Arnt F. A. Schellekens, MD; Barbara Franke; Bart Ellenbroek, PhD; et al.
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Arch Gen Psychiatry. 2012;69(4):339-348. doi:10.1001/archgenpsychiatry.2011.1335
Schellekens and coauthors conducted a case-control pharmacogenetic challenge study to test central dopamine receptor sensitivity as an intermediate phenotype for alcohol dependence.
Hilleke E. Hulshoff Pol, PhD; G. Caroline M. van Baal, PhD; Hugo G. Schnack, PhD; et al.
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Arch Gen Psychiatry. 2012;69(4):349-359. doi:10.1001/archgenpsychiatry.2011.1615
Whether patients with schizophrenia and patients with bipolar disorder display overlapping abnormalities in brain volumes and cortical thickness and whether these are caused by shared genetic or environmental influences were investigated by Hulshoff Pol et al.
Robin L. Aupperle, PhD; Carolyn B. Allard, PhD; Erin M. Grimes, PsyD; et al.
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Arch Gen Psychiatry. 2012;69(4):360-371. doi:10.1001/archgenpsychiatry.2011.1539
Aupperle and coauthors conducted a case-control, cross-sectional study to determine whether posttraumatic stress disorder (PTSD) relates to greater disruption in prefrontal-subcortical networks during emotional anticipation.
Ronald C. Kessler, PhD; Shelli Avenevoli, PhD; E. Jane Costello, PhD; et al.
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Arch Gen Psychiatry. 2012;69(4):372-380. doi:10.1001/archgenpsychiatry.2011.160
Kessler et al present estimates of 12-month and 30-day prevalence, persistence (12-month prevalence among lifetime cases and 30-day prevalence among 12-month cases), and sociodemographic correlates of commonly occurring DSM-IV disorders among adolescents in the National Comorbidity Survey Replication Adolescent Supplement (NCS-A).
Ronald C. Kessler, PhD; Shelli Avenevoli, PhD; Jane Costello, PhD; et al.
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Arch Gen Psychiatry. 2012;69(4):381-389. doi:10.1001/archgenpsychiatry.2011.1603
Kessler et al present national data on the 12-month prevalence and sociodemographic correlates of serious emotional disturbances.
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Podcast:
Severity of 12-Month DSM-IV Disorders in the National Comorbidity Survey Replication Adolescent Supplement
Joel Swendsen, PhD; Marcy Burstein, PhD; Brady Case, MD; et al.
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Arch Gen Psychiatry. 2012;69(4):390-398. doi:10.1001/archgenpsychiatry.2011.1503
Swendsen et al examine the prevalence, age at onset, and sociodemographic correlates of alcohol and illicit drug use and abuse among US adolescents.
Christina R. Di Iorio, EdM; Tristan J. Watkins, BA; Mary S. Dietrich, PhD; et al.
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Arch Gen Psychiatry. 2012;69(4):399-409. doi:10.1001/archgenpsychiatry.2011.156
In a cross-sectional case-control study comparing serotonin2A receptor levels in abstinent female MDMA (3,4-methylenedioxymethamphetamine) polydrug users with those in women who did not use MDMA, Di Iorio and coauthors determine whether MDMA use is associated with chronic reductions in serotonin signaling in the cerebral cortex of women as reflected by increased serotonin2A receptor levels.
Wayne Katon, MD; Courtney R. Lyles, PhD; Melissa M. Parker, MS; et al.
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Arch Gen Psychiatry. 2012;69(4):410-417. doi:10.1001/archgenpsychiatry.2011.154
Katon et al determine whether comorbid depression in patients with type 2 diabetes increases the risk of development of dementia.
Kelly P. Cosgrove, PhD; Irina Esterlis, PhD; Sherry A. McKee, PhD; et al.
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Arch Gen Psychiatry. 2012;69(4):418-427. doi:10.1001/archgenpsychiatry.2011.1465
The availability of nicotinic acetylcholine receptors containing the β2 subunit (β2*-nAChRs) in male and female smokers vs nonsmokers was studied by Cosgrove et al and the associations among nicotinic acetylcholine receptors containing the β2 subunit availability, tobacco smoking characteristics, and female sex steroid hormone levels was determined.
Trine Munk-Olsen, PhD; Thomas Munk Laursen, PhD; Samantha Meltzer-Brody, MD, MPH; et al.
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Arch Gen Psychiatry. 2012;69(4):428-434. doi:10.1001/archgenpsychiatry.2011.157
Using a population-based cohort, Munk-Olsen et al study to what extent psychiatric disorders with postpartum onset are early manifestations of an underlying bipolar affective disorder.