Recently completed genetic studies,1,2 the largest and most comprehensive of their kind, help resolve schizophrenia鈥檚 complex pathobiology. With a preponderance of implicated genes localizing to hippocampal glutamatergic neurons, in particular pathogenic loss-of-function mutations in subunits of 伪-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-d-aspartate (NMDA) glutamate receptors, the genetics inform the disorder鈥檚 anatomy and its pathophysiology.