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October 2024 - July 1959

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Issue

July 2015, Vol 72, No. 7, Pages 629-736

In This Issue of JAMA Psychiatry

Highlights

Abstract Full Text
free access
JAMA Psychiatry. 2015;72(7):629. doi:10.1001/jamapsychiatry.2014.1894
Viewpoint

Pragmatism Instead of Mechanism: A Call for Impactful Biological Psychiatry

Abstract Full Text
JAMA Psychiatry. 2015;72(7):631-632. doi:10.1001/jamapsychiatry.2015.0497

This Viewpoint discusses developing a risk-prediction framework in psychiatric practice.

Biomarkers With a Mechanistic Focus

Abstract Full Text
JAMA Psychiatry. 2015;72(7):633-634. doi:10.1001/jamapsychiatry.2015.0498
Original Investigation

Polygenic Risk Score, Parental Socioeconomic Status, Family History of Psychiatric Disorders, and the Risk for Schizophrenia: A Danish Population-Based Study and Meta-analysis

Abstract Full Text
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JAMA Psychiatry. 2015;72(7):635-641. doi:10.1001/jamapsychiatry.2015.0346

This case-control study reports that schizophrenia is associated with the polygenic risk score, family psychiatric history, and socioeconomic status.

Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder

Abstract Full Text
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JAMA Psychiatry. 2015;72(7):642-650. doi:10.1001/jamapsychiatry.2015.0554

This genome-wide association analysis identifies a novel locus for neuroticism and shows polygenic association with major depressive disorder (MDD).

Genetic and Environmental Influences on the Developmental Course of Attention-Deficit/Hyperactivity Disorder Symptoms From Childhood to Adolescence

Abstract Full Text
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JAMA Psychiatry. 2015;72(7):651-658. doi:10.1001/jamapsychiatry.2015.0469

This prospective study examines the effects of genes and environment on the developmental course of attention-deficit/hyperactivity disorder (ADHD) symptoms from childhood to adolescence.

d-Cycloserine vs Placebo as Adjunct to Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder and Interaction With Antidepressants: A Randomized Clinical Trial

Abstract Full Text
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JAMA Psychiatry. 2015;72(7):659-667. doi:10.1001/jamapsychiatry.2015.0546

This randomized clinical trial examines whether d-cycloserine augments cognitive behavioral therapy in the treatment of obsessive-compulsive disorder (OCD) and whether concomitant use of antidepressants moderates the effects of d-cycloserine.

White Matter Differences Among Adolescents Reporting Psychotic Experiences: A Population-Based Diffusion Magnetic Resonance Imaging Study

Abstract Full Text
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JAMA Psychiatry. 2015;72(7):668-677. doi:10.1001/jamapsychiatry.2015.0137

This population-based, case-control study investigates white matter differences using diffusion-weighted imaging (whole-brain tractography) in adolescents who report psychotic experiences.

Two Patterns of White Matter Abnormalities in Medication-Naive Patients With First-Episode Schizophrenia Revealed by Diffusion Tensor Imaging and Cluster Analysis

Abstract Full Text
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JAMA Psychiatry. 2015;72(7):678-686. doi:10.1001/jamapsychiatry.2015.0505

This cross-sectional diffusion tensor imaging study found 2 distinct patterns of white matter abnormalities exist at the early phase of schizophrenia, with those having global abnormalities experiencing more severe negative symptoms.

State-Dependent Differences in Emotion Regulation Between Unmedicated Bipolar Disorder and Major Depressive Disorder

Abstract Full Text
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JAMA Psychiatry. 2015;72(7):687-696. doi:10.1001/jamapsychiatry.2015.0161

This cross-sectional study reports that medication-free patients with major depressive disorder vs bipolar disorder appear to differ in brain activations during emotion regulation, both while depressed and in remission.

Psychotic Experiences in the General Population: A Cross-National Analysis Based on 31 261 Respondents From 18 Countries

Abstract Full Text
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JAMA Psychiatry. 2015;72(7):697-705. doi:10.1001/jamapsychiatry.2015.0575

This population epidemiology study uses WHO survey data to provide a comprehensive description of psychotic experiences among adults and serves as a foundation for further research about these rare variegated episodes.

Transdiagnostic Factors and Mediation of the Relationship Between Perceived Racial Discrimination and Mental Disorders

Abstract Full Text
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JAMA Psychiatry. 2015;72(7):706-713. doi:10.1001/jamapsychiatry.2015.0148

To examine the direct and indirect relationships between perceived racial discrimination and common forms of psychopathology, 12 common diagnoses were assessed in a nationally representative sample of African American and Afro-Caribbean adults.

Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial

Abstract Full Text
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JAMA Psychiatry. 2015;72(7):714-726. doi:10.1001/jamapsychiatry.2015.0111

This randomized clinical trial notes recurrence of depressive symptoms in perimenopausal women during estradiol withdrawal. See also the editorial by Newhouse and Albert.

Neuroscience and Psychiatry

Estrogen, Stress, and Depression: A Neurocognitive Model

Abstract Full Text
JAMA Psychiatry. 2015;72(7):727-729. doi:10.1001/jamapsychiatry.2015.0487

This Neuroscience and Psychiatry article proposes that changing levels of estradiol may directly modify the activity of dorsal and ventral emotional regulation nodes and circuits, modifying the cognitive and emotional consequences of life stress and leading to depression in women.

Research Letter

Absence of N-Methyl-D-Aspartate Receptor IgG Autoantibodies in Schizophrenia: The Importance of Cross-Validation Studies

Abstract Full Text
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JAMA Psychiatry. 2015;72(7):731-733. doi:10.1001/jamapsychiatry.2015.0526

This research letter investigates the presence of anti-GluN1 IgG autoantibodies in 475 patients with a schizophrenia spectrum disorder and includes the cross-validation of positive samples.

Comment & Response

Benzodiazepines in Anxiety Disorders

Abstract Full Text
JAMA Psychiatry. 2015;72(7):733-734. doi:10.1001/jamapsychiatry.2015.0182

Restricting Benzodiazepines to Short-Term Prescription

Abstract Full Text
JAMA Psychiatry. 2015;72(7):734-735. doi:10.1001/jamapsychiatry.2015.0351

A More Robust Test of the Penrose Hypothesis

Abstract Full Text
JAMA Psychiatry. 2015;72(7):735-736. doi:10.1001/jamapsychiatry.2015.0212

Testing the Penrose Hypothesis—Reply

Abstract Full Text
JAMA Psychiatry. 2015;72(7):736. doi:10.1001/jamapsychiatry.2015.0217
Correction

Error in Figure Caption

Abstract Full Text
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JAMA Psychiatry. 2015;72(7):736. doi:10.1001/jamapsychiatry.2015.0937

Incorrect Sentences in Abstract

Abstract Full Text
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JAMA Psychiatry. 2015;72(7):736. doi:10.1001/jamapsychiatry.2015.0982
JAMA Psychiatry Masthead

JAMA Psychiatry

Abstract Full Text
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JAMA Psychiatry. 2015;72(7):630. doi:10.1001/jamapsychiatry.2014.1895
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