Identification and Treatment of Neonatal Seizures During Therapeutic Hypothermia and Rewarming

Original Investigation

Association of Increased Seizures During Rewarming With Abnormal Neurodevelopmental Outcomes at 2-Year Follow-up

Lina F.聽Chalak,聽MD, MSCS; Athina聽Pappas,聽MD; Sylvia聽Tan,聽MS; Abhik聽Das,聽PhD; Pablo J.聽S谩nchez,聽MD; Abbot R.聽Laptook,聽MD; Krisa P.聽Van Meurs,聽MD; Seetha聽Shankaran,聽MD; Edward F.聽Bell,聽MD; Alexis S.聽Davis,聽MD, MSEpi; Roy J.聽Heyne,聽MD; Claudia聽Pedroza,聽PhD; Brenda B.聽Poindexter,聽MD, MS; Kurt聽Schibler,聽MD; Jon E.聽Tyson,聽MD, MPH; M. Bethany聽Ball,聽BS, CCRC; Rebecca聽Bara,聽RN, BSN; Cathy聽Grisby,聽BSN; Gregory M.聽Sokol,聽MD; Carl T.聽D鈥橝ngio,聽MD; Shannon E. G.聽Hamrick,聽MD; Kevin C.聽Dysart,聽MD; C. Michael聽Cotten,聽MD, MHS; William E.聽Truog,聽MD; Kristi L.聽Watterberg,聽MD; Christopher J.聽Timan,聽MD; Meena聽Garg,聽MD; Waldemar A.聽Carlo,聽MD; Rosemary D.聽Higgins,聽MD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network; Namasivayam 聽Ambalavanan; Monica V.聽Collins; Shirley S.聽Cosby; Myriam 聽Peralta-Carcelen; Vivien A.聽Phillips; David A.聽Randolph; Barbara 聽Alksninis; Robert T.聽Burke; Melinda 聽Caskey; Nicholas 聽Guerina; Angelita M.聽Hensman; Martin 聽Keszler; Mary Lenore 聽Keszler; Andrea M.聽Knoll; Emilee 聽Little; Elizabeth C.聽McGowan; William 聽Oh; Birju A.聽Shah; Ross 聽Sommers; Elisa 聽Vieira; Betty R.聽Vohr; Stephanie 聽Guilford; Satyan 聽Lakshminrusimha; Anne Marie 聽Reynolds; Michael G.聽Sacilowski; Ashley 聽Williams; Karen 聽Wynn; Anna Maria 聽Hibbs; Nancy S.聽Newman; Bonnie S.聽Siner; Eileen K.聽Stork; Michele C.聽Walsh; Arlene 聽Zadell; Michael S.聽Caplan; Richard A.聽Polin; Sally S.聽Adams; Luc P.聽Brion; Lijun 聽Chen; Alicia 聽Guzman; Elizabeth T.聽Heyne; Lizette E.聽Lee; Linda A.聽Madden; Emma 聽Ramon; Pablo J.聽S谩nchez; Catherine 聽Twell Boatman; Diana M.聽Vasil; Myra H.聽Wyckoff; Patricia L.聽Ashley; Joanne 聽Finkle; Kimberley A.聽Fisher; Ronald N.聽Goldberg; Ricki F.聽Goldstein; Sandra 聽Grimes; Kathryn E.聽Gustafson; William F.聽Malcolm; Ira 聽Adams-Chapman (deceased); Diane I.聽Bottcher; David P.聽Carlton; Sheena L.聽Carter; Ellen C.聽Hale; Yvonne C.聽Loggins; Colleen 聽Mackie; Ravi M.聽Patel; Barbara J.聽Stoll; Lynn 聽Wineski; Susan 聽Gunn; Heidi M.聽Harmon; Dianne E.聽Herron; Abbey C.聽Hines; Jeffery 聽Joyce; Carolyn 聽Lytle; Lucy C.聽Miller; Heike M.聽Minnich; Lu-Ann 聽Papile; Brenda B.聽Poindexter; Leslie 聽Richard; Lucy C.聽Smiley; Leslie Dawn聽Wilson; Michael J.聽Acarregui; Vipinchandra 聽Bhavsar; Jane E.聽Brumbaugh; Tarah T.聽Colaizy; John M.聽Dagle; Diane L.聽Eastman; Karen J.聽Johnson; Jonathan M.聽Klein; Julie B.聽Lindower; Steven J.聽McElroy; Cary R.聽Murphy; Glenda K.聽Rabe; Robert D.聽Roghair; Jeffrey L.聽Segar; Jacky R.聽Walker; John A.聽Widness; Dan L.聽Ellsbury; Cheri 聽Gauldin; Anne M.聽Holmes; Kathy 聽Johnson; Howard W.聽Kilbride; Eugenia K.聽Pallotto; Allison 聽Scott; Roopali 聽Bapat; Thomas 聽Bartman; Elizabeth 聽Bonachea; Helen 聽Carey; Michelle 聽Chao; Louis G.聽Chicoine; Bronte 聽Clifford; Marliese 聽Dion Nist; Erin 聽Fearns; Christine A.