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Gogtay and coauthors evaluated white matter growth differences in 49 healthy siblings of patients with childhood-onset schizophrenia (COS) in a 5-year longitudinal study.

Wassink and coworkers performed a case-control analysis of covariance in a volunteer sample of 335 individuals with schizophrenia spectrum disorders and 198 healthy volunteers to evaluate associations of the SNP rs1344706 with brain structure and the core symptoms of schizophrenia.

Holt and colleagues conducted a cross-sectional case control, functional magnetic resonance imaging study to measure autonomic and neural responses during the acquisition and extinction of conditioned fear and the delayed recall of fear and extinction memories in schizophrenic patients and healthy control participants.

In a pharmacogenetic association study, Malhotra and coauthors identify single-nucleotide polymorphisms associated with antipsychotic drug–induced weight gain.

Using 2 inception cohorts of depressed and healthy participants, Siegle and coauthors examined whether subgenual anterior cingulate cortex (sgACC) activity serves as a prognostic outcome marker of cognitive therapy for depression and whether sgACC activity changes in treatment.

Tromp et al investigated structural connectivity between ventral prefrontal cortex or anterior cingulate cortex areas and the amygdala in GAD and assessed associations with functional connectivity between those areas. Fractional anisotropy values in the uncinate fasciculus were measured by tract-based analysis for diffusion-tensor imaging data.

Using national epidemiologic data from adolescent, college, and household-residing women, Walsh et al estimate the prevalence of sexual revictimization and posttraumatic stress disorder in 3 different populations.

In a cross-sectional survey, Merikangas et al present the prevalence and clinical correlates of mania with and without depressive episodes in a representative sample of US adolescents.

To contrast changes in brain activation related to symptomatic improvement with use of the stimulant methylphenidate vs the nonstimulant atomoxetine, Schulz and coauthors recruited 36 youth with attention-deficit/hyperactivity disorder who underwent functional magnetic resonance imaging from randomized clinical trials.

Gregory and colleagues conducted a cross-sectional case-control structural magnetic resonance imaging study of 66 men to identify structural gray matter differences between persistent violent offenders who meet criteria for antisocial personality disorder and the syndrome of psychopathy and those meeting criteria only for ASPD.

Naltrexone is approved for treatment of opioid addition in Russia. Krupitsky et al compared rates of relapse among 3 groups of opioid-addicted patients receiving oral naltrexone, implanted naltrexone, or placebo.