low-intensity NPPV on the need for endotracheal intubation in patients with an acute exacerbation of chronic obstructive pulmonary disease and hypercapnia.

Editorial

Noninvasive Ventilation in COPD—Pressure Matters

Abstract Full Text
JAMA. Published online September 16, 2024. doi:10.1001/jama.2024.0811
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