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This study evaluates the role of CACNA1C variants in altered prefrontal neurons in cognitive disorders.

This randomized clinical trial evaluates the efficacy of home-use transcranial direct current stimulation, combined or not with a digital psychological intervention, vs sham for the treatment of major depression.

This cohort study uses mother-infant dyads to investigate whether alterations in newborn brain function precede the development of callous-unemotional traits and are associated with later symptom severity.

This cross-sectional study evaluates neural responses associated with risk of mania/hypomania and depression in 3 independent test samples.

This case-control study assesses the association of brain morphometric changes that deviate from the normative range and with positive symptoms, cognition, and conversion to a psychotic disorder among individuals at high risk for psychosis.

This case-control study models the processes that explain spatial patterns of gray matter volume loss in different stages of psychotic illness and assesses whether certain brain regions act as putative epicenters from which volume loss spreads.

This systematic review and meta-analysis examines data from studies of patients with first-episode psychosis to estimate the prevalence of clinically relevant neuroradiological abnormalities detected using magnetic resonance imaging.

This article discusses 2 possible mechanisms of action of electroconvulsive therapy.

This case-control study compares levels of serotonin type 4 receptor as well as verbal memory, working memory, reaction time, emotion recognition bias, and negative social emotions in unmedicated patients with major depressive disorder vs individuals without this diagnosis.

This article discusses why glutamate levels are abnormally elevated in the hippocampus of patients with schizophrenia and related disorders.

This study leverages a human data set of cannabis users and a rat model to evaluate the long-term outcomes of adolescent Δ⁹-tetrahydrocannabinol (THC) exposure on adult decision-making and impulse control.

This Viewpoint highlights how new insights into belief acquisition, storage, and change can transform our understanding of psychiatric disorders.

This cohort study examines whether blunted striatal activation to reward anticipation moderates the association between early behavioral inhibition and the developmental changes in depression and anxiety from adolescence to adulthood.

This cross-sectional study investigates changes in γ-aminobutyric acid, glutamate, and glutamine levels in a voxel in the left dorsolateral prefrontal cortex of participants with no, past, and current major depressive disorder using proton magnetic resonance spectroscopy.

This mendelian randomization study evaluates associations between brain structure and alcohol use.

This randomized clinical trial evaluates the safety and efficacy of at-home transcranial direct current stimulation in treating inattention in adults with attention-deficit/hyperactivity disorder.

This meta-analysis compares the efficacy and acceptability of different noninvasive brain stimulation interventions for treating negative symptoms.