EARLY ATTEMPTS AT BRADY INSTITUTE TO PRODUCE AN INTRAVENOUS GERMICIDEÌý During the last eight years the research work in the laboratory of the Brady Urological Institute has been largely concerned with the development of germicides and antiseptics. Starting with an effort to make a compound of phenolsulphonephthalein which, when injected intravenously, would act as a genito-urinary germicide, investigation was broadened to an exhaustive study of many dyestuffs and compounds from them. In this work, E. C. White, E. G. Davis and E. O. Swartz cooperated with us in chemical and bacteriologic experimental and clinical studies, many of which have been published. Impressed with the possibilities of using dyes as a basis for the development of therapeutic compounds, we have concentrated our efforts on the production of new drugs possessing the penetrating qualities of dyes which are, at the same time, germicidal and relatively nontoxic and nonirritating, so that they can