Total skin electron beam therapy (TSEBT) is a commonly used modality in the management of cutaneous T-cell lymphoma. Much information is available regarding the indications and results of such therapy,1,2 but there is little information that specifically delineates the treatment process and the short- and long-term sequelae. This article reviews the specifics of treatment delivery (Stanford technique3,4) as performed at Yale University (New Haven, Conn) as well as the expected sequelae during and following the treatment course.