聽Fortney; Aubry 聽Fowler; Jennifer 聽Fuller; Jennifer L.聽Grothause; Ish 聽Gulati; Julie 聽Gutentag; Cole D.聽Hague; Krista 聽Haines; Brandon 聽Hart; Michael 聽Hokenson; Sudarshan R.聽Jadcherla; Marissa E.聽Jones; Sarah A.聽Keim; Patricia 聽Luzader; Nathalie L.聽Maitre; Sarah 聽McGregor; Pamela 聽Moorehead; Leif D.聽Nelin; Mary Ann 聽Nelin; Nehal A.聽Parikh; Elizabeth 聽Rodgers; Ruth 聽Seabrook; Tiffany 聽Sharp; Edward G.聽Shepherd; Jonathan L.聽Slaughter; Melanie 聽Stein; Rox Ann 聽Sullivan; Jodi A.聽Ulloa; Jon 聽Wispe; Tara 聽Wolfe; Keith O.聽Yeates; Lina 聽Yossef-Salameh; Nahla 聽Zaghoul; Stephanie 聽Wilson Archer; Soraya 聽Abbasi; Judy C.聽Bernbaum; Aasma S.聽Chaudhary; Dara M.聽Cucinotta; Sara B.聽DeMauro; Marsha 聽Gerdes; Hallam 聽Hurt; Haresh 聽Kirpalani; Toni 聽Mancini; Barbara 聽Schmidt; Kyle 聽Binion; Patrick 聽Conway; Osman 聽Farooq; Ronnie 聽Guillet; Cassandra A.聽Horihan; Rosemary L.聽Jensen; Nirupama 聽Laroira; Joan 聽Merzbach; Gary J.聽Myers; Premini 聽Sabaratnam; Ann Marie 聽Scorsone; Holly I.M.聽Wadkins; Kelley 聽Yost; Carla M.聽Bann; Margaret M.聽Crawford; Jenna 聽Gabrio; Marie G.聽Gantz; Scott A.聽McDonald; Jamie E.聽Newman; Jeanette 聽O鈥橠onnell Auman; Carolyn M.聽Petrie Huitema; James W.聽Pickett; Annie M.聽VonLehmden; Dennis 聽Wallace; Kristin M.聽Zaterka-Baxter; Valerie Y.聽Chock; Maria Elena 聽DeAnda; Anne M.聽DeBattista; Lynne C.聽Huffman; Casey E.聽Krueger; Ryan E.聽Lucash; Melinda S.聽Proud; David K.聽Stevenson; Heather L.聽Taylor; Hali E.聽Weiss; Teresa 聽Chanlaw; Uday 聽Devaskar; Rachel 聽Geller; Isabell B.聽Purdy; Sofia 聽Aliaga; Janice 聽Bernhardt; Carl L.聽Bose; Cynthia L.聽Clark; Matthew Maxwell聽Laughon; Diane D.聽Warner; Janice Kay聽Wereszczak; Conra 聽Backstrom Lacy; Andrea F.聽Duncan; Janell 聽Fuller; Carol H.聽Hartenberger; Jean R.聽Lowe; Robin K.聽Ohls; Sandra 聽Sundquist Beauman; John 聽Barks; Mary K.聽Christensen; Stephanie A.聽Wiggins; Monika 聽Bajaj; Sanjay 聽Chawla; Kirsten 聽Childs; Lilia C.聽De Jesus; Eunice 聽Hinz Woldt; Mary E.聽Johnson; Girija 聽Natarajan; Bogdan 聽Panaitescu; Jeannette E.聽Prentice; Beena G.聽Sood

JAMA Neurology
Comment & Response

Identification and Treatment of Neonatal Seizures During Therapeutic Hypothermia and Rewarming鈥擱eply

Lina F.聽Chalak,聽MD, MSCS

JAMA Neurology

To the Editor We read with interest the article by Chalak et al¹ on the association of increased seizures during rewarming with abnormal neurodevelopmental outcomes at 2-year follow-up. The authors observed adverse neurodevelopmental outcomes among infants with seizures during rewarming after completing therapeutic hypothermia for hypoxic ischemic encephalopathy. Compared with infants without seizures during rewarming, infants with these seizures were more likely to have abnormal background amplitude integrated electroencephalography (aEEG) and an incidence of basal ganglia-thalamic injury that was 2-fold higher than that of white matter injury. This study highlights the need to optimize seizure identification, quantification, and treatment.

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