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Comment & Response
December 5, 2018

Addressing Clinical Significance

Author Affiliations
  • 1The Johns Hopkins University School of Medicine, Baltimore, Maryland
  • 2The Armstrong Institute for Patient Safety and Quality, Johns Hopkins Medicine, Baltimore, Maryland
  • 3Division of Acute Care Surgery, Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland
  • 4Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland
  • 5Department of Emergency Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland
  • 6Department of Health Policy and Management, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
JAMA Surg. 2019;154(2):188-189. doi:10.1001/jamasurg.2018.4748

To the Editor Health care researchers have the difficulty of balancing statistical and clinical significance when publishing research findings. Throughout the JAMA Surgery Practical Guide to Surgical Data Sets series,1 many articles conveyed the concern that large data set analyses can produce statistically but not clinically significant results. This possibility requires the researcher and reader to make a judgement on the value of the information discovered in the study. However, it seems that authors more frequently take a clinician or cost perspective rather than consider the patient experience.

In the JAMA Surgery series, one article2 included a statistically significant outcome that improved patient length of stay by 0.1 days, approximately 2.4 hours, but was deemed 鈥減ractically meaningless.鈥 We disagree with this rationale. As one of the driving profits in a hospital, the operating room generates an average of $36 to $37 per minute.3 When the operating room is delayed because of no available beds in the recovery room because patients are not being transitioned to the floor because patients are not being discharged, a 2.4-hour delay in discharge can cause major logjams in patient flow and resultant increased costs. For a typical, busy hospital running near maximum capacity, this loss may be staggering.

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