The current referenced double-blind randomized clinical trial by Lopez and others1 compared strategies of intraoperative hyperoxia vs normoxia during elective cardiac surgery to assess the impact on oxidative stress and clinical markers of end-organ damage including acute kidney injury (AKI). The primary end points of the study were changes in the levels of F2-isoprostanes and isofurans as markers of oxidative stress and serum creatinine from baseline to postoperative day 2. The authors conclude that intraoperative management with hyperoxia did not affect clinical outcomes in the postoperative period despite a significant increase in intraoperative serum oxidative stress markers.