Total skin electron beam therapy (TSEBT) is a commonly used modality in the management of cutaneous T-cell lymphoma. Much information is available regarding the indications and results of such therapy,^1,2 but there is little information that specifically delineates the treatment process and the short- and long-term sequelae. This article reviews the specifics of treatment delivery (Stanford technique^3,4) as performed at Yale University (New Haven, Conn) as well as the expected sequelae during and following the treatment course.

Total skin electron beam therapy is a technically challenging treatment and although many radiation oncology centers are equipped and capable of delivering such therapy, it is typically only provided by centers with significant experience in the treatment of cutaneous T-cell lymphoma. In the United States and Europe, there continue to be misconceptions in the dermatology community regarding the actual TSEBT treatment and its side effects. This is understandable since the treatment is provided on a regular basis at only a relatively small number of centers. The following serves as a reference for dermatologists and briefly reviews the mechanics of treatment delivery and expected clinical effects related to TSEBT.