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June 2015, Vol 72, No. 6, Pages 525-625

In This Issue of JAMA Psychiatry

Highlights

Abstract Full Text
free access
JAMA Psychiatry. 2015;72(6):525. doi:10.1001/jamapsychiatry.2014.1888
Viewpoint

Are Anti-inflammatory Therapies Viable Treatments for Psychiatric Disorders?Where the Rubber Meets the Road

Abstract Full Text
JAMA Psychiatry. 2015;72(6):527-528. doi:10.1001/jamapsychiatry.2015.22

This Viewpoint reports on the accumulating data indicating that inflammation may play a role in a host of psychiatric illnesses.

The Impact of Air Pollutants on the Brain

Abstract Full Text
JAMA Psychiatry. 2015;72(6):529-530. doi:10.1001/jamapsychiatry.2015.0192

This Viewpoint discusses the effect of air pollutants on the brain and the benefits of environmental regulations and compliance and enforcement actions.

Original Investigation

Effects of Prenatal Exposure to Air Pollutants (Polycyclic Aromatic Hydrocarbons) on the Development of Brain White Matter, Cognition, and Behavior in Later Childhood

Abstract Full Text
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JAMA Psychiatry. 2015;72(6):531-540. doi:10.1001/jamapsychiatry.2015.57

This cross-sectional imaging study identifies the effects of prenatal polycyclic aromatic hydrocarbon exposure on brain structure and assesses the cognitive and behavioral correlates of those abnormalities in school-age children.

Circuit- and Diagnosis-Specific DNA Methylation Changes at γ-Aminobutyric Acid–Related Genes in Postmortem Human Hippocampus in Schizophrenia and Bipolar Disorder

Abstract Full Text
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JAMA Psychiatry. 2015;72(6):541-551. doi:10.1001/jamapsychiatry.2015.49

This epigenetic association study investigates whether aberrant DNA methylation contributes to circuit- and diagnosis-specific abnormal expression of GAD1 regulatory network genes in schizophrenia and bipolar disorder.

Abnormalities in Hemispheric Specialization of Caudate Nucleus Connectivity in Schizophrenia

Abstract Full Text
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JAMA Psychiatry. 2015;72(6):552-560. doi:10.1001/jamapsychiatry.2014.3176

This study suggests that hemispheric specialization could serve as a potential imaging biomarker of schizophrenia.

Risk of Suicide Among US Military Service Members Following Operation Enduring Freedom or Operation Iraqi Freedom Deployment and Separation From the US Military

Abstract Full Text
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JAMA Psychiatry. 2015;72(6):561-569. doi:10.1001/jamapsychiatry.2014.3195

This retrospective cohort design uses administrative data to examine the association between deployment and suicide among all 3.9 million US military personnel who served during Operation Enduring Freedom or Operation Iraqi Freedom, including suicides that occurred after separation.

Risk of Suicide Following Deliberate Self-poisoning

Abstract Full Text
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JAMA Psychiatry. 2015;72(6):570-575. doi:10.1001/jamapsychiatry.2014.3188

This population-based cohort study finds that a first self-poisoning episode is a strong predictor of subsequent suicide and premature death.

Urban vs Rural Residence and the Prevalence of Depression and Mood Disorder Among African American Women and Non-Hispanic White Women

Abstract Full Text
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JAMA Psychiatry. 2015;72(6):576-583. doi:10.1001/jamapsychiatry.2015.10

National Survey of American Life data were used to examine the interaction of urbanicity and race/ethnicity on lifetime and 12-month major depressive disorder and mood disorder prevalence for African American women and non-Hispanic white women.

Impaired Functional Connectivity Within and Between Frontostriatal Circuits and Its Association With Compulsive Drug Use and Trait Impulsivity in Cocaine Addiction

Abstract Full Text
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JAMA Psychiatry. 2015;72(6):584-592. doi:10.1001/jamapsychiatry.2015.1

This case-control study finds that cocaine addiction is associated with disturbed resting-state functional connectivity in several specific striatal-cortical circuits.

Extended-Release Mixed Amphetamine Salts vs Placebo for Comorbid Adult Attention-Deficit/Hyperactivity Disorder and Cocaine Use Disorder: A Randomized Clinical Trial

Abstract Full Text
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JAMA Psychiatry. 2015;72(6):593-602. doi:10.1001/jamapsychiatry.2015.41

This randomized clinical trial in patients with comorbid adult attention-deficit/hyperactivity disorder (ADHD) and cocaine use disorder examined whether extended-release mixed amphetamine salts are effective for both improving symptoms of ADHD and reducing cocaine use.

Meta-analysis

Large-Scale Network Dysfunction in Major Depressive Disorder: A Meta-analysis of Resting-State Functional Connectivity

Abstract Full Text
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JAMA Psychiatry. 2015;72(6):603-611. doi:10.1001/jamapsychiatry.2015.0071

The findings of this database study provide an empirical foundation for a neurocognitive model in which network dysfunction underlies core cognitive and affective abnormalities in depression.

Effect of Depression and Diabetes Mellitus on the Risk for Dementia: A National Population-Based Cohort Study

Abstract Full Text
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JAMA Psychiatry. 2015;72(6):612-619. doi:10.1001/jamapsychiatry.2015.0082

This population-based cohort study reports an independent association of depression and diabetes mellitus (DM) with the risk for dementia in a national population sample from medical registries. See also the Invited Commentary by Reynolds.

Invited Commentary

Promoting Healthy Brain Aging

Abstract Full Text
JAMA Psychiatry. 2015;72(6):619-620. doi:10.1001/jamapsychiatry.2015.0174
Editor's Note

Wayne Katon, MD

Abstract Full Text
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JAMA Psychiatry. 2015;72(6):621. doi:10.1001/jamapsychiatry.2015.0634
Research Letter

Speed of Psychosis Progression in People at Ultra-High Clinical Risk: A Complementary Meta-analysis

Abstract Full Text
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JAMA Psychiatry. 2015;72(6):622-623. doi:10.1001/jamapsychiatry.2015.0094

This meta-analysis discusses the speed of psychosis progression in patients at ultra-high risk.

Comment & Response

The Popularity of Benzodiazepines, Their Advantages, and Inadequate Pharmacological Alternatives

Abstract Full Text
JAMA Psychiatry. 2015;72(6):623-624. doi:10.1001/jamapsychiatry.2014.3248

Suicide Risk: Sunshine or Temperature Increase?

Abstract Full Text
JAMA Psychiatry. 2015;72(6):624-625. doi:10.1001/jamapsychiatry.2014.3223

The Popularity of Benzodiazepines, Their Advantages, and Inadequate Pharmacological Alternatives—Reply

Abstract Full Text
JAMA Psychiatry. 2015;72(6):624. doi:10.1001/jamapsychiatry.2015.24

Medusa's Head and Ancient Aristotelian Biology

Abstract Full Text
JAMA Psychiatry. 2015;72(6):625. doi:10.1001/jamapsychiatry.2014.3225
Correction

Missing Byline Author

Abstract Full Text
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JAMA Psychiatry. 2015;72(6):625. doi:10.1001/jamapsychiatry.2015.0764
JAMA Psychiatry Masthead

JAMA Psychiatry

Abstract Full Text
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JAMA Psychiatry. 2015;72(6):526. doi:10.1001/jamapsychiatry.2014.1889
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