Daniel C. Javitt, MD, PhD; Cameron S. Carter, MD; John H. Krystal, MD; et al.
free access
JAMA Psychiatry. 2018;75(1):11-19. doi:10.1001/jamapsychiatry.2017.3572
This randomized clinical trial aims to identify measures with sufficient effect size and cross-site reliability to serve as glutamatergic target engagement biomarkers within early-phase clinical studies.
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Invited Commentary
Paving the Way for Targeted Drug Development in Schizophrenia
Nina Vanessa Kraguljac, MD; Adrienne Carol Lahti, MD
JAMA Psychiatry
Torsten Santavirta, PhD; Nina Santavirta, PhD; Stephen E. Gilman, ScD
open access
JAMA Psychiatry. 2018;75(1):21-27. doi:10.1001/jamapsychiatry.2017.3511
This multigeneration, population-based cohort study compares the risk of psychiatric hospitalization among cousins whose parents were vs were not exposed to the Finnish evacuation policy that involved a mean 2-year stay with a Swedish foster family.
Judith Allardyce, MRCPsych, PhD; Ganna Leonenko, PhD; Marian Hamshere, PhD; et al.
open access
JAMA Psychiatry. 2018;75(1):28-35. doi:10.1001/jamapsychiatry.2017.3485
This case-control study examines the association between polygenic liability for schizophrenia and psychotic presentations of bipolar disorder.
Hannah E. Jongsma, MPH; Charlotte Gayer-Anderson, PhD; Antonio Lasalvia, MD, PhD; et al.
open access
JAMA Psychiatry. 2018;75(1):36-46. doi:10.1001/jamapsychiatry.2017.3554
This international multisite incidence study estimates the incidence of psychotic disorders across 17 catchment areas in 6 countries and examines the variance between catchment areas by putative environmental risk factors.
Ana Pérez-Vigil, MD; Lorena Fernández de la Cruz, PhD; Gustaf Brander, MSc; et al.
free access
has audio
JAMA Psychiatry. 2018;75(1):47-55. doi:10.1001/jamapsychiatry.2017.3523
This population-based study of the Swedish National Patient Register investigates the association of obsessive-compulsive disorder with educational outcomes, adjusting for covariates and factors shared between siblings.
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Podcast:
Evaluating the Association of Obsessive-Compulsive Disorder With Objective Indicators of Educational Attainment
Bruce L. Rollman, MD, MPH; Bea Herbeck Belnap, Dr Biol Hum; Kaleab Z. Abebe, PhD; et al.
open access
JAMA Psychiatry. 2018;75(1):56-64. doi:10.1001/jamapsychiatry.2017.3379
This randomized clinical trial examines the effectiveness of combining an internet support group with an online computerized cognitive behavioral therapy provided via a collaborative care program for treating depression and anxiety vs computerized cognitive behavioral therapy alone, and whether providing computerized cognitive behavioral therapy in this manner is more effective than primary care physicians鈥� usual care.
International Consortium on Lithium Genetics (ConLi+Gen)
free access
JAMA Psychiatry. 2018;75(1):65-74. doi:10.1001/jamapsychiatry.2017.3433
This genome-wide association study tests whether a polygenic score for schizophrenia is associated with treatment response to lithium in bipolar affective disorder and explores the potential molecular underpinnings of this association.
Lucy Richardson, MSc; Yasir Hameed, MRCPsych; Jesus Perez, PhD, MRCPsych; et al.
open access
JAMA Psychiatry. 2018;75(1):75-83. doi:10.1001/jamapsychiatry.2017.3582
This cohort study investigated neighborhood-level factors associated with first-episode psychosis in a predominantly rural population in the East of England.
Willemijn J. Jansen, PhD; Rik Ossenkoppele, PhD; Betty M. Tijms, PhD; et al.
free access
JAMA Psychiatry. 2018;75(1):84-95. doi:10.1001/jamapsychiatry.2017.3391
This cross-sectional, multicenter amyloid biomarker study investigates whether amyloid-尾 aggregation is associated with cognitive functioning in persons without dementia.