The US Preventive Services Task Force (USPSTF) updated their recommendations¹ and evidence report and systematic review² regarding screening for unhealthy drug use. They now recommend clinicians screen all populations of adults, including pregnant women, in primary care settings for unhealthy drug use who do not currently have a substance use disorder (SUD) diagnosis or receive addiction treatment.² The recommendation, with a grade B (screening should be implemented when services for accurate diagnosis, effective treatment, and appropriate care can be offered or referred), is an update to its 2008 inconclusive guidance on the relative benefits and harms for adults. However, the USPSTF maintained its inconclusive recommendation for adolescents given a lack of high-quality evidence (I statement).