Among the early methods of treatment of enlargement of the thyroid gland is that of injection of tincture of iodin directly into the gland substance. This form of treatment grew out of the use of iodin painted over the gland area and its internal administration in cases of goiter. According to Prinz,¹ Sköldberg first proposed the method in 1855. The first reports available, however, are those of Luton,² 1867, and Bertin,³ 1868. The intraglandular injection of the tincture was proposed and used first in those cases which did not show decrease in size of the enlarged gland with other forms of iodin treatment. The case reports show that those which were most benefited were simple and cystic goiters in young persons. Luecke,⁴ 1868, introduced the treatment in Germany. His report shows also that of the cases so treated, those showing improvement were cases of simple and