ÌÇÐÄvlog

Aberg et al sought to identify the specific genetic variants and pathways that increase susceptibility to schizophrenia in an effort to improve understanding of the molecular and biological mechanisms involved with the disease. See also the editorial by Hardy.

Timms et al identify new genetic factors strongly predisposing to schizophrenia in families with multiple affected individuals with schizophrenia.

Kandaswamy et al examined genetic markers at the gene encoding the metabotropic glutamate receptor 3 to evaluate the allelic association with bipolar disorder.

Kendler et al determine the structure of genetic and environmental risk factors for the 9 DSM-IV symptomatic MD criteria.

Milad and colleagues conducted a cross-sectional, case-control, functional magnetic resonance imaging study examining the psychophysiological and neurobiological correlates of conditioned fear extinction in patients with obsessive-compulsive disorder (OCD).

Beucke et al determined regions of abnormal degree connectivity in 46 patients with obsessive-compulsive disorder (OCD) to investigate whether connectivity measures are affected by antidepressant medication in this population.

To evaluate the efficacy of vigabatrin to treat cocaine dependence, Somoza et al performed a 12-week trial among 186 treatment seekers, with follow-up visits at weeks 13, 16, 20, and 24. Participants received vigabatrin (3.0 g/d) or matched placebo, plus cognitive behavioral therapy and individual counseling for 13 weeks. See Editorial by Silverman.

Decety et al evaluated the differences in patterns of neural activity in 80 incarcerated individuals with psychopathy and incarcerated persons serving as controls during the perception of empathy-eliciting stimuli depicting other people experiencing pain.