Brain Inflammation May Underlie Neuropsychiatric Symptoms of Dementia

Emily Harris

doi:10.1001/jama.2023.25768

Neuroinflammation鈥攁s measured by levels of activated microglia, the brain鈥檚 immune cells鈥攚as strongly linked with irritability, agitation, and nighttime disturbances in people with dementia, recent found. The results, published in 糖心vlog Open, were based on data from a cross-sectional study that involved 109 participants aged 38 to 87 years, about two-thirds of whom did not have cognitive impairment.

Higher levels of microglial activation, and particularly microglial activation鈥揳ssociated irritability, in participants with dementia were also tied to greater distress in their caregivers, family members, or close friends.

The findings indicate that microglial activation could function as a biomarker for neuropsychiatric symptoms in Alzheimer disease. Moreover, the association also suggests that drugs that target microglial activation have the potential to alleviate these symptoms in patients with Alzheimer disease.

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